Effects of prenatal stress on cellular and humoral immune responses in neonatal pigs

Tuchscherer, Margret; Kanitz, Ellen; Otten, Winfried; Tuchscherer, Armin

doi:10.1016/s0165-2427(02)00035-1

Cited by 145 publications

(125 citation statements)

References 35 publications

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“…Only one study demonstrated a clear effect of prenatal stress on mortality. In this study, repeated nose sling restraint during the last third of gestation more than doubled the mortality of the piglets during the suckling period (Tuchscherer et al, 2002).…”

Section: Introductionmentioning

confidence: 57%

“…In pigs, treatment of the mother with ACTH during the last third of gestation did not affect the frequency of diseased piglets during the lactation period (Otten et al, 2007). However, a strong behavioral stressor involving pain applied at the same gestational period increased the number of diseased piglets per litter until weaning (Tuchscherer et al, 2002). Studies that did not measure the occurrence of disease events directly but assessed blood levels of health markers, such as acute phase proteins and inflammatory cytokines, failed to find a clear effect of prenatal stress.…”

Section: Introductionmentioning

confidence: 94%

“…To the best of our knowledge, the impact of psychological stress on colostrum yield and gross composition has not been investigated. In pigs, psychological stress during the last third of pregnancy had no effect on IgG contents in colostrum (Tuchscherer et al, 2002;Couret et al, 2009a).…”

Section: Effect Of Maternal Stress During Gestation On Maternal Qualimentioning

confidence: 99%

“…Besides effects on colostrum composition and quantity, late gestational stress can also decrease the ability of the offspring to acquire maternal immunity from colostrum. For example, decreased blood IgG contents were observed in piglets whose mothers were exposed to stress during late pregnancy, whereas IgG levels in the colostrum were not altered (Tuchscherer et al, 2002). There are no data investigating whether prenatal stress affects the amount of colostrum that neonates ingest, but indirect measurements suggest that this is unlikely the case.…”

Section: Effect Of Maternal Stress During Gestation On the Biology Ofmentioning

confidence: 99%

“…Models of prenatal stress in farm animal species Most of the studies investigating the influence of prenatal stress on factors influencing neonatal survival and immunity in farm animals focused on pigs, using behavioral stressors such as nose sling restraint that involves pain (Tuchscherer et al, 2002), rough treatment (Lay et al, 2011) or social stress (Jarvis et al, 2006;Couret et al, 2009b). Experiments were also conducted using artificial activation of the maternal corticotrope axis with adrenocorticotropic hormone (ACTH) injections (Haussmann et al, 2000;Otten et al, 2007) or mimicking corticotrope axis activation by providing pregnant sows with oral cortisol (Kranendonk et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Prenatal stress, immunity and neonatal health in farm animal species

Merlot

Quesnel

Prunier

2013

Animal

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The high pre-weaning mortality in farm animal species and poor welfare conditions of reproductive females question modern industrial farming acceptability. A growing body of literature has been produced recently, investigating the impact of maternal stress during gestation on maternal and offspring physiology and behavior in farm animals. Until now, the possible impact of prenatal stress on neonatal health, growth and survival could not be consistently demonstrated, probably because experimental studies use small numbers of animals and thus do not allow accurate estimations. However, the data from literature synthesized in the present review show that in ungulates, maternal stress can sometimes alter important maternal parameters of neonatal survival such as colostrum production (ruminants) and maternal care to the newborn (pigs). Furthermore, maternal stress during gestation can affect maternal immune system and impair her health, which can have an impact on the transfer of pathogens from the mother to her fetus or neonate. Finally, prenatal stress can decrease the ability of the neonate to absorb colostral immunoglobulins, and alter its inflammatory response and lymphocyte functions during the first few weeks of life. Cortisol and reproductive hormones in the case of colostrogenesis are pointed out as possible hormonal mediators. Field data and epidemiological studies are needed to quantify the role of maternal welfare problems in neonatal health and survival.

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Section: Introductionmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 94%

Section: Effect Of Maternal Stress During Gestation On Maternal Qualimentioning

confidence: 99%

Section: Effect Of Maternal Stress During Gestation On the Biology Ofmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prenatal stress, immunity and neonatal health in farm animal species

Merlot

Quesnel

Prunier

2013

Animal

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show abstract

Immune System

Chase¹,

Lunney²

2019

Diseases of Swine

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Using Natural Disasters to Study the Effects of Prenatal Maternal Stress on Child Health and Development

King

Dancause

Turcotte-Tremblay

et al. 2012

Birth Defects Research Pt C

207

208

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Research on the developmental origins of health and disease highlights the plasticity of the human fetus to a host of potential teratogens. Experimental research on laboratory animals has demonstrated a variety of physical and behavioral effects among offspring exposed to prenatal maternal stress (PNMS). However, these studies cannot elucidate the relative effects of the objective stress exposure and the subjective distress in a way that would parallel the stress experience in humans. PNMS research with humans is also limited because there are ethical challenges to designing studies that involve the random assignment of pregnant women to varying levels of independent stressors. Natural disasters present opportunities for natural experiments of the effects of pregnant women's exposure to stress on child development. In this review, we present an overview of the human and animal research on PNMS, and highlight the results of Project Ice Storm which has been following the cognitive, behavioral, motor and physical development of children exposed in utero to the January 1998 Quebec Ice Storm. We have found that both objective degree of exposure to the storm and the mothers' subjective distress have strong and persistent effects on child development, and that these effects are often moderated by the timing of the ice storm in pregnancy and by the child's sex.

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Effects of prenatal stress on cellular and humoral immune responses in neonatal pigs

Cited by 145 publications

References 35 publications

Prenatal stress, immunity and neonatal health in farm animal species

Prenatal stress, immunity and neonatal health in farm animal species

Immune System

Using Natural Disasters to Study the Effects of Prenatal Maternal Stress on Child Health and Development

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