Effects of platelet-rich plasma (PRP) on cutaneous regeneration and wound healing in dogs treated with dexamethasone

Autologous Platelet Gel to Treat Chronic Decubital Ulcers: A Randomized, Blind Controlled Clinical Trial in Dogs

“…Although several recent in vivo studies corroborate our findings, there are conflicting observations . In those studies, no benefit after topical application of PG was identified in tendon injuries, bone defects, and skin or palatal wounds in dogs, or in porcine intestinal or equine skin wounds. These studies evaluated the effects of PG in acute and experimentally induced injuries, whereas we studied chronic decubital ulcers in dogs.…”

“…), ophthalmic surgery (for corneal ulcers), and cutaneous ulcers (for decubitus and/or diabetic sores) . Despite a growing interest on clinical application of PG we are unaware of any randomized controlled clinical trials using PG on chronic, bilateral, decubital ulcers in dogs.…”

Effect of locally injected autologous platelet-rich plasma on second intention wound healing of acute full-thickness skin defects in dogs

“…In a similar experimental study in rabbits in acute wounds treated with PRP, a trend towards increased angiogenic response and epithelialization was reported, whereas in our study no significant differences in these variables were found between PRPtreated and control wounds (15). In dogs treated with dexamethasone (impaired healing), in which the efficacy of PRP on the healing of 2x2 cm full-thickness skin wounds was examined, no significant differences were found between treated wounds and untreated controls either in the healing rate as in our study or the evaluated histological variables (fibroblast proliferation and collagen production) (23).…”

“…The release of bioactive proteins (growth factors and cytokines) from platelets and consequently the effectiveness of PRP depends on platelets activation (31,32). In most studies evaluating the effect of PRP on second intention wound healing, PRP was just applied on the wound surface; in those cases, activation of platelets was achieved by the addition of thrombin or calcium chloride before application (13,15,23,24,33). In the present study, however, we used the intra-lesional (at the wound Table 3 Histological variables during the healing process in plateletrich plasma-treated and untreated (control) wounds in dogs.…”

“…In veterinary medicine, the effect of PRP on cutaneous wound healing has been mainly evaluated in horses (21,22). In the canine species, the efficacy of PRP on skin wound repair has been recently examined in an experimental study in dogs treated with dexamethasone, which is considered as a negative factor for normal healing (23). Furthermore, autologous platelet gel applied on chronic protracted decubital ulcers was evaluated in 18 dogs and resulted in more rapid healing compared to control wounds (24).…”