Effects of Portulaca oleracea L. seeds in treatment of type-2 diabetes mellitus patients as adjunctive and alternative therapy

El-Sayed, Mohamed-I Kotb

doi:10.1016/j.jep.2011.06.020

Cited by 143 publications

(132 citation statements)

References 25 publications

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“…Simultaneously, the patients showed a significant increase in highdensity lipoprotein cholesterol (HDLC) and albumin, and a non-significant change in alkaline phosphatase (ALP). These results demonstrate that P. oleraceae seeds possess notable hypoglycemic, hypolipidemic, and insulin resistancereducing effects, possibly due to their high content of polyunsaturated fatty acids, flavonoids, and polysaccharides [58].…”

Section: Portulaca Oleraceamentioning

confidence: 67%

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Gushiken¹,

Beserra²,

Rozza³

et al. 2016

Rev Diabet Stud

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■ AbstractDiabetes mellitus is a chronic disease and a leading cause of death in western countries. Despite advancements in the clinical management of the disease, it is not possible to control the late complications of diabetes. The main characteristic feature of diabetes is hyperglycemia, which reflects the deterioration in the use of glucose due to a faulty or poor response to insulin secretion. Alloxan and streptozotocin (STZ) are the chemical tools that are most commonly used to study the disease in rodents. Many plant species have been used in ethnopharmacology or to treat experimentally symptoms of this disease. When evaluated pharmacologically, most of the plants employed as antidiabetic substances have been shown to exhibit hypoglycemic and antihyperglycemic activities, and to contain chemical constituents that may be used as new antidiabetic agents. There are many substances extracted from plants that offer antidiabetic potential, whereas others may result in hypoglycemia as a side effect due to their toxicity, particularly their hepatotoxicity. In this article we present an updated overview of the studies on extracts from medicinal plants, relating the mechanisms of action by which these substances act and the natural principles of antidiabetic activity.

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Section: Portulaca Oleraceamentioning

confidence: 67%

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Gushiken¹,

Beserra²,

Rozza³

et al. 2016

Rev Diabet Stud

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“…for a period of 30 d. Groups VIII-XII were the treatment groups, and received purslane extract dissolved in distilled water (intragastrically; daily) at doses of 0.005, 0.01, 0.05, 0.1, and 0.15 g/kg bw, with CCl 4 (0.5 ml/kg bw, 50% CCl 4 in olive oil; twice a week, i.p.) for 30 d. The dose of purslane ethanolic extract was selected based on previous published reports (Cheng-Jie et al, 2009;El-Sayed, 2011). At the end of the treatment period, the rats were anesthetized by ether inhalation 48 h after the administration of CCl 4 .…”

Section: Experimental Designmentioning

confidence: 99%

Hepatoprotective effects ofPortulaca oleraceaextract against CCl₄-induced damage in rats

Eidi

Mortazavi

Moghadam

et al. 2014

Pharmaceutical Biology

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Context: Purslane (Portulaca oleracea L., Portulacaceae) has been traditionally used in folk medicine to afford protection against liver injury, although its actual efficacy remains uncertain. Objective: To evaluate purslane as a hepatoprotective agent, we investigated the protective effect of its ethanol extract against carbon tetrachloride (CCl 4 )-induced hepatic toxicity in rats. Materials and methods: A total of 108 male Wistar rats were randomly divided into 12 groups. The first group was maintained as normal control, whereas CCl 4 (0.5 ml/kg bw, 50% CCl 4 in olive oil, i.p.), purslane extract (0.005, 0.01, 0.05, 0.1, and 0.15 g/kg bw, intragastrically), and purslane extract (five doses as above) along with CCl 4 were administered to the Groups II, III-VII, and VIII-XII, respectively. The rats were sacrificed on the 30th day, and blood was withdrawn by cardiac puncture. Liver damage was assessed by measuring hepatic marker enzymes (ALT, AST, ALP, GGT, and SOD) and histopathological observation. Results: Treatment with CCl 4 resulted in increased serum activities of marker enzymes with a concomitant decrease in SOD. Histological alterations were also observed in the liver tissue upon CCl 4 treatment. Administration of purslane extract (0.01, 0.05, 0.1, and 0.15 g/kg b.w.) significantly showed a marked tendency towards normalization of all measured biochemical parameters in CCl 4 -treated rats. Histopathological changes also paralleled the detected alteration in markers of liver function. Discussion and conclusion: These results demonstrate that purslane exerts protective effects against CCl 4 -induced damage in rat liver and supports a potential therapeutic use of purslane as an alternative for patients with liver diseases.

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“…oleracea has several therapeutic effects including diuretic, antiascorbic, antipyretic, antiinflammatory [5][6][7] . The plant is also used for treatment of type-2 diabetes mellitus patients [8] . Different pharmacologic effects of this plant are antiinflammatory, analgesic [6] , antioxidant [9][10][11] , potassium channel opener and blood pressure modifier [12] , as well as neuropharmacological [13,14] , wound healing [15] , antibacterial [16] and antipyretic effects [17] .…”

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confidence: 99%

Portulaca olerace Affects Muscarinic Receptors of Guinea Pig Tracheal Smooth Muscle

Hashemzehi¹,

Khazdair²

2016

pharmaceutical-sciences

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Hashemzehi, et al.: Effect of Portulaca oleracea on Musacrinic ReceptorsThe relaxant effect of Portulaca oleracea L. on tracheal smooth muscles has been shown. The effect of the plant on muscarinic receptors of tracheal smooth muscles as one possible mechanism responsible for its relaxant effect was examined. Concentration response curves to methacholine were performed in the presence of three concentrations of aqueous-ethanol extract from aerial part of the plant (0.25, 0.50 and 1.00 mg/ml), 10 nM atropine, and saline. The values of EC 50 (effective concentration causing 50% of maximum response) and CR-1 ((EC 50 of test solutions/EC 50 of saline)-1) were measured. The study was done using three designs as non-incubated (group 1), incubated tissues with propranolol and chlorpheniramine (group 2) and incubated tissues with propranolol (group 3). Concentration-response curves to methacholine were shifted to the right and EC50 methacholine were significantly higher in the presence of atropine, medium and highest extract concentrations in all groups and its low concentration in group 3 compared to saline. In addition, EC 50 methacholine in the presence of high extract concentration (27.00±2.12) in group 2 was greater than its low (10.33±1.54) and medium (16.83±2.52) concentrations (p<0.05). The values of the CR-1 obtained in the presence of all extract concentrations in all groups were lower than that of atropine (P<0.05 to P<0.001). An inhibitory effect for the extract of P. oleracea on muscarinic receptors of tracheal smooth muscles was shown and a histamine (H 1 ) receptor blockade was also suggested.Key words: Portulaca oleracea, muscarinic receptor, tracheal smooth muscle, inhibitory effect, aqueousethanol extract Portulaca oleracea L. is an annual succulent which may reach 15.75 inches in height with alternate leaves clustered at stem joints; the yellow flower plant grows in different areas of the world including north and northwest of Iran [1] . Main active constituents of P. oleracea are omega-3 fatty acid, α-linolenic acid and eicosa-pentaenoic acid. This plant also contains vitamins (mainly vitamins A, C and some vitamin B) [2,3] . The plant also contains organic acids such as citric, maleic, cyanuric, caffeic acid as well as flavonoids, coumarins, and glycosides [4] .P. oleracea has several therapeutic effects including diuretic, antiascorbic, antipyretic, antiinflammatory [5][6][7] . The plant is also used for treatment of type-2 diabetes mellitus patients [8] . Different pharmacologic effects of this plant are antiinflammatory, analgesic [6] , antioxidant [9][10][11] , potassium channel opener and blood pressure modifier [12] , as well as neuropharmacological [13,14] , wound healing [15] , antibacterial [16] and antipyretic effects [17] . The relaxant effect of this plant was studied on skeletal muscles [18] and smooth muscle of small intestine [19] . Our previous studies also showed relaxant effect of the plant on tracheal smooth muscle [20] and the possible mechanism of this effect for this plant [21]...

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Effects of Portulaca oleracea L. seeds in treatment of type-2 diabetes mellitus patients as adjunctive and alternative therapy

Cited by 143 publications

References 25 publications

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Hepatoprotective effects ofPortulaca oleraceaextract against CCl₄-induced damage in rats

Portulaca olerace Affects Muscarinic Receptors of Guinea Pig Tracheal Smooth Muscle

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Effects of Portulaca oleracea L. seeds in treatment of type-2 diabetes mellitus patients as adjunctive and alternative therapy

Cited by 143 publications

References 25 publications

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Hepatoprotective effects ofPortulaca oleraceaextract against CCl4-induced damage in rats

Portulaca olerace Affects Muscarinic Receptors of Guinea Pig Tracheal Smooth Muscle

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Hepatoprotective effects ofPortulaca oleraceaextract against CCl₄-induced damage in rats