Effects of phytosterols on markers of inflammation: A systematic review and meta-analysis

Antidiabetic Activity of Ergosterol from Pleurotus Ostreatus in KK‐Ay Mice with Spontaneous Type 2 Diabetes Mellitus

“…Phytosterols are a group of natural bioactive products mainly found in plants and have a similar structure to cholesterol, with no toxicity to humans and animals . Studies have reported that phytosterols can significantly reduce total cholesterol (TC) and low‐density lipoprotein cholesterol (LDL‐C) in the blood, and increase the index of high‐density lipoprotein cholesterol (HDL‐C)/LDL‐C and HDL‐C/TC …”

Development and characterization of phytosterol nanoemulsions and self-microemulsifying drug delivery systems

“…Phytosterols(PS) are triterpenes, an important component of plant cells, and are commonly found in seeds, vegetable oils and grains. Common in nature are β-sitosterol, campesterol, stigmasterol and ergosterol [1].It has the physiological functions of lowering blood lipid [2,3] , lowering cholesterol [4][5][6] , preventing cardiovascular disease [7],anti-cancer [8], anti-oxidation, scavenging free radicals [9,10], enhancing immunity [11], anti-inflammatory [12,13] and so on. Especially in reducing blood lipids, PS and cholesterol have similar molecular structure, which can competitively inhibit the absorption of cholesterol in the human intestinal tract, thereby reducing blood lipids [14].…”

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“…In this content, clinical study also suggested that consumption of phytosterol-β-sitosterol helps to decrease lipoproteins; although there was usually no change was observed in highdensity lipoprotein (HDL) 31 . In addition to above, β sitosterol exerts hypo-cholesterolemic effects by inhibiting the absorption of cholesterol in the intestine as well as competing by LDL-cholesterol and also decreases in total, along with LDLcholesterol concentrations 5-15% as evident from several studies 18 . This mechanism may be exerted by phytosterols of AVG in PCOS rodent model as demonstrated in our earlier report 10 .…”

“…Isolated phytosterols have modulatory action that can prevent visceral fat by improving hyperglycemia, hyperlipidemia and insulin resistance in metabolic syndrome 16 . Major phytocomponent, β sitosterol is known to regulate key molecules that is involved in inflammation, the immune response, anti-cancer defences, and apoptosis 17,18 .…”