Effects of polystyrene microparticles on inflammation, antioxidant enzyme activities, and related gene expression in Nile tilapia (Oreochromis niloticus)

Ahmadifar, Ehsan; Kalhor, Naser; Dawood, Mahmoud A.O.; Ahmadifar, Mehdi; Moghadam, Mohsen Shahriari; Abarghouei, Safoura; Hedayati, Aliakbar

doi:10.1007/s11356-020-11731-x

Cited by 27 publications

(19 citation statements)

References 36 publications

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“…Nile tilapia were exposed to 350 nm and 9 μm PS-MPs for 28 days. The expression of the IFN-γ gene was upregulated in the fish exposed to 350 nm and 9 μm, and the expressions of IL8, IL-1β, and TNF-α genes were upregulated in the group of fish exposed to 9 μm, compared with the control [ 97 ].…”

Section: Potential Mechanisms Of Mps/nps Toxicity On the Livermentioning

confidence: 99%

Nanoplastics and Microplastics May Be Damaging Our Livers

Yin

Qian

et al. 2022

Toxics

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Plastics in the environment can be degraded and even broken into pieces under the action of natural factors, and the degraded products with a particle size of less than 5 mm are called microplastics (MPs). MPs exist in a variety of environmental media that come into contact with the human body. It can enter the body through environmental media and food chains. At present, there are many studies investigating the damage of MPs to marine organisms and mammals. The liver is the largest metabolizing organ and plays an important role in the metabolism of MPs in the body. However, there is no available systematic review on the toxic effects of MPs on the liver. This paper summarizes the adverse effects and mechanisms of MPs on the liver, by searching the literature and highlighting the studies that have been published to date, and provides a scenario for the liver toxicity caused by MPs.

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Section: Potential Mechanisms Of Mps/nps Toxicity On the Livermentioning

confidence: 99%

Nanoplastics and Microplastics May Be Damaging Our Livers

Yin

Qian

et al. 2022

Toxics

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“…Aquatic organisms may be exposed throughout their life to various toxicants and environmental pollutants, which may consequently affect their health, induce serious toxicological signs, and result in heavy mortalities [ 1 , 2 ]. From these pollutants, sulphates are naturally occurring in the aquatic environments following plant decomposition, atmospheric deposition, and human activities, such as mining [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies reported that sodium sulphate (SS) induces toxic effects in exposed fathead minnows ( Pimephales promelas ) [ 4 ] and Nile tilapia ( Oreochromis niloticus ) [ 5 ]. The exposure of fish to environmental pollutants will induce oxidative stress because of the overproduction of reactive oxygen species (ROS), which will subsequently induce tissue damage and death [ 2 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Spirulina platensis Alleviated the Oxidative Damage in the Gills, Liver, and Kidney Organs of Nile Tilapia Intoxicated with Sodium Sulphate

Awed

Sadek

Soliman

et al. 2020

Animals

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The current study aimed at assessing the recuperative roles of dietary Spirulina platensis on the antioxidation capacity of Nile tilapia (Oreochromis niloticus) exposed to sodium sulphate for eight weeks. In brief, fish were allocated into four groups with three triplicates per group, where a group fed on a commercial basal diet served as control, a group was intoxicated with sodium sulphate (SS) 5.8 mg/L, another group was fed a diet supplemented with 1% S. platensis (SP), and the last group was fed 1% SP and concomitantly intoxicated with 5.8 mg/L sodium sulphate (SP/SS). Tissue antioxidative indices of each fish were measured as follows: glutathione peroxidase (GSH-Px) activity in muscles, catalase (CAT) and superoxide dismutase (SOD) activities in gills, and total antioxidant capacity (T-AOC) in the liver and kidney. Moreover, the expression of hepatic SOD, GSH-Px, and glutathione-S-transferase (GST) genes was also determined. It was found that tissue CAT, SOD, and GSH-Px activities as well as the T-AOC levels were significantly decreased in the SS group (p < 0.05). Moreover, there was a significant downregulation of hepatic SOD, GSH-Px, and GST genes in SS-exposed fish (p < 0.05). Interestingly, simultaneous dietary supplementation with SP provided a marked attenuation of the tissue antioxidative parameters when compared with the SS and control groups. To conclude, the present study exemplifies that dietary SP supplementation could be a beneficial abrogation of SS-induced tissue oxidative stress in the exposed fish.

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“…Yu et al, 2018). Increased GPX activity was reported in studies on Nile tilapia (Oreochromis niloticus) exposed to a dose of 5 μg L À1 PS-MPs (Ahmadifar et al, 2021) and on green discus (Symphysodon aequifasciatus) exposed to 50 μg L À1 of PS-MPs (Wen et al, 2018).…”

Section: Discussionmentioning

confidence: 80%

“…Similar results were reported in zebrafish, Eriocheir sinensis , and Macrobrachium nipponense juveniles, indicating the activation of the oxidative defense system (Li et al, 2020; Lu et al, 2016; Yu et al, 2018). Increased GPX activity was reported in studies on Nile tilapia ( Oreochromis niloticus ) exposed to a dose of 5 μg L −1 PS‐MPs (Ahmadifar et al, 2021) and on green discus ( Symphysodon aequifasciatus ) exposed to 50 μg L −1 of PS‐MPs (Wen et al, 2018).…”

Section: Discussionmentioning

confidence: 86%

Assessing the impact of dietary polystyrene nanoplastics on growth performance, immunological parameters, and antioxidant defense in zebrafish (Danio rerio)

Ahmadifar,

Shohreh,

Kalhor

et al. 2024

J World Aquaculture Soc

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This trial was performed in order to investigate the response of zebrafish (Danio rerio) to dietary exposure to polystyrene nanoplastics (PS‐NPs) under laboratory conditions on fish growth and health. Healthy zebrafish (n=240) were divided into 12 tanks and fed with diets including 0 (T0), 100 (T1), 500 (T2), and 1000 (T3) mg kg−1 synthesized polystyrenes nanoplastics (PS‐NPs) for 30 days. At the end of trial, fish fed the PS‐NPs supplementation showed weight gain percentages of 79.45%, 70.35%, and 61.88% for T1, T2, and T3 groups, respectively, compared with 87.39% in the control fish. The SOD, GPX and MDA activities and cortisol levels increased by 47%, 32% and 35% and 46%, respectively, especially at high‐dose administration (p < 0.05). The expression of GPX (T2‐81% and T3‐82%) and SOD (T2‐101% and T3‐187%) were remarkably upregulated in T2 and T3 groups. Moreover, the relative gene expression of HSP70, interleukin‐1 (IL1), Interferon γ (IFN‐γ) and tumor necrosis factor‐α (TNF‐α) increased by 178%, 202%, 154% and 307%, respectively, especially at high‐dose administration (p < 0.05). The results of the present study demonstrated that exposure to PS‐NPs especially at high concentrations (500 and 1000 mg kg−1 of diet) negatively influenced growth, health status‐, antioxidant‐, and immunity‐related gene expression responses of zebrafish.

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Effects of polystyrene microparticles on inflammation, antioxidant enzyme activities, and related gene expression in Nile tilapia (Oreochromis niloticus)

Cited by 27 publications

References 36 publications

Nanoplastics and Microplastics May Be Damaging Our Livers

Nanoplastics and Microplastics May Be Damaging Our Livers

Spirulina platensis Alleviated the Oxidative Damage in the Gills, Liver, and Kidney Organs of Nile Tilapia Intoxicated with Sodium Sulphate

Assessing the impact of dietary polystyrene nanoplastics on growth performance, immunological parameters, and antioxidant defense in zebrafish (Danio rerio)

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