Effects of platelet-activating factor on cardiovascular function, oxygen free radical status, and blood chemistry

Prasad, Kailash; Gupta, Jang B.; Kalra, Jawahar

doi:10.1007/bf02014905

Cited by 2 publications

(1 citation statement)

References 44 publications

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“…Evidence suggests that PAF is involved in the pathophysiology of hemorrhagic shock [90±92]. PAF produces cardiac depression and decreases in arterial pressure, and these eects are associated with an increase in the oxidative stress [93,94]. Increase in the oxidative stress by PAF could be due to the stimulation of PMNLs.…”

Section: Platelet-activating Factor (Paf)mentioning

confidence: 99%

Role of oxyradicals in the pathophysiology of hemorrhagic shock

Prasad

Lee

2011

Int J Angiol

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Oxyradicals have been implicated in the pathophysiology of numerous diseases. This review describes the role of oxyradicals in cardiovascular depression and cellular injury during hemorrhagic shock and reinfusion. Clinical classi®cation of shock has been provided. Physiological basis of signs and symptoms of hemorrhagic shock has been tabled. This review provides data that the cardiac function and contractility are depressed during shock and reinfusion. The cardiac depression is associated with increases in the lipid peroxidation product malodialdehyde (MDA), in the oxygen radical producing activity of polymorphonuclear leukocytes, and the activity of plasma creatine kinase and CKMB. Also the antioxidant reserve is depressed in the myocardium. Antioxidant enzyme activity is aected adversely. Pretreatment with antioxidants retards the cardiac depression and reduces oxidative stress. In this respect polymorphonuclear leukocytes play a role in the cardiac depression in hemorrhagic shock and reinfusion. The increase in the vascular resistance appears to be associated with oxidative stress. The data to-date suggest that oxyradicals play a role in the cardiac depression and cellular injury during hemorrhagic shock and reinfusion and that the antioxidant treatment may be bene®cial in hemorrhagic shock and reinfusion.

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Section: Platelet-activating Factor (Paf)mentioning

confidence: 99%

Role of oxyradicals in the pathophysiology of hemorrhagic shock

Prasad

Lee

2011

Int J Angiol

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Oxygen Free Radicals and Endotoxic Shock: Effect of Flaxseed

Pattanaik

Prasad

1998

J Cardiovasc Pharmacol Ther

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BACKGROUND: Cardiac dysfunction and tissue injury during endotoxemia may be caused by increased levels of oxygen free radicals. METHODS AND RESULTS: We therefore investigated the effects of endotoxic shock on cardiac function and contractility, plasma creatine kinase (CK) activity and lactate concentration, oxyradical-producing activity of polymorphonuclear leukocytes (PMNL-CL) and white blood corpuscles, antioxidant reserve (cardiac chemiluminescence [LV-CL]), antioxidant enzyme activity (superoxide dismutase, catalase, glutathione peroxidase), cardiac malondialdehyde (MDA) concentration, a lipid peroxidation product, and hemodynamics in the absence or presence of flaxseed treatment in anesthetized dogs. Flaxseed contains lignans that have antioxidant activites and inhibit platelet-activating factor (PAF). The dogs were assigned to three groups: group I, sham control; group II, endotoxin (ET) treated (5 mg/kg intravenously); group III, ET + flaxseed (2 gm/kg/day orally) for 6 days. ET produced a decrease in cardiac function and contractility and antioxidant enzyme levels, and an increase in cardiac MDA and LV-CL, PMNL-CL, and plasma CK and lactate. Pretreatment with flaxseed attenuated the ET-induced cardiac dysfunction and cellular damage. Protection was incomplete for cardiovascular function, plasma CK, and lactate. CONCLUSIONS: These results suggest that oxyradicals and/or PAF may be involved in the deterioration of cardiovascular function and cellular integrity during ET shock and that antioxidant and anti-PAF agents may be effective in the treatment of ET shock.

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Effects of platelet-activating factor on cardiovascular function, oxygen free radical status, and blood chemistry

Cited by 2 publications

References 44 publications

Role of oxyradicals in the pathophysiology of hemorrhagic shock

Role of oxyradicals in the pathophysiology of hemorrhagic shock

Oxygen Free Radicals and Endotoxic Shock: Effect of Flaxseed

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