Effects of Photoperiod on the Ultrastructure of Leydig Cells in Rat

Kuş, İlter; Songür, Ahmet; Özoğul, Candan; Kavakli, Ahmet; Zararsız, İsmail; Sarsılmaz, Mustafa

doi:10.1080/01485010490425476

Cited by 6 publications

(6 citation statements)

References 36 publications

(26 reference statements)

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“…Serum testosterone, testicular weight, diameter of seminiferous tubules, Leydig cell mitochondria and cytoplasmic secretory granules, sperm motility, viability and count are increased by long photoperiods [12,54,55]. All of these parameters decline with aging [56,57] along with the levels of TRH and TRH-like peptides in brain and peripheral tissues [3].…”

Section: Discussionmentioning

confidence: 99%

“…These circadian changes correlate with the co-release of glutamate from glutamatergic neurons and elevated ascorbate levels [2], the latter an essential cofactor in the post-translational processing of TRH and TRH-like peptide progenitor sequences [1,3]. The light/ dark cycle has major influences on cognitive [4,5], metabolic [6][7][8][9][10], reproductive [11,12], body weight [13][14][15], cardiovascular [16,17], immunologic [18][19][20][21][22][23], aging processes, and oxidative stress [6]. We felt that extension of our previous work to liver, pancreas, heart, testis, prostate, and epididymis might lead to the integration of TRH and TRH-like peptides into the expanding network of photoperiod-driven feedback loops [24] subject to disruption by the sleep and dietary dislocations of modern life.…”

Section: Introductionmentioning

confidence: 99%

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TRH and TRH-Like Peptide Levels Co-Vary with Reproductive and Metabolic Rhythms

Pekary

Sattin

2016

Horm Metab Res

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Photoperiod-synchronized rhythms in non-CSN tissues persist in total darkness. Clock genes involved in maintaining regular biorhythms within the suprachiasmatic nucleus (SCN) of the hypothalamus are expressed in extra-CNS tissues and continue periodic expression in vitro. Understanding the details of how the SCN clock is coupled with peripheral clocks is only incompletely understood and may involve a multiplicity of feedback systems. The present study is an extension of our previous work showing that brain levels of TRH (pGlu-His-Pro-NH) and TRH-like peptides (X-TRH: pGlu-X-Pro-NH, where "X" can be any amino acid residue) fluctuate throughout the day-night cycle. Male rats were maintained in a stable environment, lights on 6-18 h. TRH and TRH-like peptides in liver, pancreas, testis, prostate, epididymis, and heart were measured at 3, 10, 16, and 22 h. The greatest change in peptide level was a 12-fold increase for TRH in prostate at 16 h relative to the corresponding value at 3 h. The TRH, Tyr-TRH and Phe-TRH levels in liver declined steadily to about 40% of the 3-h values by 22 h. Changes, in the order of decreasing number of significant increases (↑) and/or decreases (↓), were: testis (5↑, 1↓), liver (3↓), epididymis (2↑), prostate (1↑, 1↓) and heart (1↑). Peptide levels in liver and testis correlated with serum leptin and serum corticosterone, respectively, which are potent releasers of these peptides. Testosterone and glucose were also highly correlated. These tripeptides may participate in the regulation of metabolic and reproductive functions, which change during the day-night cycle.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

TRH and TRH-Like Peptide Levels Co-Vary with Reproductive and Metabolic Rhythms

Pekary

Sattin

2016

Horm Metab Res

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“…Furthermore, long daylight exposure also promotes mitochondrial density in the testes of rats and bank voles, whereas the number of mitochondria decreases with short daylight exposure (Kus et al, 2004; Tahka, 1988). This may involve mitochondrial fission.…”

Section: Introductionmentioning

confidence: 99%

Effects of photoperiod on morphology and function in testis and epididymis of Cricetulus barabensis

Mou

Wang

et al. 2020

Journal Cellular Physiology

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Photoperiod regulates the seasonal reproductive rhythms of mammals by influencing the development and function of sexual organs; however, the underlying mechanism remains unclear. We examined the morphology and functioning of the main sex organs of striped dwarf hamsters (Cricetulus barabensis) under different photoperiods (short daylight [SD], moderate daylight [MD], and long daylight [LD]) and further investigated the underlying molecular mechanisms. There was an inverse correlation between blood melatonin levels and photoperiod in the order SD > MD > LD. Decreases in body and tissue weights were observed under SD, whereas testis and epididymis weights between MD and LD were comparable. The diameters of the spermatogenic tubules, thickness of the spermatogenic epithelium, and the number of spermatogonia and Sertoli cells decreased under SD, whereas the serumluteinizing hormone, follicle-stimulating hormone, and fecal testosterone concentrations decreased under LD. In SD, bax/bcl2 protein expression increased in the testes and decreased in the epididymides, whereas LC3II/LC3I remained unchanged in the testes and increased in the epididymides compared with the MD group. In LD, bax/bcl2 and LC3II/LC3I protein expression levels were unchanged in the testes but were decreased in the epididymides. In SD and LD, adenosine triphosphate synthase and citrate synthase protein expression levels were unchanged in the testes but were decreased in the epididymides. Drp1 and Mff protein expression increased in the testes and decreased in the epididymides. Overall, different regulatory mechanisms in the testis and epididymis led to degeneration under SD and maintenance under LD, preferentially protecting mitochondrial function in the testis by regulating mitochondrial fission.

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“…External factors often have an impact on testicular functioning. The photoperiod is one of these factors: long photoperiods increase testicular functioning, while short periods reduce it (8). In order to avoid any morphological changes among the groups caused by the various light amounts, all rats were exposed to the rotating 12-h light/12-h dark environment in the lab.…”

Section: Preparations For the Experimentsmentioning

confidence: 99%

How do vegetable oils (hazelnut and canola) affect the reproductive system in male rats?

Kati

Oğuz

Yılmaz

et al. 2018

Arch Ital Urol Androl

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No significant differences were noted with respect to behavior or weight among the three groups. Rats in the canola oil group (group III) had higher luteinizing hormone (LH) and higher testosterone levels than rats in the control group. Rats who received hazelnut oil (group II) exhibited similar findings, with these levels being higher than they were in the control group. No statistical differences were shown for histopathology or IHC testosterone antibody levels across all treatment groups. Conclussion: Canola oil was shown to have a greater effect on serum LH and testosterone compared to the control group and the group fed with hazelnut oil. Further investigation is required into how these oils affect serum hormone and sperm activity.

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Effects of Photoperiod on the Ultrastructure of Leydig Cells in Rat

Cited by 6 publications

References 36 publications

TRH and TRH-Like Peptide Levels Co-Vary with Reproductive and Metabolic Rhythms

TRH and TRH-Like Peptide Levels Co-Vary with Reproductive and Metabolic Rhythms

Effects of photoperiod on morphology and function in testis and epididymis of Cricetulus barabensis

How do vegetable oils (hazelnut and canola) affect the reproductive system in male rats?

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