Effects of prenatal perfluorooctane sulfonate (PFOS) exposure on lung maturation in the perinatal rat

Abstract

Morphometric changes in lungs of PFOS exposed neonates were suggestive of immaturity, but the failure of rescue agents and normal pulmonary surfactant profile indicate that the labored respiration and mortality observed in PFOS-treated neonates was not due to lung immaturity.

Transplacental exposure of neonates to perfluorooctanesulfonate and perfluorooctanoate: a pilot study

“…In animal studies both substances caused developmental toxicity: Postnatal mortality, birth defects and deWcits regarding growth and development of rodent pups could be associated with PFOS and PFOA exposure of the parental generation (ButenhoV et al 2002Christian et al 1999;Grasty et al 2003Grasty et al , 2005Lau et al 2003Lau et al , 2004Lau et al , 2006Luebker et al 2005a, b;Thibodeaux et al 2003). For PFOS the lowest reported NOAEL for oVspring eVects in rats is 0.4 mg/kg (Luebker et al 2005a).…”

“…In animal studies PFOS and PFOA induced tumours and developmental toxic eVects (3M 2002;ButenhoV et al 2002Christian et al 1999;Grasty et al 2003Grasty et al , 2005Lau et al 2003Lau et al , 2004Lau et al , 2006Luebker et al 2005a, b;Thibodeaux et al 2003;US EPA 2003). The toxicological proWles in respect to human health eVects has been reviewed (OECD 2002;US EPA 2005) and in particular the developmental toxicity is in the focus of recent studies Lau et al 2003Lau et al , 2004Lau et al , 2006Luebker et al 2005a, b;Thibodeaux et al 2003).…”

Chronic exposure to perfluorinated compounds: Impact on airway hyperresponsiveness and inflammation

“…Multiple reports, in a variety of animal models, paint a concerning picture of the potential for PFOA and PFOS to contribute to negative health effects, including developmental toxicity (23) and pulmonary complications resulting in neonatal mortality (12,13). In humans, there is evidence of higher (self-reported) shortness of breath and asthma among people who had been exposed to PFOA via drinking water (1).…”

Referenzwerte für Perfluoroctansäure (PFOA) und Perfluoroctansulfonsäure (PFOS) im Blutplasma

“…Tierexperimentelle Untersuchungen lassen darauf schließen, dass sowohl PFOA als auch PFOS als entwicklungsschädigend und Krebs erzeugend einzustufen sind [21,22,23,24,25,26,27,28,29,30,31,32]. In einer Studie von Apelberg et al [33] wurde eine statistisch signifikante Assoziation zwischen PFOA-und PFOS-Konzentrationen im Nabelschnurblut und geringeren Geburtsgewichten sowie geringeren Kopfumfängen bei Neugeborenen festgestellt.…”