Effects of Pomiferin Premedication on the Antioxidant Status of Rats with Ischemia-Reperfused Kidney

Janoštíková, Eva; Bartošíková, Lenka; Nečas, Jiří; Juřica, Jan; Florian, Tomáš; Bartošík, Tomáš; Klusáková, Jarmila; Suchý, Václav; Lišková, Margita; Frydrych, Marek

doi:10.2754/avb200574040557

Cited by 5 publications

(6 citation statements)

References 11 publications

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“…Lycopene has been known to be an effective antioxidant [30] as well as an anti-proliferative compound against several cancers [31]. Isopomiferin which is a derivative of plant-based compound pomiferin has been known to exhibit anti-microbial properties, anti-inflammatory agent, effective agent against diabetes and a potent antioxidant (Table 1) [32,33]. Density functional theory is a computer-based approach with procuring immense popularity in the field of in silico analysis.…”

Section: Fig 1 Flowchart Of Methodologymentioning

confidence: 99%

Insights into the inhibitory potential of selective phytochemicals against Mpro of 2019-nCoV: a computer-aided study

2020

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At the end of December 2019, a novel strain of coronavirus, given the name of 2019-nCoV, emerged for exhibiting symptoms of severe acute respiratory syndrome. The virus is spreading rapidly in China and around the globe, affecting thousands of people leading to a pandemic. To control the mortality rate associated with the 2019-nCoV, prompt steps are needed. Until now there is no effective treatment or drug present to control its life-threatening effects in the humans. The scientist is struggling to find new inhibitors of this deadly virus. In this study, to identify the effective inhibitor candidates against the main protease (Mpro) of 2019-nCoV, computational approaches were adopted. Phytochemicals having immense medicinal properties as ligands were docked against the Mpro of 2019-nCoV to study their binding properties. ADMET and DFT analyses were also further carried out to analyze the potential of these phytochemicals as an effective inhibitor against Mpro of 2019-nCoV.

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Section: Fig 1 Flowchart Of Methodologymentioning

confidence: 99%

Insights into the inhibitory potential of selective phytochemicals against Mpro of 2019-nCoV: a computer-aided study

2020

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“…An anti-inflammatory potential was also ascribed to pomiferin [27,32]. also in vivo animal models [25,26]. On the other hand, it showed also a mild pro-oxidant effect in cell-based models [27].…”

Section: Introductionmentioning

confidence: 92%

Copper(II) Complexes Containing Natural Flavonoid Pomiferin Show Considerable In Vitro Cytotoxicity and Anti-inflammatory Effects

Vančo

Trávníček

Hošek

et al. 2021

IJMS

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A series of new heteroleptic copper(II) complexes of the composition [Cu(L)(bpy)]NO3·2MeOH (1), [Cu(L)(dimebpy)]NO3·2H2O (2), [Cu(L)(phen)]NO3·2MeOH (3), [Cu(L)(bphen)]NO3·MeOH (4), [Cu(L)(dppz)]NO3·MeOH (5) was prepared, where HL = 3-(3,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-6-(3-methylbut-2-ene-1-yl)-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one, (pomiferin) and bpy = 2,2'-bipyridine, dimebpy = 4,4ʹ-dimethyl-2,2ʹ-bipyridine, phen = 1,10-phenanthroline, bphen = 4,7-diphenyl-1,10-phenanthroline, and dppz = dipyrido[3,2-a:2',3'-c]phenazine. The complexes were characterized using elemental analysis, infrared and UV/Vis spectroscopies, mass spectrometry, thermal analysis and conductivity measurements. The in vitro cytotoxicity, screened against eight human cancer cell lines (breast adenocarcinoma (MCF-7), osteosarcoma (HOS), lung adenocarcinoma (A549), prostate adenocarcinoma (PC-3), ovarian carcinoma (A2780), cisplatin-resistant ovarian carcinoma (A2780R), colorectal adenocarcinoma (Caco-2) and monocytic leukemia (THP-1), revealed the complexes as effective antiproliferative agents, with the IC50 values of 2.2–13.0 μM for the best performing complexes 3 and 5. All the complexes 1–5 showed the best activity against the A2780R cells (IC50 = 2.2–6.6 μM), and moreover, the complexes demonstrated relatively low toxicity on healthy human hepatocytes, with IC50 > 100 μM. The complexes were evaluated by the Annexin V/propidium iodide apoptosis assay, induction of cell cycle modifications in A2780 cells, production of reactive oxygen species (ROS), perturbation of mitochondrial membrane potential, inhibition of apoptosis and inflammation-related signaling pathways (NF-κB/AP-1 activity, NF-κB translocation, TNF-α secretion), and tested for nuclease mimicking activity. The obtained results revealed the corresponding complexes to be effective antiproliferative and anti-inflammatory agents.

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“…Mouse hepatic microsomes were used to determine the EROD activity (7-ethoxyresorufin-O-deethylase) of osajin and pomiferin 19 . In vivo studies confirmed the scavenging potential of osajin and pomiferin too [20][21] . Among various reactive oxygen species (ROS) generated during pathological processes, which cause or accompany ischemia/reperfusion (I/R) injury, O -2• plays the key role.…”

Section: Introductionmentioning

confidence: 57%

Effects of Prenylated Isoflavones Osajin and Pomiferin in Premedication on Heart Ischemia-Reperfusion

Florian¹,

Nečas²,

Bartošíková³

et al. 2006

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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The present 15 days study was undertaken to evaluate the cardioprotective potential of the prenylated isoflavones osajin and pomiferin isolated from the infructences of Maclura pomifera, Moraceae, against ischemia-reperfusion induced injury in rat hearts as a model of antioxidant-based composite therapy. The study was performed on isolated, modified Langendorff-perfused rat hearts and the ischemia of heart was induced by stopping coronary flow for 30 min followed by 60 min of reperfusion (14 ml min -1 ). The Wistar rats were divided into four groups. The first treatment group received osajin (5 mg/kg/day in 0.5% Avicel); the second treatment group received pomiferin (5 mg/kg/day in 0.5% Avicel); the placebo group received only 0.5 Avicel; the last was an untreated control group. Biochemical indicator of oxidative damage-lipid peroxidation product malondialdehyde, antioxidant enzymes -superoxide dismutase, glutathione peroxidase, total antioxidant activity in serum and myocardium were evaluated. The effect of osajin and pomiferin on cardiac function, left ventricular end-diastolic pressure, left ventricular pressure and peak positive +dP/dt ischemia and reperfusion, also was examined.The results demonstrate that osajin and pomiferin attenuates the myocardial dysfunction provoked by ischemiareperfusion. This was confirmed by an increase in both antioxidant enzyme values and total antioxidant activity. The cardioprotection provided by osajin and pomiferin treatment results from the suppression of oxidative stress and this correlates with improved ventricular function.

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Effects of Pomiferin Premedication on the Antioxidant Status of Rats with Ischemia-Reperfused Kidney

Cited by 5 publications

References 11 publications

Insights into the inhibitory potential of selective phytochemicals against Mpro of 2019-nCoV: a computer-aided study

Insights into the inhibitory potential of selective phytochemicals against Mpro of 2019-nCoV: a computer-aided study

Copper(II) Complexes Containing Natural Flavonoid Pomiferin Show Considerable In Vitro Cytotoxicity and Anti-inflammatory Effects

Effects of Prenylated Isoflavones Osajin and Pomiferin in Premedication on Heart Ischemia-Reperfusion

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