Effects of Pistacia atlantica resin oil on the level of VEGF, hydroxyproline, antioxidant and wound healing activity in STZ-induced diabetic rats

Abstract

diabetes mellitus is a chronic metabolic disorder which is followed by many complications. one of these problems following diabetes is diabetic ulcers and 2.5% of diabetic patients develop foot ulcer annually. Natural resources are useful stock for finding traditional treatment. Studies which examined Pistacia atlantica properties showed that it has some beneficial effects including: antimicrobial, antifungal, antioxidant and wound healing. Yet, Pistacia atlantica resin oil effects on diabetic wound have not been examined. Therefore, we evaluate Pistacia atlantica resin oil antioxidant and wound healing activity. Sprague-Dawley male rats were entered to the study and randomly grouped (n = 10) as follows: group 1-control group-burnt rats which received neither STZ nor Pistacia atlantica resin oil; group 2-diabetic burnt rats; group 3-diabetic burnt rats which received 250 µl/day Pistacia atlantica resin oil topically as an ointment for two weeks. at the end of the study antioxidant status, Vascular Endothelial Growth Factor (VEGF) and hydroxyproline contents were examined in the wound area. Our results showed that Pistacia atlantica resin oil has remarkable antioxidant activity in STZ-induced diabetic rats. Also, it promoted VEGF and hydroxyproline contents in the wound area which showed that it increases angiogenesis and collagen turnover in the diabetic wound. We concluded that Pistacia atlantica resin oil can be considered as a new therapeutic agent in diabetic wound healing, and also it is safe, available and cheap treatment of other wounds and skin injuries.

Preparation of Codonopsis pilosula polysaccharide microcapsules and its effect and mechanism on skin wound healing in rats

“…51 Compared to the three groups, the Hyp content in the CPPM group was significantly higher (Figure 7(b)), indicating that CPPM can increase the Hyp content substantially in wound tissue samples and are useful for wound repair and healing. 52…”

“…51 Compared to the three groups, the Hyp content in the CPPM group was significantly higher (Figure 7(b)), indicating that CPPM can increase the Hyp content substantially in wound tissue samples and are useful for wound repair and healing. 52 The degree of health is closely related to the antioxidant capacity of its epidemic prevention system. 53 Figure 7 shows the results of total antioxidant capacity (T-AOC), glutathione peroxidase (GSH-Px), and lipid peroxide (LPO), respectively.…”

Antidiabetic, hypolipidemic, and antioxidant activities of Pistacia atlantica: A systematic review and meta‐analysis of preclinical studies

“…The flow chart of the search strategy followed by PRISMA is shown in Rouhi-Boroujeni et al, 2017;Sarir et al, 2018;Shahouzehi et al, 2018;Vazifeshenas-Darmiyan et al, 2016;Zarekar et al, 2014).…”

Pharmacological Investigation of Genus Pistacia

“…Therefore, medicinal plants are the best option to screen for the said action. The P. atlantica resin oil is the best wound healing agent in STZ-induced diabetic experimental rat [74]. No more studies are available for this activity.…”