Effects of polysaccharide from Portulaca oleracea L. on voltage-gated Na+ channel of INS-1 cells

Hu, Qingjuan; Li, Yuping; Liu, Chao; Huang, Liping; Zeng, Lvming; Wang, Songhua; Song, Hao; Peng, Hailong; Huang, Jianhua; Chen, Chong; Yao, Lihua

doi:10.1016/j.biopha.2018.02.136

Cited by 5 publications

(4 citation statements)

References 34 publications

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“…As a common homology of medicine and food, it also has a variety of indications (Iranshahy et al, 2017). Purslane is rich in bioactive substances, multiple flavonoids, alkaloids, polysaccharides, fatty acids, terpenoids, steroids, and proteins and is high in vitamins and minerals (Hu et al, 2018;Miao et al, 2019). Polysaccharides are the main active ingredients that have been widely studied.…”

Section: Introductionmentioning

confidence: 99%

“…Results of the structural analysis show that glucose and galactose are the main monosaccharide molecules of Portulaca oleracea polysaccharide (POP). Research has demonstrated that POP exhibits antitumor and antimicrobial activities, improves diabetes, and promotes oxidation resistance (Dong et al, 2010;Hu et al, 2018). Our recently published study revealed that POP significantly improved the gut microbiota composition of weaned rats and promoted colonization probiotics such as Lactobacilli and Bifidobacteria, thus affecting the metabolic function of rats (Huang et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Portulaca oleracea Polysaccharides Modulate Intestinal Microflora in Aged Rats in vitro

Zhou

et al. 2022

Front. Microbiol.

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To explore the effect of Portulaca oleracea polysaccharides (POP) in regulating intestinal microflora in aged rats in vitro, its intestinal microbial composition was analyzed by 16 S rDNA high-throughput sequencing, and the level of short-chain fatty acids in fermentation broth was determined by LC-MS. POP significantly upregulated the relative abundance of Lactobacillus, Eggerthella, and Paraprevotella and significantly downregulated Escherichia_Shigella, Bacteroides, and Eubacterium nodatum groups. The pH value and ammonia nitrogen level decreased significantly in the POP-treated group, resulting in a more short-chain fatty acid consumption which changed the acid–base environment of the fermentation broth. In conclusion, POP is beneficial to aged rats because it can regulate intestinal flora, promote the growth of probiotics, and inhibit the reproduction of pathogenic bacteria.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Portulaca oleracea Polysaccharides Modulate Intestinal Microflora in Aged Rats in vitro

Zhou

et al. 2022

Front. Microbiol.

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“…Through literature review, it was found that polysaccharide is an important active ingredient of fungal traditional Chinese medicine, such as Ganoderma lucidum, Auricularia auricular-judae and Portulaca oleracea, etc. [23][24][25]. In terms of the research progress of Ganoderma lucidum polysaccharide, the chemical structure, biological activity and corresponding structure-activity relationship have been deciphered [26,27].…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review on the Research Progress on Polysaccharides from Fungal Traditional Chinese Medicine

Bai,

Su,

Zhang

et al. 2023

Molecules

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Traditional Chinese medicine (TCM) is a class of natural drugs with multiple components and significant therapeutic effects through multiple targets. It also originates from a wide range of sources containing plants, animals and minerals, and among them, plant-based Chinese medicine also includes fungi. Fungal traditional Chinese medicine is a medicinal resource with a long history and widespread application in China. Accumulating evidence confirms that polysaccharide is the main pharmacodynamic material on which fungal TCM is based. The purpose of the current systematic review is to summarize the extraction, isolation, structural identification, biological functions, quality control and medicinal and edible applications of polysaccharides from fungal TCM in the past three years. This paper will supplement and deepen the understanding and application of polysaccharides from fungal TCM, and propose some valuable insights for further research and development of drugs and functional foods.

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“…the pro-inflammatory cytokine levels (IL-1β, IL-6, TNF-α);Up-regulate cytoplasmic NF-κB p65 and down-regulate the intranuclear NF-κB p65 Enhance glucose uptake by stimulating GLUT4 translocation to the plasma membrane through activating the PI3K and AMPK pathway Glucose uptake was increased 1.45-fold (treat with 50 µg/mL)[7] polysaccharide POPProtect INS-1 cells and enhance the insulin synthesis in INS-1 cells by partially inhibiting on I Na channelIncrease insulin contents by 165.22% ± 20.74% compared control (treat with 0.5 mg/ mL)[146] Polysaccharide POP Regulate insulin secretion in INS-1 cells through voltage-gated Na + channel POP at 0.05-1 mg/ml increased insulin secretion; 0.1 mg/ml POP downregulate the expression levels of Na V1.of circulating H1N1 and H3N2 and inhibit the binding of virus to cellsEC 50 = 220.1 µg/mL (A/WSN/1933 (H1N1)) EC 50 = 121.6 µg/mL (A/California/07/2009 (H1N1)) EC 50 = 112.4 µg/mL (A/Perth/16/2009 (H3N2)) EC 50 = 191.2 µg/mL (A/Brisbane/10the growth of Staphylococcus aureus, Escherichia coli, Bacillus subtilis, and Candida albicans Growth suppression zones (mm) are 20.0, 18.0, 21.0, 15.0, respectively [135] Ethyl acetate fraction Against dermatophytes of the genera Trichophyton SAFA (static antifungal activity) = 64 % for T. mentagrophytes EV861 [133] SAFA = 70 % for T…”

mentioning

confidence: 99%

Nutritional values, bioactive compounds and health benefits of purslane ( Portulaca oleracea L.): a comprehensive review

Li,

Xiao,

Yan

et al. 2024

Food Science and Human Wellness

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Portulaca oleracea L., commonly known as purslane, is a worldwide weed species belonging to the family Portulacaceae and has been known as "Global Panacea". As one of the most widely consumed green vegetable and medicinal plants around the world, it has recently been re-evaluated as a potential "new crop" due to the properties that differentiate it as one of the best vegetable sources of omega-3 fatty acid (α-linolenic acid), as well as a variety of nutrients and phytochemicals. Accordingly, emerging research has found that purslane exhibits health-promoting properties like anti-inflammatory, anti-hyperglycemic, antioxidant, neuroprotective, and immunomodulatory. These findings suggest that this species possesses a potential using as a dietary supplement beyond potherb and traditional medicine. This review systematically summarizes the up-to-date research carried out on purslane, which includes the nutritional compositions, bioactive compounds, and health benefits it exerts as well as limitations, challenges, and future directions of research. Finally, we hope that this review would provide purslane with a comprehensive reference and future scope as functional and health-promoting food for disease prevention and treatment.

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Effects of polysaccharide from Portulaca oleracea L. on voltage-gated Na+ channel of INS-1 cells

Cited by 5 publications

References 34 publications

Portulaca oleracea Polysaccharides Modulate Intestinal Microflora in Aged Rats in vitro

Portulaca oleracea Polysaccharides Modulate Intestinal Microflora in Aged Rats in vitro

A Systematic Review on the Research Progress on Polysaccharides from Fungal Traditional Chinese Medicine

Nutritional values, bioactive compounds and health benefits of purslane ( Portulaca oleracea L.): a comprehensive review

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