Effects of preovulatory estradiol on embryo survival and pregnancy establishment in beef cows

Madsen, Crystal A.; Perry, George A.; Mogck, C. L.; Daly, Russ; MacNeil, M. D.; Geary, T. W.

doi:10.1016/j.anireprosci.2015.05.006

Cited by 60 publications

(39 citation statements)

References 21 publications

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“…The increased serum concentrations of FSH and LH combined with the increased receptors in the ovary enhanced ovary function, which agrees with the findings of Zabuli et al (), who reported that short‐term dietary supplementation stimulated pulsatile LH secretion in ovariectomized goats. In addition, serum E 2 , important for embryo survival and pregnancy establishment (Madsen et al ), and P increased in both the CS and BS groups, which indicated that uterine receptivity was improved. ERα mRNA expression in the hypothalamus AVPV area was also higher in the CS and BS groups than in the CON group.…”

Section: Discussionmentioning

confidence: 91%

Effect of supplements during the cold season on the reproductive system in prepubertal Tibetan sheep ewes

Jing

Peng

et al. 2017

Animal Science Journal

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We examined the development of the reproductive system in prepubertal Tibetan sheep ewes when fed only oat hay (CON) or supplemented with either lick blocks (BS) or concentrate feed (CS) during the cold season. The average daily gain of the CS ewes was greater than that of the BS ewes (P < 0.05), which was greater than that of the CON ewes. The same pattern was observed in the number of ovarian follicles (P < 0.001), that is, CS > BS > CON. Serum concentrations of gonadotropin-releasing hormone, follicle-stimulating hormone, luteotrophic hormone, estradiol and progesterone in the CS and BS groups were higher than in the CON group (P < 0.05). The messenger RNA (mRNA) expression of KiSS-1, GPR54 (G protein-coupled receptor 54), ERα (estradiol receptor α) in the hypothalamic anteroventral periventricular area of the CS group were higher than in both the BS and CON groups (P < 0.05), while the BS group was higher than in the CON group (P < 0.05). Similar differences among groups were observed for gonadotropin-releasing hormone receptor mRNA expression in the pituitary, follicle-stimulating hormone receptor and luteinizing hormone receptor mRNA expression in the ovary. These results indicated that the KiSS1/GPR54 system was more active with nutrition or trace mineral supplementation during the cold season. The system stimulated the hypothalamic-pituitary-gonadal axis and enhanced folliclar development in prepubertal Tibetan sheep ewes. We concluded that energy, protein and trace minerals supplements could improve the reproductive performance of Tibetan sheep on the Qinghai-Tibetan plateau.

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Section: Discussionmentioning

confidence: 91%

Effect of supplements during the cold season on the reproductive system in prepubertal Tibetan sheep ewes

Jing

Peng

et al. 2017

Animal Science Journal

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“…oviductal glycoprotein; reviewed by Buhi, 2002), by modulating progesterone action via induction of progesterone receptors in the uterus (Stone et al, 1978;Zelinski et al, 1982;Ing and Tornesi, 1997), and(or) by increasing luteal progesterone secretion. Madsen et al (2015) demonstrated the necessity of preovulatory estradiol on embryo survival and placental attachment in beef cows using an ovariectomized cow model. In regards to the latter effect of estradiol, reported that circulating concentration of estradiol at FTAI (day 0) was positively associated with serum concentrations of progesterone on day 7 and independent of ovulatory follicle size.…”

Section: Role Of Proestrus and Preovulatory Estradiolmentioning

confidence: 99%

Effect of preovulatory follicle maturity on pregnancy establishment in cattle: the role ofoocyte competence and the maternal environment

Dickinson¹,

Geary²,

Monnig³

et al. 2016

Anim Reprod

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Reproductive technologies to synchronize estrus and ovulation in cattle have enhanced the ability to practically utilize artificial insemination to increase both genetic merit and reproductive management of beef and dairy herds. The ability to successfully synchronize a follicular wave and ovulation, in heifers and cows, has improved substantially in recent years. Consequently, pregnancy rates to a single fixed-time artificial insemination (FTAI) can approximate that of insemination following spontaneous estrus. Despite these advances, a subset of heifers and cows often has a physiologically immature dominant follicle at the time of GnRH-induced ovulation. These animals will exhibit reduced pregnancy rates and decreased embryonic survival if a pregnancy happens to become established. The physiological mechanisms underlying the preceding decreased fertility have been a focus of our laboratories and may include an effect of the follicular microenvironment on both oocyte competence and the maternal environment. Oocytes must have adequate opportunity to complete cytoplasmic and molecular maturation during the final stages of oocyte maturation that occur within the preovulatory follicle. Follicular status, during the proestrus period, must be such that adequate circulating concentrations of estradiol are present before FTAI to increase oviductal transport of gametes and enhance both the luteinizing capacity of granulosa cells and progesterone receptor population in the post-ovulatory uterus. Following ovulation, the follicle's transformation to a functional corpus luteum to secrete adequate amounts of progesterone is essential for the establishment of pregnancy. The physiological status of the preovulatory follicle, prior to FTAI, greatly affects the concepts discussed above and has an important impact on pregnancy establishment and maintenance in cattle.

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“…High levels of estradiol produced by ovarian follicles during proestrous and estrous result in increased uterine blood flow, promote uterine contractions assisting sperm transport, and affect the uterine environment increasing the chance of embryo survival, possibly by sustaining embryonic growth and the development of placenta (Madsen et al, 2015) The ovulatory follicle's production of estradiol and the subsequent corpus luteum's progesterone production are now also shown to be related to changes in tissue, cells and secretions in both the oviduct and the uterus . These changes are also stimulated by the conceptus (INF-t, prostaglandins, cortisol), and the endometrium (prostaglandins, cortisol), and altogether are affecting uterine physiology and receptivity (Forde et al, 2009(Forde et al, , 2011.…”

Section: Preparations In the Embryo Recipientmentioning

confidence: 99%

Basic and practical aspects of pregnancy establishment in cattle

Pedersen¹,

Mazzoni²,

Stroebech³

et al. 2017

Anim Reprod

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Bovine embryos are increasingly produced using reproductive technologies, e.g. ovum pick-up (OPU), in vitro embryo production (IVP) and embryo transfer (ET). Such in vitro manipulated embryos are known to deviate in several aspects compared to in vivo derived embryos. Pregnancy establishment in cattle involves timed biological events including fine-tuned communication, initiated and carried out by both the embryo and the endometrium. This stimulates research to increase the understanding of events and interactions taking place in the uterus after embryo transfer, both from a biological and systems biology point of view. This review will focus on the biological events taking place during early embryonic development, implantation and beginning of placentation, with focus on transfer of in vitro produced embryos, including a systems biology approach for selection of superior embryo recipients.

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Effects of preovulatory estradiol on embryo survival and pregnancy establishment in beef cows

Cited by 60 publications

References 21 publications

Effect of supplements during the cold season on the reproductive system in prepubertal Tibetan sheep ewes

Effect of supplements during the cold season on the reproductive system in prepubertal Tibetan sheep ewes

Effect of preovulatory follicle maturity on pregnancy establishment in cattle: the role ofoocyte competence and the maternal environment

Basic and practical aspects of pregnancy establishment in cattle

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