Effects of physical training on hormonal responses to exercise in asthmatic children.

Leisti, Seppo; Finnilä, M J; Kiuru, E

doi:10.1136/adc.54.7.524

Cited by 19 publications

(6 citation statements)

References 21 publications

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“…In addition, the horses in the present study had been in training for more than 20 weeks. Training significantly reduced the cortisol response to exercise in asthmatic children 54 ; however, there was no comparison with normal children in this particular study. In addition, the RAO horses in the present study had been maintained at pasture for at least 6 months prior to the study and were maintained on a minimum dust regimen for the duration of the study.…”

Section: Discussioncontrasting

confidence: 69%

Changes in plasma cortisol and ascorbic acid in horses with and without recurrent airway obstruction upon exercise and ascorbic acid supplementation

Cuff

Williams

Deaton

et al. 2005

Equine Comp. Exerc. Physiol.

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Diminished basal plasma cortisol concentrations and a blunted cortisol response to exercise have been observed in human asthmatics. In horses with recurrent airway obstruction (RAO), plasma concentrations of cortisol at rest are not significantly different from those of healthy horses, but the effect of exercise on endogenous cortisol concentrations has not been described. Ascorbic acid is a non-enzymatic antioxidant with proposed immune-modulating properties. In man, supplementation with ascorbic acid has been shown to attenuate the exercise-induced increase in plasma cortisol following prolonged, submaximal exercise. The relationship between cortisol and ascorbic acid has not previously been investigated in the horse. In a blinded cross-over design, five horses with RAO and six healthy non-RAO controls performed a standard exercise test following 4 weeks of supplementation with either an antioxidant (providing 10 mg ascorbic acid kg−1 day−1) or a placebo (<1 mg ascorbic acid kg−1 day−1). Venous blood samples were obtained 1 h prior to exercise and at 0, 15, 60 min and 24 h thereafter. Exercise resulted in a significant increase in plasma cortisol concentrations in both groups of horses (P<0.05). Basal and post-exercise concentrations of plasma cortisol in the RAO group (136±16 and 210±16 μmol l−1, respectively) were not significantly different from those in the non-RAO group (129±43 and 218±30 μmol l−1, respectively). Antioxidant supplementation increased basal and post-exercise concentrations of plasma ascorbic acid in RAO and non-RAO horses (P<0.05) but had no effect on plasma cortisol concentration in either group, before or after exercise (RAO: rest 157±27 μmol l−1, post-exercise 222±21 μmol l−1; non-RAO: rest 140±11 μmol l−1, post-exercise 227±35 μmol l−1). In conclusion, RAO-affected horses in remission demonstrate the same cortisol response to exercise as healthy controls. Antioxidant supplementation had no impact on post-exercise concentrations of plasma cortisol in either healthy or RAO-affected horses in remission.

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Section: Discussioncontrasting

confidence: 69%

Changes in plasma cortisol and ascorbic acid in horses with and without recurrent airway obstruction upon exercise and ascorbic acid supplementation

Cuff

Williams

Deaton

et al. 2005

Equine Comp. Exerc. Physiol.

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“…Cortisol response to the same absolute work load may fall (Leisti et al, 1979), but in response to the same relative exercise intensity, well controlled studies have shown both a clear potentiation of the plasma cortisol response after training (Bloom et al, 1976;Bullen et al, 1984) or no change (Hartley et al, 1972a(Hartley et al, , 1972b. The cortisol response during marathon running was shown in one study to be proportional to the degree of fitness of the runners (Dessypris et al, 1980) but other studies in trained athletes have failed to show any cortisol response to intensive, although often uncontrolled, exercise (Rose et al, 1970;Sutton et al, 1973;Sutton, 1978;Loucks & Horvath, 1984).…”

Section: Cortisol and Acthmentioning

confidence: 99%

Hormonal Responses to Exercise and Training: A Short Review

Howlett

1987

Clinical Endocrinology

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“…Several authors have described marked physical and/or psychological improvements following endurance training of asthmatic children (3)(4)(5)(6)(7), but few studies have demonstrated a beneficial effect on EIB. Oseid & Haaland (3) showed that, in some children, a 3-month conditioning programme resulted in a much slighter fall i n pulmonary function following exercise, whereas Fitch et al (5) found that the severity of EIB was unchanged after 5 months of swimming training of asthmatic children, despite an increase in working capacity.…”

mentioning

confidence: 99%

Effect of Physical Training on Exercise‐induced Bronchoconstriction

Henriksen

Nielsen

1983

Acta Paediatrica

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A 6-week period of physical training of 28 asthmatic children reduced the exercise-induced percentage fall in peak expiratory flow (from baseline) from 44 +/- 4% (mean +/- SE) to 30 +/- 4%. Resting pulmonary function was unchanged. Resting and maximum heart rate (submaximal treadmill running) and postexercise plasma lactate were all lowered by training. The individual values for exercise-induced bronchoconstriction and postexercise plasma lactate correlated positively before and after training. Furthermore, the training-induced reduction in these parameters correlated. In 14 asthmatic children, who served as controls, exercise-induced bronchoconstriction and physical fitness remained unchanged during a comparable period. The study demonstrates a beneficial effect of endurance training on exercise-induced bronchoconstriction and working capacity.

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Effects of physical training on hormonal responses to exercise in asthmatic children.

Cited by 19 publications

References 21 publications

Changes in plasma cortisol and ascorbic acid in horses with and without recurrent airway obstruction upon exercise and ascorbic acid supplementation

Changes in plasma cortisol and ascorbic acid in horses with and without recurrent airway obstruction upon exercise and ascorbic acid supplementation

Hormonal Responses to Exercise and Training: A Short Review

Effect of Physical Training on Exercise‐induced Bronchoconstriction

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