Effects of physical training on body composition and organ weights in ovariectomized and hyperestrogenic rats

Shinoda, Motoo; Mg, Latour; Jm, Lavoie

doi:10.1038/sj.ijo.0801900

Cited by 89 publications

(64 citation statements)

References 31 publications

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“…Progressive fat accumulation induces oxidative stress and was proven to cause obesity, hypertension and cardiovascular diseases (Park et al 2016). Previous study observed the weight gain in the ovariectomised rats are due to the oestrogen deficiency resulting an increase in the fat accumulation (Latour et al 2001, Shinoda et al 2002. However, the findings are not in line with the present results as Ovx+N group did not show any significance increase in the body weight compared to the sham group.…”

Section: Discussioncontrasting

confidence: 88%

Development of Hypertensive Animal Model Using Ovariectomised Rat Fed with Short-Term 2% Cholesterol Diet

Kumeshini¹,

Nurshazana²,

Othman³

et al. 2016

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ABSTRAKMenopaus merupakan pemberhentian pendarahan haid, ia secara langsung berkaitan dengan penyakit kardiovaskular (CVD) seperti tekanan darah tinggi dan strok. Pengurangan estrogen dan pengambilan diet berkolesterol tinggi mempunyai kesan yang menjejaskan fungsi kardiovaskular dan metabolisma pada wanita. Kajian ini bertujuan untuk menghasilkan model tikus hipertensi dalam tikus Sprague-Dawley terovariektomi yang diberi makan dengan 2% diet kolesterol dalam tempoh jangka pendek. Lapan belas tikus Sprague-Dawley dibahagikan secara rawak kepada tiga kumpulan iaitu kumpulan kawalan Sham (sham), kumpulan kawalan terovariektomi diberi diet normal (Ovx + N), tikus terovariektomi diberi diet kolesterol 2% (Ovx + Cho) selama empat minggu. Pada akhir kajian, pengambilan makanan dan berat badan diukur. Tekanan darah sistolik, diastolik dan tekanan min darah ditentukan. OVX + Cho menunjukkan peningkatan yang ketara dalam perubahan fisiologi seperti berat badan dan pengambilan makanan berbanding dengan kumpulan Ovx + N. Peningkatan yang ketara dalam tekanan darah sistolik, diastolik dan tekanan min darah diperhatikan dalam kumpulan Ovx + Cho. Berdasarkan hasil kajian di atas, dipercayai bahawa makanan berkolesterol selama empat minggu (jangka pendek) menyebabkan peningkatan ketara dalam tekanan darah, pengambilan makanan dan berat badan dalam tikus terovariektomi.Kata kunci: tekanan darah, berat badan, kolesterol, diet, terovariektomi, tikus ABSTRACT Menopause, a cessation of menstrual bleeding, is directly related to serious illness confined to cardiovascular disease (CVD) such as hypertension and 172 & Health 2016;11(2): 171-180 Kumeshini S. et al. diabetes, hypertension, heart diseases, osteoporosis and breast cancer (Bray 2003). Several experimental studies used ovariectomised rats as a menopausal model for the tentative researches (Leong et al. 2015). High Blood Pressure is defined as systolic blood pressure (SBP) greater than 140 mmHg and/or diastolic blood pressure (DBP) greater than 90 mmHg (Bray 2003). Increase in the blood pressure is the most common symptom in the CVD and is a main source of morbidity and mortality worldwide. Approximately, 90-95% cases of hypertension are idiopathic. It is a complex, multifactorial disorder, including genetic and lifestyle modifications (Leong et al. 2015). Based on the epidemiological surveys, several factors are linked with an increase in the blood pressure and these include age, sex, race, socioeconomic status, emotional disturbances, nutrition, stroke. The oestrogen withdrawal and consumption of high cholesterol diet has a detrimental effect on cardiovascular function and metabolism in menopausal women. The present study was aimed to develop the hypertensive rat model in the ovariectomised Sprague Dawley rats fed with 2% cholesterol diet following a short term period. Eighteen Sprague-Dawley rats were randomly divided into three groups; Sham control (sham), ovariectomized control fed with normal diet (Ovx +N), ovariectomized rats fed with 2% cholesterol diet (Ovx + Ch...

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Section: Discussioncontrasting

confidence: 88%

Development of Hypertensive Animal Model Using Ovariectomised Rat Fed with Short-Term 2% Cholesterol Diet

Kumeshini¹,

Nurshazana²,

Othman³

et al. 2016

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“…To estimate the bone mineral density of the proximal metaphysis of the tibia, computer-assisted tomography (CT) allowed determination of trabecular density of the metaphysis of the tibia. It is well documented that loss of estrogens results in increased fat accumulation in animals (23). In the same CT plane in which the tibial metaphysis was scanned a paratibial fat depot was visible, the surface of which could also be quantified.…”

Section: Introductionmentioning

confidence: 99%

Evidence for selective estrogen receptor modulator activity in a black cohosh (Cimicifuga racemosa) extract: comparison with estradiol-17beta

Seidlová-Wuttke

Hesse²,

Jarry³

et al. 2003

European Journal of Endocrinology

125

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Objective: Some phytoestrogens are believed to have selective estrogen receptor modulator (SERM) activity with no action in the uterus but beneficial effects in the hypothalamo/pituitary unit and in the bone and are presently the focus of clinical interest. In the present experiments, the effects of the clinically used Cimicifuga racemosa (CR) extract BNO 1055 in the uterus, in the bone and on serum luteinizing hormone (LH) were compared with the effects of estradiol-17b (E 2 ) under acute and chronic conditions in ovariectomized rats. Methods: Ovariectomized rats were treated either acutely (6 h) or chronically (3 months) with E 2 or the CR extract. Gene expression of some estrogen-regulated genes in the metaphysis of the tibia and the uterus was determined. Furthermore, bone mineral density was measured by quantitative computer tomography. Results: When given acutely, both E 2 and the CR extract inhibited LH secretion and slightly stimulated gene expression of IGF-I, collagen-1a1, osteoprotegerin and osteocalcin (all osteoblast products), and of tartrate-resistant acid phosphatase (TRAP, an osteoclast product) in the metaphysis of the femur. While E 2 stimulated uterine weight and expression of progesterone receptor (PR), the complement protein (C3) and IGF-I genes, and inhibited gene expression of the estrogen receptor b (ERb) in the uterus, no such effect was observed under acute CR treatment. After chronic application with pelleted food over 3 months E 2 had profound effects in the uterus on weight and gene expression (ERb, PR, C3 and IGF-I) which were not seen in the CR-treated animals. Within 3 months after ovariectomy, control rats had lost more than 50% of the metaphyseal bone mass of the tibia, an effect prevented by E 2 and partially by CR supplementation.

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“…Zhang et al 22 studied OVX and SHAM SpragueDawley rats and found that OVX reduced calcium absorption and balance, resulting in increased excretion of fecal calcium. They also found that OVX animals gained more weight, a fact reported in the literature for humans and animals 22,25 attributed to hormonal disorder and greater fat accumulation. Kobayashi et al 23 reported that Fisher rats had lower calcium balance than SHAM rats due to low intestinal absorption eight weeks after ovariectomy.…”

Section: Discussionmentioning

confidence: 65%

Calcium and caffeine interaction in increased calcium balance in ovariectomized rats

Silva

Costa

Franco³

et al. 2013

Rev. Nutr.

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OBJECTIVE: This study investigated the effects of caffeine intake associated with inadequate or adequate calcium intake in laparotomized or ovariectomized rats by means of the calcium balance. Forty adults Wistar rats were ovariectomized or laparotomized. METHODS: The animals (n=40) were randomly placed in eight groups receiving the AIN-93 diet with 100% or 50% of the recommended calcium intake with or without added caffeine (6mg/kg/day). The animals were kept in individuals metabolic cages at a temperature of 24°±2ºC, light/dark cycles of 12/12 hours, and deionized water available ad libitum. On the 8th week of the experiment, food consumption was measured and 24-hour urine and 4-day feces were collected to determine calcium balance [Balance=Ca intake-(Urinary Ca+Fecal Ca)]. RESULTS: Animals with adequate calcium intake presented higher balances and rates of calcium absorption and retention (p<0.05) than those with inadequate calcium intake, regardless of caffeine intake (p<0.05). Caffeine intake did not affect urinary calcium excretion but increased balance (p<0.05) in the groups with adequate calcium intake. CONCLUSION: Adequate calcium intake attenuated the negative effects of estrogen deficiency and improved calcium balance even in the presence of caffeine.

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Effects of physical training on body composition and organ weights in ovariectomized and hyperestrogenic rats

Cited by 89 publications

References 31 publications

Development of Hypertensive Animal Model Using Ovariectomised Rat Fed with Short-Term 2% Cholesterol Diet

Development of Hypertensive Animal Model Using Ovariectomised Rat Fed with Short-Term 2% Cholesterol Diet

Evidence for selective estrogen receptor modulator activity in a black cohosh (Cimicifuga racemosa) extract: comparison with estradiol-17beta

Calcium and caffeine interaction in increased calcium balance in ovariectomized rats

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