Effects of Positive Iron Status at a Cellular Level

McCord, Joe M.

doi:10.1111/j.1753-4887.1996.tb03876.x

Cited by 133 publications

(51 citation statements)

References 37 publications

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“…Furthermore, the apparent decrease in glutathione detoxification system in the gill, the first point of contact with environmental xenobiotics indicates that this system is a sensitive biochemical indicator of environmental pollution [40] in Clarias gariepinus. Increase in the activity of catalase and superoxide dismutase is usually observed in the face of environment pollutants [36,41] since superoxide dismutase-catalase system represents the first line of defense against oxidative stress [41] . Oxidative stress is believed to occur when the normal balance of the oxidant-to-antioxidant ratio is disturbed.…”

Section: Resultsmentioning

confidence: 99%

Biochemical Markers of Oxidative Stress in Brain of Zebrafish Danio rerio Exposed to Different Heavy Metals Lead and Cobalt

Singh¹,

Ansari²

2017

IJLSSR

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ABSTRACT-Aquatic organisms have been considered to concentrate metals several times greater than environmental levels. Fishes have been used for many decades to evaluate the pollution status of water and thus considered as excellent biological indicator of heavy metals in aquatic environments. Heavy metals are natural tress components of the aquatic environment, but their levels have increased due to domestic, industrial, mining and agricultural activities. These heavy metals when accumulated in the fish tissues, they damage and weaken the mechanisms concerned leading to physiological, pathological and biochemical changes. The lead is non essential element while cobalt is an essential element for living organisms but its presence in fresh water in higher concentration are toxic to organism's brain, liver, ovary, kidney and gills of the fish. The present study was aimed to investigate the changes due to two heavy metals (lead & cobalt) on the activity of the antioxidant enzyme, Catalase (CAT), Reduced glutathione (GSH), and Lipid peroxidation (LPO) in the brain of Danio rerio during 5, 10, 15 and 20 days of exposure period. For this study adult fishes were exposed to four different concentrations viz., 20, 30, 40 and 50 mg/l of cobalt and 5, 9, 13, and 17 mg/l of lead.

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Section: Resultsmentioning

confidence: 99%

Biochemical Markers of Oxidative Stress in Brain of Zebrafish Danio rerio Exposed to Different Heavy Metals Lead and Cobalt

Singh¹,

Ansari²

2017

IJLSSR

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“…Recent reports indicate that cytotoxicity induced by LDL and VLDL can result from lipoprotein oxidation. Ultimately indicated by the relative amount of MDA equivalents or thiobarbituric acid-reacting substances (TBARS) residing on the lipoprotein [37].…”

Section: Discussionmentioning

confidence: 99%

Effect of Iron Supplementation on Plasma Lipid Levels in Pregnant Anemic Women

2016

IJSR

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“…The overall result is a redistribution of Fe from extracellular to intracellular compartments, thus rendering Fe less accessible to invading pathogenic bacteria (Squires, 2004;Kannon, 2006). Superoxide radicals (O 2-), produced by enhancement of mitochondrial cytochrome P450 by toxins or pro-oxidants, or NADPH oxidase by phagocytes (Vignais, 2002), play key roles in oxidative stress by releasing Fe 2+ from ferritin after donating an electron to Fe 3+ (McCord, 1996;Orino & Watanabe, 2008). Oxidative stress mediated by reactive oxygen species (ROS) is major factor which is directly linked to inflammatory, malignant, and metabolic diseases in domestic and farm animals (Orino & Watanabe, 2008).…”

Section: Functionsmentioning

confidence: 99%