Effects of Plasmodium yoelii nigeriensis infection on Anopheles stephensl egg development and resorption

Carwardine, S. L.; Hurd, H.

doi:10.1111/j.1365-2915.1997.tb00405.x

Cited by 28 publications

(19 citation statements)

References 6 publications

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“…Sporozoite infection of the salivary glands can result in increased feeding mortality when infectious [54,55]. Fecundity can be affected as smaller egg-batch size is observed due to maturing oocysts [56] but not salivary-gland sporozoites [57]. Once infectious, a mosquito's bites have a probability of infecting a human host, whether the mosquito survives the feed or dies during or after the feed.…”

Section: Methods: Model Designmentioning

confidence: 99%

A malaria transmission-directed model of mosquito life cycle and ecology

Eckhoff

2011

Malar J

165

187

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BackgroundMalaria is a major public health issue in much of the world, and the mosquito vectors which drive transmission are key targets for interventions. Mathematical models for planning malaria eradication benefit from detailed representations of local mosquito populations, their natural dynamics and their response to campaign pressures.MethodsA new model is presented for mosquito population dynamics, effects of weather, and impacts of multiple simultaneous interventions. This model is then embedded in a large-scale individual-based simulation and results for local elimination of malaria are discussed. Mosquito population behaviours, such as anthropophily and indoor feeding, are included to study their effect upon the efficacy of vector control-based elimination campaigns.ResultsResults for vector control tools, such as bed nets, indoor spraying, larval control and space spraying, both alone and in combination, are displayed for a single-location simulation with vector species and seasonality characteristic of central Tanzania, varying baseline transmission intensity and vector bionomics. The sensitivities to habitat type, anthropophily, indoor feeding, and baseline transmission intensity are explored.ConclusionsThe ability to model a spectrum of local vector species with different ecologies and behaviours allows local customization of packages of interventions and exploration of the effect of proposed new tools.

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Section: Methods: Model Designmentioning

confidence: 99%

A malaria transmission-directed model of mosquito life cycle and ecology

Eckhoff

2011

Malar J

165

187

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“…The developmental pauses, unique pattern of hormonal secretions and discrete feeding habits of anautogenic mosquitoes have made a regulatory scheme based on nutrition production and JH synthesis more difficult to define. Thus, oosorption in mosquitoes has only been well-described after a blood meal (Carwardine and Hurd 1997; Clements and Boocock, 1984; Uchida et al, 2004); the highest rates of oosorption are seen during this time when up to 27% of follicles will become resorbed despite advanced vitellogenic development (Clements and Boocock, 1984). Follicular resorption after a blood meal can be greatly increased by Plasmodium infection in Anopheline spp .…”

Section: Introductionmentioning

confidence: 99%

Nutrient limitation results in juvenile hormone-mediated resorption of previtellogenic ovarian follicles in mosquitoes

Clifton

Noriega

2011

Journal of Insect Physiology

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Juvenile hormone (JH) is a central hormonal regulator of previtellogenic development in female Aedes aegypti mosquitoes. JH levels are low at eclosion and increase during the first day after adult emergence. This initial rise in JH is essential for female reproductive maturation. After previtellogenic maturation is complete, the mosquito enters a ‘state-of-arrest’ during which JH synthesis continues at a slower pace and further ovary development is repressed until a blood meal is taken. By examining the relationships between juvenile hormone, follicular resorption and nutrition in A. aegypti, we were able to define a critical role of JH during the previtellogenic resting stage. The rate of follicular resorption in resting stage mosquitoes is dependent on nutritional quality. Feeding water alone caused the rate of follicular resorption to reach over 20% by day 7 after emergence. Conversely, feeding a 20% sucrose solution caused resorption to remain below 5% during the entire experimental period. Mosquitoes fed 3% sucrose show rates of resorption intermediate between water and 20% sucrose and only reached 10% by day 7 after emergence. Follicular resorption is related to JH levels. Ligated abdomens separated from a source of JH (the corpora allata) showed an increase in resorption comparable to similarly aged starved mosquitoes (16%). Resorption in ligated abdomens was reduced to 6% by application of methoprene. The application of methoprene was also sufficient to prevent resorption in intact mosquitoes starved for 48 hours (14% starved vs. 4% starved with methoprene). Additionally, active caspases were localized to resorbing follicles indicating that an apoptotic cell-death mechanism is responsible for follicular resorption during the previtellogenic resting stage. Taken together, these results indicate that JH mediates reproductive trade-offs in resting stage mosquitoes in response to nutrition.

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“…Second, there is evidence from rodent malaria suggesting that Plasmodium induces a direct cost on female fecundity. Plasmodium yoelii induces apoptosis in mosquito ovaries [61] and increases egg resorption [62]. Although no molecule of Plasmodium origin has been identified that would justify talking about parasite manipulation, it has been widely assumed that reproductive curtailment is an adaptive strategy of the parasite to increase mosquito survival through a trade-off in energy allocation between reproduction and survival [63,64].…”

Section: (D) Mosquito Fitnessmentioning

confidence: 99%

Avian malaria: a new lease of life for an old experimental model to study the evolutionary ecology ofPlasmodium

Pigeault

Vézilier

Cornet

et al. 2015

Phil. Trans. R. Soc. B

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One contribution of 17 to a theme issue 'Within-host dynamics of infection: from ecological insights to evolutionary predictions'. Avian malaria has historically played an important role as a model in the study of human malaria, being a stimulus for the development of medical parasitology. Avian malaria has recently come back to the research scene as a unique animal model to understand the ecology and evolution of the disease, both in the field and in the laboratory. Avian malaria is highly prevalent in birds and mosquitoes around the world and is amenable to laboratory experimentation at each stage of the parasite's life cycle. Here, we take stock of 5 years of experimental laboratory research carried out using Plasmodium relictum SGS1, the most prevalent avian malaria lineage in Europe, and its natural vector, the mosquito Culex pipiens. For this purpose, we compile and analyse data obtained in our laboratory in 14 different experiments. We provide statistical relationships between different infection-related parameters, including parasitaemia, gametocytaemia, host morbidity (anaemia) and transmission rates to mosquitoes. This analysis provides a wide-ranging picture of the within-host and between-host parameters that may bear on malaria transmission and epidemiology.

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Effects of Plasmodium yoelii nigeriensis infection on Anopheles stephensl egg development and resorption

Cited by 28 publications

References 6 publications

A malaria transmission-directed model of mosquito life cycle and ecology

A malaria transmission-directed model of mosquito life cycle and ecology

Nutrient limitation results in juvenile hormone-mediated resorption of previtellogenic ovarian follicles in mosquitoes

Avian malaria: a new lease of life for an old experimental model to study the evolutionary ecology ofPlasmodium

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