Effects of potential detoxifying agents on growth performance and deoxynivalenol (DON) urinary balance characteristics of nursery pigs fed DON-contaminated wheat

Frobose, H.L.; Stephenson, E. W.; Tokach, M.D.; DeRouchey, J.M.; Woodworth, J. C.; Dritz, S.S.; Goodband, R.D.

doi:10.2527/jas2016.0664

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…In high-DON diets, the biological mechanism of SMB is suggested to be the chemical alteration of DON to a nontoxic DON-sulfonate adduct form ( Frobose et al, 2015 , 2017 ). However, in low-DON diets the biological mechanism of SMB is unclear.…”

Section: Discussionmentioning

confidence: 99%

Effects of sodium metabisulfite additives on nursery pig growth

Shawk

Dritz

Goodband

et al. 2018

Translational Animal Science

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Sodium metabisulfite (SMB)-based feed additive efficacy was evaluated in three nursery pig growth experiments where pigs were fed diets containing low deoxynivalenol (<1.5 mg/kg; DON) concentrations. Pigs were weaned at approximately 22 d of age and randomly allotted to pens with one pen of 27 gilts and one pen of 27 barrows per feeder; thus, feeder was the experimental unit. In experiment 1, a total of 2,268 pigs were used in a 35-d trial with 21 feeders per treatment. Experimental treatments included a control diet or the control with 0.50% SMB-based Product 1 (Defusion; Provimi, Brookville, OH) fed in phase 1 and 0.25% fed in phases 2 and 3, then all pigs were fed a control diet for the last week of the study. Pigs fed Product 1 had greater (P < 0.05) ADG, ADFI, and G:F compared with pigs fed the control diet from days 0 to 28. However, from days 28 to 35, the opposite response was observed with pigs fed the control diet having greater ADG and G:F than pigs previously fed Product 1. Despite this response, pigs fed Product 1 were heavier (P < 0.05) on day 35 than control-fed pigs. In experiment 2, a total of 4,320 pigs were used in a 42-d trial. Pigs were fed a control diet or diets with SMB-based either Product 1 or Product 2 (NutriQuest, Mason City, IA) at different concentrations and durations. Among the various treatments, Product 1 or Product 2 concentrations ranged from 0.50% initially to 0.25%, 0.15%, or none the last week of the study. Overall, pigs fed either of the additives at the highest concentrations and for the longest period of time had greater (P < 0.05) ADG and ADFI compared with pigs fed the control diet, with those fed lower concentrations or shorter durations being intermediate. In experiment 3, a total of 2,808 pigs were used in a 28-d trial with 13 feeders per treatment. All pigs were fed a common diet for 7 d after weaning. Pigs were then fed either a control diet (without any SMB-containing product) or a diet containing Product 1 (0.50% and 0.25% from days 0 to 21 and 21 to 28, respectively) or SMB (0.50% and 0.25% from days 0 to 21 and 21 to 28, respectively) or 0.25% SMB from days 0 to 28. Overall, pigs fed Product 1 or high-SMB diets had greater (P < 0.05) ADG compared with pigs fed low-SMB or control diets. In conclusion, results of these experiments indicate that in diets with low DON concentrations, these SMB-based products increased ADG compared with control diets.

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Section: Discussionmentioning

confidence: 99%

Effects of sodium metabisulfite additives on nursery pig growth

Shawk

Dritz

Goodband

et al. 2018

Translational Animal Science

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“…The impact of deoxynivalenol in feed grains on animal performance and health vary with type of livestock animals. The evident production losses were observed in non-ruminant animals, in particularly swine when vomitoxininfested grains were fed [40,41]. Research conducted with vomitoxin-infested barley indicates no apparent problems when fed to growing and finishing cattle or gestating or lactating beef cows [42].…”

Section: Deoxynivalenol Content In Wheatmentioning

confidence: 99%

Quality Assessment of Feed Wheat in Ruminant Diets

Yang¹,

Shen²

2018

Global Wheat Production

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With adverse growing and harvesting conditions as well as the fluctuation of grain pricing, there have increased supplies of feed wheat used as livestock feed. However, the majority of wheat has been used as feed for poultry and swine, and ruminant producers have been reluctant to use large quantities of wheat because feeding wheat increases the risk of rumen acidosis due to rapid wheat starch digestion in the rumen. To avoid this problem, animal producers often believe that they must limit the amount of wheat in the diet to 50% or less. This chapter summarizes some research findings published in peer reviewed and extension articles on the use of feed wheat in ruminant diets. Substantial variation in physical and chemical composition exists among wheat samples, which are mainly influenced by type of wheat, variety and environmental conditions. Feed values of wheat are largely influenced by its physical properties and nutrient content; however, grain processing as well as its interaction with the physical characteristics is a critical consideration to optimize wheat utilization in ruminant diets. Wheat grain can be fed to animals at higher than typically used in the current livestock industry if proper bunk management and processing are employed.

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“…The predominant method of preventing and controlling mycotoxins is to incorporate mycotoxin detoxifiers into feed additives [15][16][17][18][19]. Mycotoxin detoxifiers are focused on reducing mycotoxin toxicity affecting animal health [20][21][22][23]. There are two types of mycotoxin-detoxifying agents: (a) the mycotoxin binders, which adsorb mycotoxins in the gastrointestinal tract (GIT), promote the excretion of mycotoxin-binder complexes in feces and forestall the uptake of mycotoxins; and (b) the mycotoxin modifiers, which are bio-transforming agents whose action is based on the conversion of mycotoxins by microorganisms/enzymes into non-toxic or less toxic metabolites [24,25].…”

Section: Introductionmentioning

confidence: 99%

Effects of a Curcumin/Silymarin/Yeast-Based Mycotoxin Detoxifier on Redox Status and Growth Performance of Weaned Piglets under Field Conditions

Papatsiros,

Papakonstantinou,

Voulgarakis

et al. 2024

Toxins

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The aim of this in vivo study was to investigate the effects of a novel mycotoxin detoxifier whose formulation includes clay (bentonite and sepiolite), phytogenic feed additives (curcumin and silymarin) and postbiotics (yeast products) on the health, performance and redox status of weaned piglets under the dietary challenge of fumonisins (FUMs). The study was conducted in duplicate in the course of two independent trials on two different farms. One hundred and fifty (150) weaned piglets per trial farm were allocated into two separate groups: (a) T1 (control group): 75 weaned piglets received FUM-contaminated feed and (b) T2 (experimental group): 75 weaned piglets received FUM-contaminated feed with the mycotoxin-detoxifying agent from the day of weaning (28 days) until 70 days of age. Thiobarbituric acid reactive substances (TBARSs), protein carbonyls (CARBs) and the overall antioxidant capacity (TAC) were assessed in plasma as indicators of redox status at 45 and 70 days of age. Furthermore, mortality and performance parameters were recorded at 28, 45 and 70 days of age, while histopathological examination was performed at the end of the trial period (day 70). The results of the present study reveal the beneficial effects of supplementing a novel mycotoxin detoxifier in the diets of weaners, including improved redox status, potential hepatoprotective properties and enhanced growth performance.

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Effects of potential detoxifying agents on growth performance and deoxynivalenol (DON) urinary balance characteristics of nursery pigs fed DON-contaminated wheat

Cited by 4 publications

References 25 publications

Effects of sodium metabisulfite additives on nursery pig growth

Effects of sodium metabisulfite additives on nursery pig growth

Quality Assessment of Feed Wheat in Ruminant Diets

Effects of a Curcumin/Silymarin/Yeast-Based Mycotoxin Detoxifier on Redox Status and Growth Performance of Weaned Piglets under Field Conditions

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