Effects of pollutant atmospheres on surface receptors of pulmonary macrophages

Prasad, Shanker B.; Rao, V. Sree Hari; Mannix, Richard C.; Phalen, Robert F.

doi:10.1080/15287398809531169

Cited by 33 publications

(23 citation statements)

References 33 publications

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“…We have previously reported similar toxic effects produced by ozone and ozone-containinq multicomponent atmospheres (Prasad et al, 1988). Although the mechanism(s) that induces this phenomenon is not clearly understood, it has been hypothesized that soluble immune complexes and suppressor T cells may play significant roles (Rao et al, 1979a;Rao et al, 1979b;Rao et al, 1980 …”

Section: Particle Clearancementioning

confidence: 96%

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Toxic Effects of Short-Term Exposures to Acids and Diesel Exhaust

Prasad¹,

Rao²,

McClure³

et al. 1990

Journal of Aerosol Medicine

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Section: Particle Clearancementioning

confidence: 96%

“…we (Prasad et al, 1988) This exposure system has been described in detail previously (Prasad et al, 1988 Figure 1.) The fuel used was Phillips #2 Diesel Control Fuel.…”

Section: Previous Studiesmentioning

confidence: 99%

Toxic Effects of Short-Term Exposures to Acids and Diesel Exhaust

Prasad¹,

Rao²,

McClure³

et al. 1990

Journal of Aerosol Medicine

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“…Infections are a problem because they may artifactually change (most likely slow) particle clearance rates (Pavia et al, 1980). The methods used in performing the study were similar to those used in our concurrent rat studies (Mannix et al, 1983;Prasad et al, 1988). Three groups of 10 ferrets each were exposed nose-only to the following atmospheres for 4 h: purified air; 0.5 mg/m3 H, SO, ; 1.0 mg/m3 H,SO,.…”

Section: Methodsmentioning

confidence: 99%

Effects of Sulfuric Acid on Ferret Respiratory Tract Clearance

Mannix¹,

Phalen²,

Nguyen³

1991

Inhalation Toxicology

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I NTRO D U CTI 0 NMany animal species have been successfully used as models by toxicologists in respiratory tract deposition and clearance studies. Among these are rabbits (Chen and Schlesinger, 1983;Schlesinger, 1990), dogs (Wolff et al., 1981), donkeys (Schlesinger et al., 1979), rats (Kenoyer et al., 1981;Mannix et al., 1983), sheep (Sackner et al., 1981, mice (Fairchild et al., 1975), guinea pigs , and hamsters (Harbison and Brain, 1983). When selecting an animal model for a particular clearance study, the investigators must consider many practical factors, including the cost of purchasing and housing (feeding, etc.) the animals, the number of animals that would be required to observe a significant physiological effect, and the ease of performing the measurements. Most im- portantly, the anatomical and physiological similarity of the respiratory system of the animal to the human respiratory system, and the availability of healthy animals, are key features for many studies.

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“…Changes in functional characteristics of alveolar macrophages (1 2 rats/ atmosphere) were quantified by a rosette assay (Prasad et al, 1988;Kleinman et al, 1993) for determining Fc receptor binding capacity, and by determination of the production of superoxide anion during respiratory burst activity. To measure the ability of macrophages to bind sheep red blood cells (SRBCs) to Fc receptors, adherent macrophages ( l o 5 cells) were incubated in eightwell microtiter chambers (Fisher Scientific, Tustin, CA) with rat anti-sheep red blood cell antibody (30 min at 37°C) to allow the antibody to bind to the macrophage Fc receptors.…”

Section: Macrophage Function Analysismentioning

confidence: 99%