Effects of preoperative administration of ketoprofen on whole blood platelet aggregation, buccal mucosal bleeding time, and hematologic indices in dogs undergoing elective ovariohysterectomy

Abstract

Preoperative administration of ketoprofen inhibited platelet aggre gation but did not alter bleeding time. Ketoprofen can be given before surgery to healthy dogs undergoing elective ovariohysterectomy, provided that dogs are screened for potential bleeding problems before surgery and monitored closely after surgery.

Comparison of Laparoscopic Ovariohysterectomy and Ovariohysterectomy in Dogs

“…The dogs that we evaluated were administered ketoprofen, an effective postoperative analgesic. 26,27 Although the complete assessment of pain attributed to OVH and LOVH would require no analgesic or anti-inflammatory drug administration, this would not be appropriate, so we administered ketoprofen to dogs in both groups. Significantly lower scores for some pain descriptors in LOVH dogs suggested that LOVH may be a less painful surgical procedure than OVH in dogs.…”

Monitoring side effects of long‐term NSAID use in dogs with chronic osteoarthritis

“…Reduced platelet aggregation and increased coagulation times were noted in some cases; however, the affected dogs had normal BMBT, platelet number and morphology. Coagulopathy, at doses commonly used in veterinary medicine, is a theoretical risk of NSAID use, but has not been shown to be clinically relevant in healthy dogs (Hickford and others 2001, Lemke and others 2002, Luna and others 2007). …”

Perioperative use of non‐steroidal anti‐inflammatory drugs in cats and dogs

“…Therefore, NSAIDs that inhibit COX-1 have the potential to decrease haemostasis and this is a concern in animals undergoing surgery. Ketoprofen has been shown to reduce platelet aggregation in dogs undergoing ovariohysterectomy, although there was no concurrent effect on buccal mucosal bleeding time, questioning the clinical relevance of this finding (Lemke and others 2002). In another study carprofen did not cause clinically relevant changes in markers of haemostasis in dogs undergoing fracture repair (Bergmann and others 2005).…”