Effects of physical properties for starch acetate powders on tableting

Abstract

The aim of the study was to investigate particle and powder properties of various starch acetate powders, to study the effect of these properties on direct compression characteristics, and to evaluate the modification opportunity of physical properties for starch acetate powders by using various drying methods. At the end of the production phase of starch acetate, the slurry of starch acetate was dried using various techniques. Particle, powder, and tableting properties of end products were investigated. Particle size, circularity, surface texture, water content and specific surface area varied according to the particular drying method of choice. However, all powders were freely flowing. Bulk and tapped densities of powders varied in the range of 0.29 to 0.44 g/cm 3 and 0.39 to 0.56 g/cm 3 , respectively. Compaction characteristics revealed that all powders were easily deformed under compression, having yield pressure values of less than 66 MPa according to Heckel analysis. All powders possessed a significant interparticulate bond-forming capacity during compaction. The tensile strength values of tablets varied between 10 and 18 MPa. In conclusion, physical properties of starch acetate could be affected by various drying techniques. A large specific surface area and water content above 4% were favorable properties by direct compression, especially for small, irregular, and rough particles.

Evaluation of Prosopis africana Seed Gum as an Extended Release Polymer for Tablet Formulation

“…Noteworthy, improvement in the flow rate of direct compression blend and granules has been observed, which may be attributed to interparticulate interaction as it directly influence bulk density of a powder and its flow (44). Similarly, increased tapped density for granules and direct compression blend indicated better degree of compactibility as a function of applied pressure (45,46).…”

Ultrasound Transmission Technique as a Potential Tool for Physical Evaluation of Monolithic Matrix Tablets

“…Moreover, it has been suggested (30) that these powders have numerous contact points and a large bonding surface area that form strong interparticular bonds between the particles, and thus, form firmer tablets at equal porosity. On the other hand, properties of powders with larger particle sizes are unfavorable for interparticular bond formation during compaction (30). An average of 131 m/s increase of ultrasound velocity was associated with increase of particle size fraction from 0-53 to 0-710 μm.…”

“…An increase in tablet porosity leads to decrease in its elastic modulus (29) and, thus, decrease in ultrasound velocity, as seen in the present study. In pharmaceutical materials, powders with smaller particle size, more irregular particle shape and larger specific surface area form tablets with lower porosities (30). Moreover, it has been suggested (30) that these powders have numerous contact points and a large bonding surface area that form strong interparticular bonds between the particles, and thus, form firmer tablets at equal porosity.…”

A Systematic Study on Processing Problems and <em>In vitro</em> Release of <em>Saraca indica</em> Caesalpiniaceae Bark Powder Tablets

“…Suboptimal presence of water diminishes the cohesiveness of powder, resulting in increased bulk density for granule and direct compression formulations and hence, enhanced flowability (17). On the other hand, increased tapped density of granule and direct compression formulation indicate better degree of compactibility as a function of applied pressure (18).…”