Effects of polysaccharides from &lt;i&gt;Cordyceps sinensis&lt;/i&gt; mycelium on physical fatigue in mice

Feng, Yan; Zhang, Yan; Wang, Beibei

doi:10.3329/bjp.v7i3.11727

Cited by 22 publications

(17 citation statements)

References 22 publications

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“…Recent studies have demonstrated the multiple pharmacological actions of CSP, including antitumor, antiinflammatory, antioxidant, antifatigue, hypoglycemic, hypolipidemic, liver protective effects and immunomodulatory properties (Kuo et al, 2007;Li & Li, 2009;Li et al, 2006;Wang et al, 2009;Zhong et al, 2009). In our previous studies, CSP has also been proven to have significant antifatigue effects in mice (Yan et al, 2012). However, the effects of CSP on exercise-induced oxidative stress are not clear.…”

Section: Introductionmentioning

confidence: 99%

“…The treated groups were received CSP (100, 200 and 400 mg/kg, ig) dissolved in 1.0 mL of drinking water, and the control group received drinking water (1.0 mL, ig) for 28 days. After 28 days, exhaustive swimming exercise was performed by our previously described method (Yan et al, 2012). In brief, the mice swam with tin wire of 7% body weight tied to their tails in an acrylic plastic tank (50 cm Â 50 cm Â 40 cm) filled with 30 cm depth of water maintained at 25 AE 1 C. The mice were assessed to be exhausted when they failed to rise to the surface of water to breathe within a 10-s period (Bing & Zhaobao, 2010;Cai et al, 2010;Tan et al, 2012).…”

Section: Exhaustive Swimming Exercisementioning

confidence: 99%

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Polysaccharides fromCordyceps sinensismycelium ameliorate exhaustive swimming exercise-induced oxidative stress

Feng

Wang

Yan³

2013

Pharmaceutical Biology

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Context: Cordyceps sinensis (Berk.) Sacc. (Clavicipitaceae) is a famous medicinal fungus (mushroom) in Chinese herbal medicine. Polysaccharides from Cordyceps sinensis (CSP) have been identified as active ingredients responsible for its biological activities. Although many pharmacological actions of CSP have received a great deal of attention, research in this area continues. Objective: The current study was designed to investigate the effects of CSP on exhaustive exercise-induced oxidative stress. Materials and methods: The mice were divided into four groups: control (C), low-dose CSP treated (LC), intermediate-dose CSP treated (IC) and high-dose CSP treated (HC). The treated groups received CSP (100, 200 and 400 mg/kg, ig), while the control group received drinking water for 28 days, followed by being forced to undergo exhaustive swimming exercise, and some biochemical parameters including superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), malondialdehyde (MDA) and 8-hydroxy-2 0 -deoxyguanosine (8-OHdG) were measured using detection kits according to the manufacturers' instructions. Results: Compared with the C group, exhaustive swimming time was significantly prolonged in the LC, IC and HC groups (p50.05); SOD activities in serum, liver and muscle were significantly higher in the IC and HC groups (p50.05); GPx activities in serum, liver and muscle were significantly higher in the LC, IC and HC groups (p50.05); CAT activities in serum, liver and muscle were significantly higher in the HC groups (p50.05); MDA and 8-OHdG levels in serum, liver and muscle were significantly lower in the LC, IC and HC groups (p50.05). Discussion and conclusion: The results obtained herein indicate that CSP could ameliorate exhaustive exercise-induced oxidative stress.

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Section: Introductionmentioning

confidence: 99%

Section: Exhaustive Swimming Exercisementioning

confidence: 99%

Polysaccharides fromCordyceps sinensismycelium ameliorate exhaustive swimming exercise-induced oxidative stress

Feng

Wang

Yan³

2013

Pharmaceutical Biology

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“…As aforementioned, IPSs and EPSs obtained from wild or cultured C. sinensis demonstrate immunoregulation, antitumour, antioxidation, and hypoglycemic effects, as well as other important bioactivities, including anti-fibrosis, anti-fatigue, kidney protection, increasing plasma testosterone levels, and radiation protection Wong, Wu, & Benzie, 2011;Yan, Zhang, & Wang, 2012;Yao et al, 2014;Zhang, Cheung, Al-Assaf, Phillips, & Phillips, 2012;Zhong et al, 2009).…”

Section: Other Bioactivitiesmentioning

confidence: 95%

Recent advances in Cordyceps sinensis polysaccharides: Mycelial fermentation, isolation, structure, and bioactivities: A review

Yan

Wang

2014

Journal of Functional Foods

212

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Polysaccharide Production Extraction Structural elucidation Bioactivity A B S T R A C T Cordyceps (Ophiocordyceps sinensis) sinensis, the Chinese caterpillar fungus, is a unique and precious medicinal fungus in traditional Chinese medicine which has been used as a prestigious tonic and therapeutic herb in China for centuries. Polysaccharides are bioactive constituents of C. sinensis, exhibiting several activities such as immunomodulation, antitumour, antioxidant and hypoglycaemic. As natural C. sinensis fruiting body-caterpillar complexes are very rare and expensive, the polysaccharides documented over the last 15-20 years from this fungal species were mostly extracted from cultivated fungal mycelia (intracellular polysaccharides) or from mycelial fermentation broth (exopolysaccharides).Extraction and purification of the polysaccharides is a tedious process involving numerous steps of liquid and solid phase separations. Nevertheless, a large number of polysaccharide structures have been purified and elucidated. However, relationships between the structures and activities of these polysaccharides are not well established. This review provides a comprehensive summary of the most recent developments in various aspects (i.e., production, extraction, structure, and bioactivity) of the intracellular and exopolysaccharides from mycelial fermentation of C. sinensis fungi. The contents and data will serve as useful references for further investigation, production and application of these polysaccharides in functional foods and therapeutic agents.

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“…Both IPS and EPS obtained from wild or cultured C. sinensis show immunomodulation, anti-tumor, anti-oxidant and hypoglycemic effects, as well as other important biological activities, including anti-fibrosis, anti-fatigue, kidney protection, increasing plasma testosterone levels, and radiation protection. 30,[69][70][71][72][73]111,113…”

Section: Cordyceps Sinensismentioning

confidence: 99%

The structures and biological functions of polysaccharides from traditional Chinese herbs

Zeng

Chen

et al. 2019

Progress in Molecular Biology and Translational Science

270

121

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Most of traditional Chinese medicine substances come from herbal plants. The medicinal quality of herbal plants varies with the locations of cultivation, the parts of the herb collected, the season of the herb collected, and the herb processing method. Polysaccharides are major components of the herb plants and their biosynthesis is partly controlled by the genes but mostly influenced by the availability of the nutrition and determined by the various environmental factors. In recent decades, polysaccharides isolated from different kinds of Chinese herbs have received much attention due to their important biological activities, such as anti-tumor, anti-oxidant, anti-diabetic, radiation protecting, antiviral, hypolipidemic, and immunomodulatory activities. Interestingly, different batches of the same herb can obtain different polysaccharide fractions with

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Effects of polysaccharides from <i>Cordyceps sinensis</i> mycelium on physical fatigue in mice

Cited by 22 publications

References 22 publications

Polysaccharides fromCordyceps sinensismycelium ameliorate exhaustive swimming exercise-induced oxidative stress

Polysaccharides fromCordyceps sinensismycelium ameliorate exhaustive swimming exercise-induced oxidative stress

Recent advances in Cordyceps sinensis polysaccharides: Mycelial fermentation, isolation, structure, and bioactivities: A review

The structures and biological functions of polysaccharides from traditional Chinese herbs

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