Effects of poly(vinylpyrrolidone) and ethylcellulose on alginate microspheres prepared by emulsification

Chan, Lai Wah; Heng, Paul Wan Sia

doi:10.3109/02652049809006868

Cited by 30 publications

(15 citation statements)

References 19 publications

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“…Ironcross-linked hydroxamated alginic acid has proved to be successful in prolonging drug release of a number of compounds (27). The drug release profiles of calcium alginate microspheres loaded with sulfaguanidine were affected by addition of various copolymers (28,29). It was demonstrated that some cellulose derivatives produced a marked aggregation of the microspheres.…”

Section: Diffusion Systemsmentioning

confidence: 99%

“…It was demonstrated that some cellulose derivatives produced a marked aggregation of the microspheres. Of the cellulose derivatives only ethyl cellulose and hydroxypropyl cellulose resulted in a decrease in drug release rate (28)(29)(30)(31). For these preparations the retardation in drug release was attributed to the aggregate formation.…”

Section: Diffusion Systemsmentioning

confidence: 99%

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Alginate in Drug Delivery Systems

Tønnesen

Karlsen

2002

Drug Development and Industrial Pharmacy

1,289

613

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Alginates are established among the most versatile biopolymers, used in a wide range of applications. The conventional use of alginate as an excipient in drug products generally depends on the thickening, gel-forming, and stabilizing properties. A need for prolonged and better control of drug administration has increased the demand for tailor-made polymers. Hydrocolloids like alginate can play a significant role in the design of a controlled-release product. At low pH hydration of alginic acid leads to the formation of a high-viscosity ''acid gel.'' Alginate is also easily gelled in the presence of a divalent cation as the calcium ion. Dried sodium alginate beads reswell, creating a diffusion barrier decreasing the migration of small molecules (e.g., drugs). The ability of alginate to form two types of gel dependent on pH, i.e., an acid gel and an ionotropic gel, gives the polymer unique properties compared to neutral macromolecules. The molecule can be tailor-made for a number of applications. So far more than 200 different alginate grades and a number of alginate salts are manufactured. The potential use of the various qualities as pharmaceutical excipients has not been evaluated fully, but alginate is likely to make an important contribution in the development of polymeric delivery systems. This natural polymer is adopted by Ph.Eur. It can be obtained in an ultrapure form suitable for implants. This review discusses the present use and future possibilities of alginate as a tool in drug formulation.

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Section: Diffusion Systemsmentioning

confidence: 99%

Section: Diffusion Systemsmentioning

confidence: 99%

Alginate in Drug Delivery Systems

Tønnesen

Karlsen

2002

Drug Development and Industrial Pharmacy

1,289

613

View full text Add to dashboard Cite

show abstract

“…[51] 13-Magnetic microspheres carriers of contraceptive has been designed responsive to the changes in steroid secretions during menstrual cycle. [52] www.wjpps.com Vol 6, Issue 9, 2017. 108…”

Section: Farah World Journal Of Pharmacy and Pharmaceutical Sciencesmentioning

confidence: 99%

Magnetic Microspheres: A Novel Drug Delivery System

Farah¹

2017

WJPPS

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A well designed controlled drug delivery system can provide a therapeutic amount of drug to the proper site in the body and then maintain the desired drug concentration for the specific period of time.A number of approaches are available in delivering therapeutic substance to the target site in sustained and controlled release fashion.One such approach is using magnetic microspheres as carriers for drugs. Microsphere drug delivery system has gained vast attention due to its diverse applications that range from targeting the drug to specific site to imaging and helping the diagnostic features. One of its important application is that it is used for targeting tumors using anticancer drugs. Being more stable, it has an advantage over other delivery systems like liposomes. The main objectives of this review is to highlight some important aspects of magnetic microspheres as a novel drug delivery system. The review shall cover definitions, concepts, types, mechanism of targeting, evaluation and characteristics of magnetic microspheres as well as various methods and techniques used in their preparations. The review also entails various applications and future prospects of magnetic microspheres.

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“…Magnetic microspheres carriers of contraceptive has been designed responsive to the changes in steroid secretions during menstrual cycle [50].…”

Section: Applications Of Magnetic Microspheresmentioning

confidence: 99%

Magnetic Microspheres: A Novel Drug Delivery System

Farah

2016

JAPLR

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A well designed controlled drug delivery system can provide a therapeutic amount of drug to the proper site in the body and then maintain the desired drug concentration for the specific period of time. A number of approaches are available in delivering therapeutic substance to the target site in sustained and controlled release fashion. One such approach is using magnetic microspheres as carriers for drugs. Microsphere drug delivery system has gained vast attention due to its diverse applications that range from targeting the drug to specific site to imaging and helping the diagnostic features.One of its important application is that it is used for targeting tumors using anticancer drugs. Being more stable, it has an advantage over other delivery systems like liposomes. The main objectives of this review are to highlight some important aspects of magnetic microspheres as a novel drug delivery system. The review shall cover definitions, concepts, types, mechanism of targeting, evaluation and characteristics of magnetic microspheres as well as various methods and techniques used in their preparations. The review also entails various applications and future prospects of magnetic microspheres.

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Effects of poly(vinylpyrrolidone) and ethylcellulose on alginate microspheres prepared by emulsification

Cited by 30 publications

References 19 publications

Alginate in Drug Delivery Systems

Alginate in Drug Delivery Systems

Magnetic Microspheres: A Novel Drug Delivery System

Magnetic Microspheres: A Novel Drug Delivery System

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