Effects of polycyclic aromatic hydrocarbons and abiotic stressors on Fundulus grandis cardiac transcriptomics

Allmon, Elizabeth; Serafin, Jennifer; Chen, Shuai; Rodgers, Maria L.; Griffitt, Robert J.; Bosker, Thijs; Guise, Sylvain De; Sepúlveda, Marı́a S.

doi:10.1016/j.scitotenv.2020.142156

Cited by 6 publications

(3 citation statements)

References 71 publications

(111 reference statements)

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“…The pattern of GST levels occurred regardless of the tissue-concentration of PAHs, which possibly indicated that the detoxification activity responded to the compounding of low salinity on PAH burden rather than the increasing PAH accumulation at lower salinities. Such apparent changes in toxicity due to reduced salinity were not observed in a number of studies that varied abiotic factors during the exposure of fish to a water attenuated fraction of weathered oil (Serafin et al, 2019;Simning et al, 2019;Allmon et al, 2021). Additionally, Schrandt et al (2018) found that oil (MC252)-exposed juvenile C. virginica showed a clear interaction between oil exposure and salinity on the survivorship and shell growth.…”

Section: Salinity and Pahsmentioning

confidence: 95%

Impact of Polycyclic Aromatic Hydrocarbon Accumulation on Oyster Health

Gan

Martin

2021

Front. Physiol.

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In the past decade, the Deepwater Horizon oil spill triggered a spike in investigatory effort on the effects of crude oil chemicals, most notably polycyclic aromatic hydrocarbons (PAHs), on marine organisms and ecosystems. Oysters, susceptible to both waterborne and sediment-bound contaminants due to their filter-feeding and sessile nature, have become of great interest among scientists as both a bioindicator and model organism for research on environmental stressors. It has been shown in many parts of the world that PAHs readily bioaccumulate in the soft tissues of oysters. Subsequent experiments have highlighted the negative effects associated with exposure to PAHs including the upregulation of antioxidant and detoxifying gene transcripts and enzyme activities such as Superoxide dismutase, Cytochrome P450 enzymes, and Glutathione S-transferase, reduction in DNA integrity, increased infection prevalence, and reduced and abnormal larval growth. Much of these effects could be attributed to either oxidative damage, or a reallocation of energy away from critical biological processes such as reproduction and calcification toward health maintenance. Additional abiotic stressors including increased temperature, reduced salinity, and reduced pH may change how the oyster responds to environmental contaminants and may compound the negative effects of PAH exposure. The negative effects of acidification and longer-term salinity changes appear to add onto that of PAH toxicity, while shorter-term salinity changes may induce mechanisms that reduce PAH exposure. Elevated temperatures, on the other hand, cause such large physiological effects on their own that additional PAH exposure either fails to cause any significant effects or that the effects have little discernable pattern. In this review, the oyster is recognized as a model organism for the study of negative anthropogenic impacts on the environment, and the effects of various environmental stressors on the oyster model are compared, while synergistic effects of these stressors to PAH exposure are considered. Lastly, the understudied effects of PAH photo-toxicity on oysters reveals drastic increases to the toxicity of PAHs via photooxidation and the formation of quinones. The consequences of the interaction between local and global environmental stressors thus provide a glimpse into the differential response to anthropogenic impacts across regions of the world.

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Section: Salinity and Pahsmentioning

confidence: 95%

Impact of Polycyclic Aromatic Hydrocarbon Accumulation on Oyster Health

Gan

Martin

2021

Front. Physiol.

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“…An important body of the literature describes the mechanisms that, in aquatic species, sustain cardiac adaptation to environmental challenges, with attention not only to the upper and lower limits of this adaptation, but also to the molecular pathways that are recruited during the exposure to multiple challenges, an event that is becoming more and more frequent in damaged natural environments. A recent example is the cardiac transcriptomic response described in Fundulus grandis developing larvae to four combined stressors (O 2 availability, temperature, salinity, and polycyclic aromatic hydrocarbons) [ 7 ]. It was found that each single stress, administered alone, affects the heart in terms of beat-to-beat hemodynamic and development.…”

Section: Introductionmentioning

confidence: 99%

“…At the same time, stress combination potentiates the effects on the heart, either positively or negatively, by affecting canonical pathways involved in heart contractility, vasomotility, and cardiomyocyte proliferation. These pathways include the cardiac nitrergic system [ 7 ]. As demonstrated by many papers, in the heart, this system is at the crossroads of many stress-sensitive circuits [ 8 , 9 , 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Hypoxic and Thermal Stress: Many Ways Leading to the NOS/NO System in the Fish Heart

et al. 2021

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Teleost fish are often regarded with interest for the remarkable ability of several species to tolerate even dramatic stresses, either internal or external, as in the case of fluctuations in O2 availability and temperature regimes. These events are naturally experienced by many fish species under different time scales, but they are now exacerbated by growing environmental changes. This further challenges the intrinsic ability of animals to cope with stress. The heart is crucial for the stress response, since a proper modulation of the cardiac function allows blood perfusion to the whole organism, particularly to respiratory organs and the brain. In cardiac cells, key signalling pathways are activated for maintaining molecular equilibrium, thus improving stress tolerance. In fish, the nitric oxide synthase (NOS)/nitric oxide (NO) system is fundamental for modulating the basal cardiac performance and is involved in the control of many adaptive responses to stress, including those related to variations in O2 and thermal regimes. In this review, we aim to illustrate, by integrating the classic and novel literature, the current knowledge on the NOS/NO system as a crucial component of the cardiac molecular mechanisms that sustain stress tolerance and adaptation, thus providing some species, such as tolerant cyprinids, with a high resistance to stress.

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