Effects of Polysaccharide Derived from Black Currant on Relieving Clinical Symptoms of Japanese Cedar Pollinosis: A Randomized Double-Blind, Placebo-Controlled Trial

Dejima, Kenji; Ohshima, Akihiro; Yanai, Takaaki; Yamamoto, Reiko; Takata, Ryoji; Yoshikawa, Toshikazu

doi:10.1271/bbb.70413

Cited by 9 publications

(7 citation statements)

References 12 publications

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“…These properties are mainly due to the anthocyanins in black currant. In previous studies, we found immunostimulating effects of a polysaccharide, which we named cassis polysaccharide (CAPS), derived from black currant [5,6,7] and we identified its antitumor activity and ability to induce tumor necrosis factor-α (TNF-α) production in a mouse study [5, 6]. We also found that CAPS has an effect on macrophage activation in in vitro experiments [5, 6].…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide from black currant (<i>Ribes nigrum</i> L.) stimulates dendritic cells through TLR4 signaling

Ashigai

Komano

Wang

et al. 2017

Bioscience of Microbiota, Food and Health

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Black currant (Ribes nigrum) has various beneficial properties for human health. In particular, polysaccharide from black currant was found to be an immunostimulating food ingredient and was reported to have antitumor activity in a mouse model. We named it cassis polysaccharide (CAPS). In a previous study, CAPS administration caused tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) production in vitro and in vivo, but the immunological mechanism of CAPS was not demonstrated. In this study, we revealed the CAPS immunostimulating mechanism in vitro. First, we found that CAPS activated dendritic cells (DCs). Second, we investigated whether it depends on Toll-like receptor 4 (TLR4) and myeloid differentiation primary response (Myd). We concluded that CAPS stimulates DCs through Myd88 depending TLR4 signaling and activates Th1-type cytokine release.

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Section: Introductionmentioning

confidence: 99%

Polysaccharide from black currant (<i>Ribes nigrum</i> L.) stimulates dendritic cells through TLR4 signaling

Ashigai

Komano

Wang

et al. 2017

Bioscience of Microbiota, Food and Health

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“…Recently, the health beneˆts of natural products that can exhibit preventative eŠects against multiple human diseases have attracted a lot of attention given the background of an aging society, increasing environmental pollution and a growing awareness of factors related to quality of life. Blackcurrant is one of the fruits reported as having some health-promoting properties (20)(21)(22). In the present study, we used the yeast LOH assay to observe the antimutagenic eŠect of extract from blackcurrant.…”

Section: Discussionmentioning

confidence: 99%

The Antimutagenic Activities of Blackcurrant Extract: Evaluation Using Saccharomyces cerevisiae LOH System

Yamamoto

Kawaguchi

Nakashima

et al. 2012

Genes and Environment

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We investigated the antimutagenic activity of extract from mature and premature blackcurrant using the yeast loss of heterozygosity (LOH) system. Blackcurrant is a classical fruit that has long been used to make juice, jam, liqueur and sometimes medicines in Europe. Recently, its beneˆcial health eŠects, including anticarcinogenic and antioxidative activities, have been reported and associated with the functions of anthocyanins. However, it remains unclear how blackcurrant exhibits an anticarcinogenic eŠect. In this study, we demonstrated the evaluation of the antimutagenic activity of blackcurrant extract (BCE) using the yeast LOH system. Induction of mutations by several mutagens, namely, H 2 O 2 , MMS and UV, was sig-niˆcantly suppressed by the combined treatment of the two types of BCE. In conclusion, ourˆndings clearly support the antimutagenic potential of blackcurrant, not only the mature fruit but also the premature fruit, as a useful food supplement.

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“…Ginseng extracts have been shown to exhibit anti-allergic effects originating from a potent cell membrane-stabilizing activity [20,45]. Blackcurrant (R. nigrum L.) is used for the control of allergic symptoms [19,21].…”

Section: Discussionmentioning

confidence: 99%

“…Olea europea extract is obtained from olive leaves and does not include any allergenic protein typical of olive pollen. The anti-allergic and anti-inflammatory properties of each of the extracts present in the mixture are reported in the literature [17][18][19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

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Effects of a new nutraceutical ingredient on allergen-induced sulphidoleukotrienes production and CD63 expression in allergic subjects

Caruso

Frasca

Giuseppe

et al. 2008

International Immunopharmacology

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Effects of Polysaccharide Derived from Black Currant on Relieving Clinical Symptoms of Japanese Cedar Pollinosis: A Randomized Double-Blind, Placebo-Controlled Trial

Cited by 9 publications

References 12 publications

Polysaccharide from black currant (<i>Ribes nigrum</i> L.) stimulates dendritic cells through TLR4 signaling

Polysaccharide from black currant (<i>Ribes nigrum</i> L.) stimulates dendritic cells through TLR4 signaling

The Antimutagenic Activities of Blackcurrant Extract: Evaluation Using Saccharomyces cerevisiae LOH System

Effects of a new nutraceutical ingredient on allergen-induced sulphidoleukotrienes production and CD63 expression in allergic subjects

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