Effects of Pre-Exposure to Hyperbaric Hyperoxia on High-Intensity Exercise Performance

Kawada, Shigeo; Fukaya, Kohei; Ohtani, Mitsuaki; Kobayashi, Kanako; Fukusaki, Chiho

doi:10.1519/jsc.0b013e31815eefa2

Cited by 16 publications

(30 citation statements)

References 20 publications

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“…In the present study, we used HBO treatments to influence bone formation. Exposure to hyperoxia and/or hyperbaric conditions increases the dissolved oxygen content in vivo [21], [22]. Although HBO treatments did not increase IGF-1 mRNA expression and Ob.S/BS, MAR and BRF increased significantly.…”

Section: Discussionmentioning

confidence: 93%

Hyperbaric Hyperoxia Accelerates Fracture Healing in Mice

et al. 2013

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Increased oxygen tension influences bone metabolism. This study comprised two main experiments: one aimed to determine the bone mineral apposition and bone formation rates in vivo under hyperbaric hyperoxia (HBO), and the other aimed to evaluate the effects of exposure to HBO on fracture healing. In experiment 1, male mice were exposed to HBO [90 min/day at 90% O2 at 2 atmospheres absolute (ATA) for 5 days]. In experiment 2, an open femur fracture model was created in mice, followed by exposure to HBO 5 times/week (90 min/day at 90% O2 at 2 ATA) for 6 weeks after surgery. In experiment 1, HBO treatment significantly increased the mineral apposition and bone formation rates in the lumbar vertebra and femur and type 1 collagen alpha 1 and alkaline phosphatase mRNA expression in the lumbar vertebra. In experiment 2, at 2 weeks after fracture, the fracture callus was significantly larger in the HBO group than in the non-HBO group. Furthermore, at 4 and 6 weeks after fracture, radiographic findings showed accelerated fracture healing in the HBO group. At 6 weeks after fracture, femur stiffness and maximum load were significantly higher in the HBO group than in the non-HBO group. Urinary 8-hydroxy-2′-deoxyguanosine and plasma calcium concentrations were not significantly different between groups. These results suggest that exposure to HBO enhances bone anabolism and accelerates fracture healing without causing oxidative DNA damage or disruption of plasma calcium homeostasis.

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Section: Discussionmentioning

confidence: 93%

Hyperbaric Hyperoxia Accelerates Fracture Healing in Mice

et al. 2013

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“…Specifically, MMP-9 is a member of the gelatinase family, also including MMP-2, which is known to be highly expressed in damaged and regenerating livers [40]–[41]. MMP-9 expression has been found to be modified in lung following hyperoxia [42]–[43]. MMP-9 plays an important role in the structural changes consequent to oxygen-induced lung injury in newborn mice [42].…”

Section: Discussionmentioning

confidence: 99%

Postnatal Hyperoxia Exposure Differentially Affects Hepatocytes and Liver Haemopoietic Cells in Newborn Rats

et al. 2014

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Premature newborns are frequently exposed to hyperoxic conditions and experimental data indicate modulation of liver metabolism by hyperoxia in the first postnatal period. Conversely, nothing is known about possible modulation of growth factors and signaling molecules involved in other hyperoxic responses and no data are available about the effects of hyperoxia in postnatal liver haematopoiesis. The aim of the study was to analyse the effects of hyperoxia in the liver tissue (hepatocytes and haemopoietic cells) and to investigate possible changes in the expression of Vascular Endothelial Growth Factor (VEGF), Matrix Metalloproteinase 9 (MMP-9), Hypoxia-Inducible Factor-1α (HIF-1α), endothelial Nitric Oxide Synthase (eNOS), and Nuclear Factor-kB (NF-kB). Experimental design of the study involved exposure of newborn rats to room air (controls), 60% O2 (moderate hyperoxia), or 95% O2 (severe hyperoxia) for the first two postnatal weeks. Immunohistochemical and Western blot analyses were performed. Severe hyperoxia increased hepatocyte apoptosis and MMP-9 expression and decreased VEGF expression. Reduced content in reticular fibers was found in moderate and severe hyperoxia. Some other changes were specifically produced in hepatocytes by moderate hyperoxia, i.e., upregulation of HIF-1α and downregulation of eNOS and NF-kB. Postnatal severe hyperoxia exposure increased liver haemopoiesis and upregulated the expression of VEGF (both moderate and severe hyperoxia) and eNOS (severe hyperoxia) in haemopoietic cells. In conclusion, our study showed different effects of hyperoxia on hepatocytes and haemopoietic cells and differential involvement of the above factors. The involvement of VEGF and eNOS in the liver haemopoietic response to hyperoxia may be hypothesized.

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“…Acute exposure to normobaric hyperoxia (i.e., 60% to 100% O 2 ) increases O 2 availability and may improve physical performance in a dose-dependent manner [5, 6]. However, It has been shown that preexercise exposure to normobaric hyperoxia did not modify the performance during high intensity exercise [7, 8], endurance exercise [9], or resistance training [7]. Similarly, preexposure to HBO 2 has no acute effect on physical performance [10, 11].…”

Section: Introductionmentioning

confidence: 99%

“…However, the probability of these symptoms to appear only increases after 4 h of diving [19, 20]. Thus, it is still a matter of debate if HBO 2 training may induce harmful effects as oxidative stress [7, 21]. …”

Section: Introductionmentioning

confidence: 99%

Effects of Exercise Training under Hyperbaric Oxygen on Oxidative Stress Markers and Endurance Performance in Young Soccer Players: A Pilot Study

Burgos

Henríquez‐Olguín

Andrade

et al. 2016

Journal of Nutrition and Metabolism

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The aim of the present study was to determine the effects of three weeks of hyperbaric oxygen (HBO2) training on oxidative stress markers and endurance performance in young soccer players. Participants (18.6 ± 1.6 years) were randomized into hyperbaric-hyperoxic (HH) training (n = 6) and normobaric normoxic (NN) training (n = 6) groups. Immediately before and after the 5th, 10th, and 15th training sessions, plasma oxidative stress markers (lipid hydroperoxides and uric acid), plasma antioxidant capacity (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid [TROLOX]), arterial blood gases, acid-base balance, bases excess (BE), and blood lactate analyses were performed. Before and after intervention, maximal oxygen uptake (VO2max) and peak power output (PPO) were determined. Neither HH nor NN experienced significant changes on oxidative stress markers or antioxidant capacity during intervention. VO2max and PPO were improved (moderate effect size) after HH training. The results suggest that HBO2 endurance training does not increase oxidative stress markers and improves endurance performance in young soccer players. Our findings warrant future investigation to corroborate that HBO2 endurance training could be a potential training approach for highly competitive young soccer players.

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Effects of Pre-Exposure to Hyperbaric Hyperoxia on High-Intensity Exercise Performance

Cited by 16 publications

References 20 publications

Hyperbaric Hyperoxia Accelerates Fracture Healing in Mice

Hyperbaric Hyperoxia Accelerates Fracture Healing in Mice

Postnatal Hyperoxia Exposure Differentially Affects Hepatocytes and Liver Haemopoietic Cells in Newborn Rats

Effects of Exercise Training under Hyperbaric Oxygen on Oxidative Stress Markers and Endurance Performance in Young Soccer Players: A Pilot Study

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