Effects of Photobiomodulation on Degranulation and Number of Mast Cells and Wound Strength in Skin Wound Healing of Streptozotocin-Induced Diabetic Rats

Bagheri, Mohammad; Amini, Abdollah; Abdollahifar, Mohammad‐Amin; Ghoreishi, Seyed Kamran; Piryaei, Abbas; Pouriran, Ramin; Chien, Sufan; Dadras, Sara; Rezaei, Fatemehalsadat; Bayat, Mohammad

doi:10.1089/pho.2018.4453

Cited by 37 publications

(15 citation statements)

References 37 publications

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“…It is possible that circulating immune cells (mast cells, macrophages, etc. ), stimulated by PBM, [81][82][83][84] could transduce protective signals from distal tissues to sites of injury such as the brain, heart, or gut.…”

Section: Photobiomodulationmentioning

confidence: 99%

“Photobiomics”: Can Light, Including Photobiomodulation, Alter the Microbiome?

Liebert

Bicknell

Johnstone

et al. 2019

Photobiomodulation, Photomedicine, and Laser Surgery

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Section: Photobiomodulationmentioning

confidence: 99%

“Photobiomics”: Can Light, Including Photobiomodulation, Alter the Microbiome?

Liebert

Bicknell

Johnstone

et al. 2019

Photobiomodulation, Photomedicine, and Laser Surgery

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“…Studies on MSCs in tissue engineering have been gaining prominence in recent decades, especially in the reconstruction of dermal tissues due to the high capacity for self‐renewal, proliferation, and differentiation in several types of cells, such as epithelial cells (Caliari‐Oliveira et al, 2016). Thus, in an attempt to accelerate healing processes, ensuring a good tissue quality, studies have explored the association of PBM with MSCs in an attempt to create a low‐cost alternative, easy application as a treatment for cutaneous wounds (Amini et al, 2018; Bagheri et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Effect of photobiomodulation associated with cell therapy in the process of cutaneous regeneration in third degree burns in rats

Andrade

Brassolatti

Luna

et al. 2020

J Tissue Eng Regen Med

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Due to the complexity involved in the healing process of full thickness burns, the literature looks for alternatives to optimize tissue reconstruction. The objective of this study was to explore the action of photobiomodulation therapy associated with MSCs in the healing process of third degree burns. A total of 96 male Wistar rats were used, distributed in four groups with 24 animals each: Control Group, Laser Group, Cell Therapy Group, and Laser Group and Cell Therapy. The burn was performed with aluminum plate (150 C). We performed analysis of wound contraction, histology, immunohistochemistry, birefringence analysis, and immunoenzymatic assay to evaluate tissue quality. Our results demonstrate that the association of the techniques is able to accelerate the repair process, modulating the inflammatory process, presenting a cutaneous tissue with better quality. Thus, we conclude that the use of photobiomodulation therapy associated with cell therapy is a promising treatment in the repair of total thickness burns.

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“…Accordingly, since tryptase contributes to the pathogenesis of diabetes and its complexities, aiming MCs as a new remedy for diabetes needs more investigations [12]. In this context, it has been reported that the increased numbers of total MC density and degranulation in diabetic animals negatively affected the potentiometric properties of their skin wounds [13][14][15]. Recently, Wygrecka et al have suggested that MCs might provide to the fibrotic course by encouraging local fibroblasts in the lung, therefore leading to the pathogenesis of the illness [16].…”

Section: Discussionmentioning

confidence: 99%

Aerobic Exercise-Assisted Cardiac Regeneration by Inhibiting Tryptase Release in Mast Cells after Myocardial Infarction

Bayat

Chien

Chehelcheraghi

2021

BioMed Research International

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Background. Cardiovascular disease (CVD) contributes critically to the mortality, morbidity, and economic problem of illness globally. Exercise is a share of everyone’s life. Some evidence-based studies have frequently shown a progressive correlation between physical activity and good health. Objective. The effects of daily exercise on cardiomyocyte size, collagen content (fibrosis), and releasing mast cells (MCsʼ) tryptase of the model of myocardial infarction (MI) were assessed. Methods. 40 rats were coincidentally spread into sham+inertia (control), sham+exercise, infarction+inertia, and infarction+exercise groups. An experimental model of acute MI was induced in infarction groups. One week after surgery, exercising groups were allowed to an aerobic exercise program for six weeks. At the endpoint of the study, all examinations were performed. Results. We found lesser fibrosis in sham+exercise and infarction+exercise groups compared to sham+inertia and infarction+inertia groups, respectively ( p = 0.023 , p = 0.001 ). Also, infarction groups were significantly lower than sham groups ( p < 0.05 ) and the infarction+exercise group was significantly lower than the infarction+inertia group ( p < 0.05 ). The effect of exercise on MCs while increased MC density and degranulation occur at the site of fibrosis, we demonstrated that exercise decreases both total MC density and degranulation in both sham and infarction groups ( p < 0.05 ). Immunohistochemistry examinations were significantly higher expression of MCsʼ tryptase in infarction groups than sham groups ( p < 0.05 , p < 0.0001 ). Conclusion. Exercise improves fibrosis and cardiac function in both healthy and MI rats by inhibiting released MCsʼ tryptase.

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Effects of Photobiomodulation on Degranulation and Number of Mast Cells and Wound Strength in Skin Wound Healing of Streptozotocin-Induced Diabetic Rats

Cited by 37 publications

References 37 publications

“Photobiomics”: Can Light, Including Photobiomodulation, Alter the Microbiome?

“Photobiomics”: Can Light, Including Photobiomodulation, Alter the Microbiome?

Effect of photobiomodulation associated with cell therapy in the process of cutaneous regeneration in third degree burns in rats

Aerobic Exercise-Assisted Cardiac Regeneration by Inhibiting Tryptase Release in Mast Cells after Myocardial Infarction

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