Effects of Polysaccharides from &lt;i&gt;Gynostemma Pentaphyllum&lt;/i&gt; (Thunb.), Makino on Physical Fatigue

Lin-Na, Shan; Yong-Xiu, Shi

doi:10.4314/ajtcam.v11i3.17

Cited by 14 publications

(10 citation statements)

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“…Polysaccharides are one of the most abundant components of G. pentaphyllum and represent a major group of biologically active constituents. G. pentaphyllum polysaccharides isolated with different extraction and purification methods have been shown to be structurally diverse biomacromolecules with various functions, including anti-inflammatory [ 18 ], antitumor [ 19 ], immunomodulatory [ 20 , 21 ], and antioxidant activities [ 22 ], antiexercise fatigue properties [ 23 , 24 ], hepatoprotective [ 25 ], and neuroprotective [ 26 ] activities and as a therapeutic agent for the treatment hyperlipidemia disorders [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Isolation, Structures, and Bioactivities of the Polysaccharides fromGynostemma pentaphyllum(Thunb.) Makino: A Review

Shen

Guo

2018

BioMed Research International

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Polysaccharides obtained from Gynostemma pentaphyllum (Thunb.) Makino have promising prospects in functional food and nutraceuticals due to its broad range of biological activities including antioxidant, immunomodulatory, antitumor, hepatoprotective, neuroprotective, and antifatigue activities. These beneficial biological activities are related to chemical composition and structure of the G. pentaphyllum polysaccharides. The molecular weight, monosaccharide composition, and chemical structures could be influenced by both different extraction/purification techniques employed to obtain polysaccharide enriched products. The purpose of this article is to review previous and current literature regarding the extraction, purification, structural characterization, and biological activity of G. pentaphyllum polysaccharides. This review provides a useful bibliography for the further investigation, production, and application of G. pentaphyllum polysaccharides as functional foods and nutraceuticals.

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Section: Introductionmentioning

confidence: 99%

Isolation, Structures, and Bioactivities of the Polysaccharides fromGynostemma pentaphyllum(Thunb.) Makino: A Review

Shen

Guo

2018

BioMed Research International

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“…Therefore, the blood TG and glucose or glycogen levels in the muscle and liver are important indices of maintenance performance, which can delay physical fatigue [ 41 ]. These effects of G. pentaphyllum on enhanced exercise performance have been reported with polysaccharides and gypenosides [ 3 4 24 ]. Wang et al [ 3 ] reported that G. pentaphyllum polysaccharide supplementation could increase the swimming exhaustion time and liver glycogen content and reduce oxidative stress.…”

Section: Discussionmentioning

confidence: 67%

“…Makino is an herbaceous vine plant of the family Cucurbitaceae , whose leaves are used for traditional tea or oriental herb medicine in Asia [ 3 ]. G. pentaphyllum has been prescribed traditionally for clearing heat, detoxification, dry cough, and chronic bronchitis [ 4 ]. Several studies have reported that G. pentaphyllum has important biological activities, including anti-oxidant [ 5 ], anti-inflammatory [ 6 7 8 ], hypoglycemic [ 9 ], hypolipidemic [ 10 11 12 ], anti-obesity [ 13 ], anti-diabetic [ 14 ], neuroprotective [ 15 ], and anti-cancer properties [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…The no observed adverse effect level of the G. pentaphyllum oral extract in rats was reported to be 750 mg/kg [ 21 ]. Recent studies have shown that gypenosides and polysaccharides from G. pentaphyllum extend the swimming exhaustion time and increase the hepatic and muscle glycogen concentrations in mice [ 3 4 22 23 24 ]. Although the beneficial effects of G. pentaphyllum have been proven, the possible energy metabolism and associated molecular mechanisms behind the ability of the G. pentaphyllum extract (GPE) to increase the exercise capacity of mice on treadmill exercise is unknown.…”

Section: Introductionmentioning

confidence: 99%

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Gynostemma pentaphyllum extract and its active component gypenoside L improve the exercise performance of treadmill-trained mice

Kim¹,

Jung

Jeon

et al. 2022

Nutr Res Pract

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BACKGROUND/OBJECTIVES The effectiveness of natural compounds in improving athletic ability has attracted attention in both sports and research. Gynostemma pentaphyllum (Thunb.) leaves are used to make traditional herbal medicines in Asia. The active components of G. pentaphyllum , dammarane saponins, or gypenosides, possess a range of biological activities. On the other hand, the anti-fatigue effects from G. pentaphyllum extract (GPE) and its effective compound, gypenoside L (GL), remain to be determined. MATERIALS/METHODS This study examined the effects of GPE on fatigue and exercise performance in ICR mice. GPE was administered orally to mice for 6 weeks, with or without treadmill training. The biochemical analysis in serum, glycogen content, mRNA, and protein expressions of the liver and muscle were analyzed. RESULTS The ExGPE (exercise with 300 mg/kg body weight/day of GPE) mice decreased the fat mass percentage significantly compared to the ExC mice, while the ExGPE showed the greatest lean mass percentage compared to the ExC group. The administration of GPE improved the exercise endurance and capacity in treadmill-trained mice, increased glucose and triglycerides, and decreased the serum creatine kinase and lactate levels after intensive exercise. The muscle glycogen levels were higher in the ExGPE group than the ExC group. GPE increased the level of mitochondrial biogenesis by enhancing the phosphorylation of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) protein and the mRNA expression of nuclear respiratory factor 1, mitochondrial DNA, peroxisome proliferator-activated receptor-δ, superoxide dismutase 2, and by decreasing the lactate dehydrogenase B level in the soleus muscle (SOL). GPE also improved PGC-1α activation in the SOL significantly through AMPK/p38 phosphorylation. CONCLUSIONS These results showed that GPE supplementation enhances exercise performance and has anti-fatigue activity. In addition, the underlying molecular mechanism was elucidated. Therefore, GPE is a promising candidate for developing functional foods and enhancing the exercise capacity and anti-fatigue activity.

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“…Endurance-swimming time, forelimb-grip strength, and changes in biochemical marker levels were studied and a histological analysis of muscle and other tissues was performed to assess the fatigue in animal models [ 24 , 25 ]. Endurance-swimming time in a forced-swimming test, forelimb-grip test, and rotary rod test have been widely used in animal models for evaluating the anti-fatigue efficacy of drugs or natural compounds [ 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Fatigue and Exercise Performance Improvement Effect of Glossogyne tenuifolia Extract in Mice

et al. 2022

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Glossogyne tenuifolia (GT) is a native perennial plant growing across the coastline areas in Taiwan. The current study aimed to examine the efficacy of GT extract in ameliorating physical fatigue during exercise and increasing exercise performance. Fifty male Institute of Cancer Research (ICR) mice were randomly segregated into five groups (n = 10) to GT extract orally for 4 weeks, at different concentrations (50, 100, 250, and 500 mg/kg BW/day): LGT 1X, MGT 2X, HGT 5X, and HGT 10X groups. Forelimb grip strength, endurance swimming time, serum biochemical marker levels, blood lipid profile and histological analysis of various organs were performed to assess the anti-fatigue effect and exercise performance of GT extract. The forelimb-grips strength and endurance-swimming time of GT-administered mice were increased significantly in a dose-dependent manner when compared to the control. Serum glucose, creatine kinase, and lactate levels were increased significantly in the HGT 10X group. Liver marker serum glutamic-oxaloacetic transaminase (GOT) was increased in the HGT 5X and HGT 10X groups, whereas Serum Glutamic Pyruvic Transaminase (GPT) was not altered. Renal markers, creatinine and uric acid levels, were not altered. Muscle and hepatic glycogen levels, which are essential for energy sources during exercise, were also significantly increased in a dose-dependent manner in all GT extract groups. No visible histological aberrations were observed in the vital organs after GT extract administration. The supplementation with GT extract could have beneficial effects on exercise performance and anti-fatigue function without toxicity at a higher dose.

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Effects of Polysaccharides from <i>Gynostemma Pentaphyllum</i> (Thunb.), Makino on Physical Fatigue

Cited by 14 publications

References 30 publications

Isolation, Structures, and Bioactivities of the Polysaccharides fromGynostemma pentaphyllum(Thunb.) Makino: A Review

Isolation, Structures, and Bioactivities of the Polysaccharides fromGynostemma pentaphyllum(Thunb.) Makino: A Review

Gynostemma pentaphyllum extract and its active component gypenoside L improve the exercise performance of treadmill-trained mice

Anti-Fatigue and Exercise Performance Improvement Effect of Glossogyne tenuifolia Extract in Mice

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