Effects of physical activity on the deposition of traffic-related particles into the human lungs in silico

Oravisjärvi, Kati; Pietikäinen, Mari; Ruuskanen, Juhani; Rautio, Arja; Voutilainen, Arto; Keiski, Riitta L.

doi:10.1016/j.scitotenv.2011.07.020

Cited by 62 publications

(36 citation statements)

References 46 publications

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“…Secondly, some alterations in personal exposure as well as spatial variation of PM 10 can dramatically deteriorate gender differences of hospital admissions. Thirdly, the level of physical exercise and type of activities (e.g., sleeping, sitting, light exercise and heavy exercise) can affect the particle deposition in the human lungs as estimated by using traffic-related particles (Oravisjärvi et al, 2011). Fourthly, a previous study highlights the most evident health effect caused by multiple exposures to gases was upper respiratory track irritation, followed by the disruption of oxygen transport, and finally central nervous system disorders (Jumpponen et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

Hospital out-and-in-patients as Functions of Trace Gaseous Species and Other Meteorological Parameters in Chiang-Mai, Thailand

Pongpiachan

Paowa

2015

Aerosol Air Qual. Res.

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The aims of this study were to investigate the impact of meteorological parameters and trace gas concentrations on daily hospital walk-ins and admissions in Chiang-Mai province, Thailand, during 2007Thailand, during -2013. Advanced statistical models, including t-tests, Analysis of Variance (ANOVA), Multiple Linear Regression Analysis (MLRA) and Incremental Lifetime Particulate Matter Exposure (ILPE), were constructed using meteorological data from the Pollution Control Department (PCD), Ministry of Natural Resources and Environment (MNRE), Thailand, and the Thai Meteorological Department at Chiang-Mai Province Air Quality Observatory Site (TMCS) as well as the number of walk-in and admitted patients at Nakornping Hospital, Chiang-Mai (NHCM). The results showed that all trace gaseous species and PM 10 were significantly higher during the "haze episode" than during the "non-haze period." The FTIR spectra highlight the relatively homogeneous organic functional compositions of PM 2.5 collected from urban, suburban and rural observatory sites, indicating that agricultural waste burning plays an important role in air quality during the "haze episode." The effect of age on susceptibility to respiratory diseases was investigated by separating the dataset into four groups (i.e., < 15 years, 15-59 years, 60-74 years and ≥ 75 years). The ANOVA results revealed a significant increase in hospital walk-ins and admissions for both genders in the < 15 years group (p < 0.005). MLRA revealed the significantly highest impacts of CO on hospital walk-ins for both genders. The predicted ILPE of PM 10 showed the highest values for both genders during the "haze-episode" in 2007, with average values of 3.338 ± 0.576 g and 1.838 ± 0.317 g for male and female outdoor workers, respectively, over an exposure duration of 25 years.

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Section: Resultsmentioning

confidence: 99%

Hospital out-and-in-patients as Functions of Trace Gaseous Species and Other Meteorological Parameters in Chiang-Mai, Thailand

Pongpiachan

Paowa

2015

Aerosol Air Qual. Res.

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“…Long-term exposure to traffic-related air pollution may increase the risk of type 2 diabetes (Andersen et al, 2012; Kramer et al, 2010), and especially so in physically active individuals (Andersen et al, 2012). Physical activity may increase the penetration of traffic-related particles into the respiratory system, making physically active individuals more susceptible for traffic-related air pollution compared to inactive individuals (Oravisjarvi et al, 2011). Also, long-term exposure to traffic noise may be associated with increased risk of type 2 diabetes (Sorensen et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Neighborhood walkability, deprivation and incidence of type 2 diabetes: A population-based study on 512,061 Swedish adults

et al. 2015

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Neighborhood walkability has been associated with increased physical activity, but only a few studies have explored the association between walkability and health outcomes related to physical activity, such as type 2 diabetes. The aim of this study was to investigate the association between objectively assessed neighborhood walkability and the 4-year incidence of type 2 diabetes in a sample of 512,061 Swedish adults aged 18 years and older. Neighborhoods were defined by 408 administratively defined geographical areas in the city of Stockholm. We found a negative association between walkability and type 2 diabetes (OR=1.33, 95% CI=1.13–1.55) that remained significant after adjusting for neighborhood deprivation. This association, however, no longer remained statistically significant after adjusting for individual socio-demographic factors. These results were also confirmed using a co-sibling design. Future studies are encouraged to further explore the potential effect of a broader array of the neighborhood built environment on health outcomes related to physical activity.

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“…Some studies suggest that engaging in physical activity in polluted areas may reduce lung function [4, 5], increase airway inflammation [6], and increase the risk of developing asthma [7]. One possible explanation is that increased minute ventilation during exertion could lead to increased pollutant deposition in the lungs [8, 9]. Yet, the complex relationship between the benefits of regular physical activity and the risk associated with pollution exposure is not well understood.…”

Section: Introductionmentioning

confidence: 99%

Physical activity, black carbon exposure, and DNA methylation in the FOXP3 promoter

et al. 2017

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BackgroundPhysical activity is associated with improvement in lung function; however, pollution exposure during physical activity can lead to a transient reduction in lung function. This paradoxical relationship may be linked to altered T regulatory (Treg) cell activity, which increases with exercise and suppresses airway inflammation, but decreases in association with exposure to air pollution. To clarify these relationships, we investigated buccal cell DNA methylation of the forkhead box p3 (FOXP3) gene promoter, a proposed biomarker of Treg activity. We hypothesized that active urban children would have lower FOXP3 promoter methylation, associated with better lung function compared to non-active children. We also hypothesized that this relationship would be attenuated by high exposure to the air pollutant black carbon (BC).MethodsWe performed a cross-sectional study of 135 children ages 9–14 who live in New York City. Activity was measured across 6 days. BC exposure was assessed by personal monitors worn for two 24-h periods, followed by lung function assessment. Buccal swabs were collected for DNA methylation analysis of three regions (six CpG sites) in the FOXP3 promoter.ResultsIn multivariable regression models, overall, there was no significant relationship between physical activity and FOXP3 promoter methylation (p > 0.05). However, in stratified analyses, among children with higher BC exposure (≥1200 ng/m3), physical activity was associated with 2.37% lower methylation in promoter 2 (CpGs −77, −65, and −58) (β estimate = −2.37%, p < 0.01) but not among those with lower BC exposure (β estimate = 0.54%, p > 0.05). Differences across strata were statistically significant (p interaction = 0.04). Among all children, after controlling for BC concentration, promoter 2 methylation was associated with reduced FEV1/FVC (β estimate = −0.40%, p < 0.01) and reduced FEF25–75% (β estimate = −1.46%, p < 0.01).ConclusionsPhysical activity in urban children appeared associated with lower FOXP3 promoter methylation, a possible indicator of greater Treg function, under conditions of high BC exposure. Reduced FOXP3 promoter methylation was associated with higher lung function. These findings suggest that physical activity may induce immunologic benefits, particularly for urban children with greater risk of impaired lung function due to exposure to higher air pollution. FOXP3 promoter buccal cell methylation may function as a useful biomarker of that benefit.Electronic supplementary materialThe online version of this article (doi:10.1186/s13148-017-0364-0) contains supplementary material, which is available to authorized users.

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Effects of physical activity on the deposition of traffic-related particles into the human lungs in silico

Cited by 62 publications

References 46 publications

Hospital out-and-in-patients as Functions of Trace Gaseous Species and Other Meteorological Parameters in Chiang-Mai, Thailand

Hospital out-and-in-patients as Functions of Trace Gaseous Species and Other Meteorological Parameters in Chiang-Mai, Thailand

Neighborhood walkability, deprivation and incidence of type 2 diabetes: A population-based study on 512,061 Swedish adults

Physical activity, black carbon exposure, and DNA methylation in the FOXP3 promoter

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