Effects of plasmapheresis and autotransfusion on complement recovery in dogs

Large Animal Models for Simulating Physiology of Transfusion of Red Cell Concentrates—A Scoping Review of The Literature

“…However, the study by Muenster et al exposed erythrocyte concentrates to oxygen or nitric oxide prior to transfusion [21]. (C) In 13 out of the 36 included studies, a total of 440 dogs were included, with only three studies describing a repeated use of the same animals [14,[42][43][44][45][46][47][48][49][50][51][52][53]. Study populations showed similar ranges compared to the other two species, with studies using six to 76 dogs per study [14,[42][43][44][45][46][47][48][49][50][51][52][53].…”

“…(C) In 13 out of the 36 included studies, a total of 440 dogs were included, with only three studies describing a repeated use of the same animals [14,[42][43][44][45][46][47][48][49][50][51][52][53]. Study populations showed similar ranges compared to the other two species, with studies using six to 76 dogs per study [14,[42][43][44][45][46][47][48][49][50][51][52][53]. In three out of 13 publications, male and female dogs were included in the same study [42,50,53].…”

“…For all studies in pigs and sheep, animals of only one sex were used for each study. However, the studies utilizing canine models were markedly dominated by male dogs [42,[50][51][52][53]. Beagles were preferably chosen as a breed, with seven publications providing data in this regard [14,[43][44][45][46][47][48].…”

“…Of the included studies, six publications reported the transfusion of canine red blood cell concentrates in a model of pneumonia [14,43,[45][46][47][48]. Furthermore, three studies described the use of a hemorrhagic shock model [44,51,52]. However, two papers reported an application of erythrocytes in a top-load transfusion model, and none of the reviewed studies used healthy dogs [14,[42][43][44][45][46][47][48][49][50][51][52][53].…”

“…Furthermore, three studies described the use of a hemorrhagic shock model [44,51,52]. However, two papers reported an application of erythrocytes in a top-load transfusion model, and none of the reviewed studies used healthy dogs [14,[42][43][44][45][46][47][48][49][50][51][52][53].…”