Effects of Plasma Treatment on Wounds

Tipa, R. S.; Adamowicz, E. Stoffels

doi:10.1007/978-3-540-92841-6_342

Cited by 4 publications

(4 citation statements)

References 2 publications

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“…It has also been indicated that treated wounds started the proliferation phase 16 earlier than untreated ones. This phenomenon may be correlated with the proliferative effect of cold plasma, as reported previously 22 , and the early presence of myofibroblasts, as reported in this research.…”

Section: Discussionsupporting

confidence: 89%

“…Although the mechanism of the interaction between cold plasma and cells or living tissue is still unclear 21 , several studies have reported the effects of cold plasma on key wound-related cells or sub-cells, included promoting theproliferationoffibroblasts 22 and endothelial cells 23 , as well as the growth of epithelial cells 24 , inhibiting the migration of fibroblasts 25 and their surface expression 26 , and activating integrin of fibroblasts and epithelial cells 27 . Interestingly, some of these effects are likely to be similar to the activities of natural ROS and/or NO during wound healing, particularly cold plasma's effects on the proliferation of both fibroblasts and endothelial cells 19 .…”

Section: Introductionmentioning

confidence: 99%

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Cold plasma on full-thickness cutaneous wound accelerates healing through promoting inflammation, re-epithelialization and wound contraction

Nasruddin

Nakajima

Mukai

et al. 2014

Clinical Plasma Medicine

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We investigated cold plasma effects on acute wounds of mice. The mice were classified into experimental and control groups. In the former, wounds were treated using cold plasma once daily for 1 minute, and then covered with hydrocolloid dressing; wounds in the control were left to heal under hydrocolloid dressing. Daily evaluation was conducted for 15 days. General and specific staining was applied to evaluate re-epithelialization, neutrophil, macrophage, myofibroblast and transforming growth factor beta. It was found that cold plasma accelerated wound healing by one day. Plasma may promote the late phase of inflammation, accelerate reepithelialization and increase wound contraction.3

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Cold plasma on full-thickness cutaneous wound accelerates healing through promoting inflammation, re-epithelialization and wound contraction

Nasruddin

Nakajima

Mukai

et al. 2014

Clinical Plasma Medicine

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“…In recent years, plasma sources for wound treatment have been developed and tested at several centres [43][44][45][46] . Two advantages of physical procedures are the fact that they can be standardized and the absence of entry of the antiseptic into the wound.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Chlorhexidine, Polihexanide and Tissue-Tolerable Plasma against Pseudomonas aeruginosa Biofilms Grown on Polystyrene and Silicone Materials

Hübner¹,

Matthes²,

Koban

et al. 2010

Skin Pharmacol Physiol

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Background: The formation of biofilms is crucial in the pathogenesis of many acute and subacute microbial infections, including chronic wounds and foreign-body-related infections. Topical antimicrobial therapy with chemical antiseptics or physical treatment with tissue-tolerable plasma (TTP) may be promising to control bacterial infection. Methods: We assessed the efficacy of 0.1% chlorhexidine digluconate (CHX), 0.02 and 0.04% polihexanide (polyhexamethylene biguanide, PHMB) and of TTP against Pseudomonas aeruginosa SG81 biofilm grown in microtitre plates (polystyrene) and on silicone materials in an artificial wound fluid. Results: Overall, PHMB was as effective as CHX in reducing the total amount of biofilm (gentian violet assay) and in reducing the bacterial metabolism in biofilms (XTT assay). TTP also led to a significant reduction in colony-forming units. Conclusion: The antimicrobial activity of PHMB in biofilms is comparable to that of CHX. TTP could become an interesting physical alternative to chemical antisepsis in the future.

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“…The field of plasma medicine possesses a high innovation potential and the treatment of chronic wounds with plasma is particularly promising as numerous studies have suggested in vitro and in vivo . In addition to the plasma's antiseptic activity, some cells are eliminated by plasma‐induced apoptosis, and the proliferation and migration of fibroblasts and keratinocytes as well as angiogenesis is promoted . Mild inflammatory stimuli in, for example, immune cells and skin cells, may help the chronic wound to transit from stagnation into the phase of acute inflammation, to subsequently mediate wound healing.…”

Section: Plasma Medicinementioning

confidence: 99%

Cold Physical Plasmas in the Field of Hygiene—Relevance, Significance, and Future Applications

Krämer

Bekeschus

Matthes

et al. 2015

Plasma Processes & Polymers

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Cold physical plasmas ignited a technological spark in industry, biotechnology, and medicine. Especially the field of hygiene benefited of the plasma's exceptional activity against pathogenic microorganisms. Together with plasma-based surface functionalization, these qualities are highly relevant in a variety of processes in health care, such as the decontamination or sterilization of medical devices, food, packaging materials, waste water, or indoor air. In medicine, plasma has proven to show promising antiseptic results on skin and mucosal membranes in infection-related diseases in dermatology and dentistry. This comprehensive review will discuss the current applications of cold plasma in the fields of hygiene, and will provide a promising outlook on many applications yet to come.

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Effects of Plasma Treatment on Wounds

Cited by 4 publications

References 2 publications

Cold plasma on full-thickness cutaneous wound accelerates healing through promoting inflammation, re-epithelialization and wound contraction

Cold plasma on full-thickness cutaneous wound accelerates healing through promoting inflammation, re-epithelialization and wound contraction

Efficacy of Chlorhexidine, Polihexanide and Tissue-Tolerable Plasma against Pseudomonas aeruginosa Biofilms Grown on Polystyrene and Silicone Materials

Cold Physical Plasmas in the Field of Hygiene—Relevance, Significance, and Future Applications

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