Effects of phytochemicals against diabetes

Bacanlı, Merve; Dilsiz, Sevtap Aydın; Başaran, Nurşen; Başaran, Ahmet

doi:10.1016/bs.afnr.2019.02.006

Cited by 59 publications

(33 citation statements)

References 136 publications

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“…They have been reported for their beneficial and therapeutic roles on diabetes in various studies. Phytochemical compounds such as lignans or flavonoids protect against oxidative stress and help diabetic wound healing (Bacanli et al, 2019). Bioactives, such as curcumin, capsaicin, berberine, celastrol, or artemisinin, were shown to improve insulin sensitivity to combat diabetes (Zhao et al, 2019).…”

Section: Other Chemicals and T2dmentioning

confidence: 99%

The Role of Nutrition in the Prevention and Intervention of Type 2 Diabetes

Guo

Huang

Sang

et al. 2020

Front. Bioeng. Biotechnol.

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Type 2 diabetes (T2D) is a rapidly growing epidemic, which leads to increased mortality rates and health care costs. Nutrients (namely, carbohydrates, fat, protein, mineral substances, and vitamin), sensing, and management are central to metabolic homeostasis, therefore presenting a leading factor contributing to T2D. Understanding the comprehensive effects and the underlying mechanisms of nutrition in regulating glucose metabolism and the interactions of diet with genetics, epigenetics, and gut microbiota is helpful for developing new strategies to prevent and treat T2D. In this review, we discuss different mechanistic pathways contributing to T2D and then summarize the current researches concerning associations between different nutrients intake and glucose homeostasis. We also explore the possible relationship between nutrients and genetic background, epigenetics, and metagenomics in terms of the susceptibility and treatment of T2D. For the specificity of individual, precision nutrition depends on the person's genotype, and microbiota is vital to the prevention and intervention of T2D.

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Section: Other Chemicals and T2dmentioning

confidence: 99%

The Role of Nutrition in the Prevention and Intervention of Type 2 Diabetes

Guo

Huang

Sang

et al. 2020

Front. Bioeng. Biotechnol.

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“…It is common for people to use natural plant medicine to prevent and/or treat diabetes in Central America, Asia, and West Africa. 29 According to an estimate published by the World Health Organization in 2008, about 80% of diabetic patients currently rely on medicinal plants for their successive treatments. 29,30 A wide variety of phytocompounds derived from medicinal plants, including flavonoids, polyphenols, terpenoids, alkaloids, saponins, quinones, polysaccharides, etc., have been intensively investigated for their antidiabetic effects.…”

Section: Main Antidiabetic Mechanisms Of Phytocompoundsmentioning

confidence: 99%

“…29 According to an estimate published by the World Health Organization in 2008, about 80% of diabetic patients currently rely on medicinal plants for their successive treatments. 29,30 A wide variety of phytocompounds derived from medicinal plants, including flavonoids, polyphenols, terpenoids, alkaloids, saponins, quinones, polysaccharides, etc., have been intensively investigated for their antidiabetic effects. 14,29,[31][32][33][34] The main mechanisms of phytocompounds for T2DM therapy might be based on four aspects involving certain key targets (Figure 1).…”

Section: Main Antidiabetic Mechanisms Of Phytocompoundsmentioning

confidence: 99%

“…29,30 A wide variety of phytocompounds derived from medicinal plants, including flavonoids, polyphenols, terpenoids, alkaloids, saponins, quinones, polysaccharides, etc., have been intensively investigated for their antidiabetic effects. 14,29,[31][32][33][34] The main mechanisms of phytocompounds for T2DM therapy might be based on four aspects involving certain key targets (Figure 1). 35 Under these conditions, phytocompounds can significantly reduce postprandial blood glucose levels by inhibiting αglucosidase and α-amylase.…”

Section: Main Antidiabetic Mechanisms Of Phytocompoundsmentioning

confidence: 99%

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<p>Oral Nano Drug Delivery Systems for the Treatment of Type 2 Diabetes Mellitus: An Available Administration Strategy for Antidiabetic Phytocompounds</p>

Nie¹,

Chen²,

Pang³

et al. 2020

IJN

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In view of the worldwide serious health threat of type 2 diabetes mellitus (T2DM), natural sources of chemotherapies have been corroborated as the promising alternatives, with the excellent antidiabetic activities, bio-safety, and more cost-effective properties. However, their clinical application is somewhat limited, because of the poor solubility, instability in the gastrointestinal tract (GIT), low bioavailability, and so on. Nowadays, to develop nanoscaled systems has become a prominent strategy to improve the drug delivery of phytochemicals. In this review, we primarily summarized the intervention mechanisms of phytocompounds against T2DM and presented the recent advances in various nanosystems of antidiabetic phytocompounds. Selected nanosystems were grouped depending on their classification and structures, including polymeric NPs, lipid-based nanosystems, vesicular systems, inorganic nanocarriers, and so on. Based on this review, the state-of-the-art nanosystems for phytocompounds in T2DM treatment have been presented, suggesting the preponderance and potential of nanotechnologies.

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“…It has become one of the major public health issues [2]. It has become the seventh leading cause of death worldwide [3]. Diabetes mellitus can be divided into two categories: type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) [4].…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic and antihyperlipidemic activities of Cucumis melo var. momordica fruit extract on experimental animals

Srivastava¹,

Mukerjee²,

Tripathi³

2020

Futur J Pharm Sci

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Background Diabetes mellitus is a major public health issue related to the irregular metabolism of carbohydrates, protein, and fat. It occurs due to insufficient insulin production and insulin action. Cucumis melo possesses several biological properties including antioxidant, anti-inflammatory, antibacterial, antihypothyroidism, and antiangiogenic activities. The objective of the present study was to determine the antidiabetic and antihyperlipidemic activities of Cucumis melo var. momordica fruit extract on experimental animals. Result Results show that treatment with C. melo fruit extract and fraction caused a reduction in blood glucose levels. Cucumis melo toluene fraction (CMTF) exhibited a significant (*P < 0.05) reduction of blood glucose level on the 28th day, i.e., 122 mg/dL, in comparison with the positive control group (streptozotocin (STZ)). However, the extract of C. melo showed less significant results in comparison with CMTF. Triglyceride, LDL, and VLDL levels were increased chronically due to STZ and were significantly (*P < 0.05) restored to 84.16, 86.97, and 19.73, respectively, by CMTF in comparison with the positive control group (STZ in the dose of 55 mg/kg). The extract-treated groups also showed similar results as CMTF, but their efficacy was lesser than CMTF. Conclusion It is can be concluded that C. melo fruits can be used as an effective antidiabetic and antihyperlipidemic drug. Graphical abstract

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Effects of phytochemicals against diabetes

Cited by 59 publications

References 136 publications

The Role of Nutrition in the Prevention and Intervention of Type 2 Diabetes

The Role of Nutrition in the Prevention and Intervention of Type 2 Diabetes

<p>Oral Nano Drug Delivery Systems for the Treatment of Type 2 Diabetes Mellitus: An Available Administration Strategy for Antidiabetic Phytocompounds</p>

Antidiabetic and antihyperlipidemic activities of Cucumis melo var. momordica fruit extract on experimental animals

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