Effects of preterm birth and fetal growth retardation on life-course cardiovascular risk factors among schoolchildren from Colombia: The FUPRECOL study

Ramírez‐Vélez, Robinson; Correa-Bautista, Jorge Enrique; Villa‐González, Emilio; Martínez-Torres, Javier; Hackney, Anthony C.; García-Hermoso, António

doi:10.1016/j.earlhumdev.2017.02.001

Cited by 25 publications

(33 citation statements)

References 24 publications

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“…A pesar que la determinación y evaluación de los resultados del nacimiento son herramientas útiles para predecir la morbimortalidad neonatal 12,13 , además de ser factores de riesgo para el desarrollo de enfermedades m etab ó l ic a s 4,5 ; pocos son los estudios realizados a nivel nacional que analizan el peso al nacer, nacimiento pretérmino y PEG en el tiempo 14,15 , y los factores que lo influyen 16 ; siendo el presente trabajo preliminar, la contribución más actualizada en lo que respecta al tema.…”

Section: Discussionunclassified

“…A su vez, diversos estudios han permitido relacionar los resultados adversos del nacimiento como, nacimiento prematuro, bajo peso al nacer o pequeño para la edad gestacional (PEG), como factores de riesgo para el desarrollo de enfermedades metabólicas como diabetes mellitus tipo 2, dislipidemias, enfermedades cardiovasculares, infarto al miocardio, etc., durante la vida adulta 4,5 .…”

Section: Introductionunclassified

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Resultados preliminares del análisis de bajo peso al nacer, nacimiento pretérmino y pequeño para la edad gestacional, reportados en la base de datos del Instituto Nacional Materno Perinatal durante los años 2012-2017

Fano-Sizgorich¹,

Ayala-Peralta²,

Carranza-Asmat³

et al. 2019

Investigación Materno Perinatal

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Objetivo. Evaluar los cambios ocurridos desde el 2012 al 2017, y analizar los factores que influyen sobre ellas. Material y métodos. Se analizó la base estadística materno-perinatal manejada por el Instituto Nacional Materno Perinatal. Se incluyeron todos aquellos partos pertenecientes a Lima Metropolitana, nacidos vivos, de partos únicos, obteniéndose un total de 107 581 partos. Se realizó un análisis multivariado ajustando por distintas variables obstétricas y socioeconómicas. Resultados. No se obtuvo cambios significativos de Bajo Peso al Nacer, Nacimiento Pretérmino y PEG entre los distintos años. En los tres casos, la anemia leve estaría actuando como un factor protector 0,91 (0,74-1,1), 0,80 (0,72-0,90) y 0,85 (0,76-0,95), respectivamente; en donde el grado de anemia leve es protector para Nacimiento Pretérmino y PEG. Mientras que la preeclampsia es el factor de riesgo de mayor influencia, OR: 2.90 (2,25-3,73), 5,23 (4,61-5,98) y 3,00 (2,57-3,49), respectivamente. Conclusión. El riesgo de Bajo Peso al Nacer, Nacimiento Prematuro y PEG no varió significativamente en el periodo 2012-2017 al controlarse por las demás variables. La anemia leve debe de considerarse como un factor protector ante resultados perinatales adversos, mientras que la eritrocitosis como uno de riesgo. Dado su impacto sobre los resultados perinatales, es imperativo estudiar los factores que predisponente a padecer de preeclampsia.

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Section: Discussionunclassified

Section: Introductionunclassified

Resultados preliminares del análisis de bajo peso al nacer, nacimiento pretérmino y pequeño para la edad gestacional, reportados en la base de datos del Instituto Nacional Materno Perinatal durante los años 2012-2017

Fano-Sizgorich¹,

Ayala-Peralta²,

Carranza-Asmat³

et al. 2019

Investigación Materno Perinatal

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“…These findings suggest that metabolic alterations in SGA are caused by both adverse fetal programming and obesity. In a recent study, school-age children and adolescents with combined fetal growth restriction and prematurity (preterm SGA) exhibited an increased prevalence of glucose risk and metabolic syndrome compared with term SGA or preterm AGA [ 44 ]. This indicates that prematurity alone does not impact metabolic risk, while suggesting the influence of being born SGA [ 44 ].…”

Section: Sga and Metabolic Syndromementioning

confidence: 99%

Small for gestational age and obesity related comorbidities

Hong

Chung

2018

Ann Pediatr Endocrinol Metab

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Infant born small for gestational age (SGA) are at increased risk of perinatal morbidity, persistent short stature and metabolic alterations in later life. The result of SGA followed by rapid weight gain during early postnatal life has been associated with increased long-term risks for central obesity, insulin resistance, impaired glucose tolerance, type 2 diabetes, hypertension, increased fat mass, and cardiovascular disease. We should carefully monitor their weight during infancy and childhood to prevent excessive rates of weight gain. ‘Healthy catch up growth’ may decreased the risk of obesity-related comorbidities in SGA. Establishing the optimal growth patterns in SGA to minimize short- and long-term risks is important, and further studies will be needed. This review discusses recent studies concentrating on obesity-related morbidities in SGA infants that may provide insight into growth monitoring.

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“…Surviving E/VPNs are at increased risk for neurodevelopmental abnormalities, including cognitive impairment, learning disabilities, and mental health issues ( 2 – 4 ). Those E/VPNs who experienced intrauterine growth restriction (IUGR) are at even greater risk of adverse neurodevelopmental outcomes and cardiometabolic derangement ( 5 , 6 ). IUGR has also been shown to cause a multitude of short- and long-term complications involving almost all organ systems ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

The SLC25A42 Transcript Is a Biomarker for Fetal Reprogramming in Response to Placental Insufficiency in Preterm Newborns Under 32 Weeks Gestation—A Pilot Study

Chou

Wang

2020

Front. Pediatr.

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Introduction: Timing of medical delivery of preterm newborns exposed to placental insufficiency is largely determined by umbilical artery blood flow and maternal clinical manifestations. There is a lack of tools to properly assess fetal body response to placental insufficiency before or upon delivery. Yet, short- and long-term comorbidities associated with placental insufficiency and the consequential intrauterine growth restriction may be a result of fetal response following prolonged stress. This study aims to establish a procedure to investigate fetal/neonatal transcriptional response to placental insufficiency as part of an initiative to identify cost-effective biomarkers for assessing fetal response to placental insufficiency. Methods: A prospective pilot study involving newborns with birth gestation <32 weeks was conducted to compare gene expression profiles in whole blood collected at birth among three clinically distinct groups - preeclampsia without placental insufficiency (PE), placental insufficiency (PI), and non-PE/PI groups. Results: Whole blood from 11, 3, and 6 newborns in the non-PE/PI, PE, and PI groups were obtained. A transcriptome analysis found that the majority of the genes were downregulated in the PI group, suggesting global transcriptional inactivation. Intriguingly, SLC25A42, which encodes a mitochondrial transporter for coenzyme A and adenosine-3′,5′-diphosphate, was significantly upregulated in the PI group. Conclusion: Transcriptional biomarkers for assessing fetal response to placental insufficiency may provide a useful tool to better understand the pathophysiology of fetal reprogramming in response to placental insufficiency. The validity and the role of SLC25A42, as well as its correlation with short- and long-term neonatal outcomes, warrants further investigation.

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Effects of preterm birth and fetal growth retardation on life-course cardiovascular risk factors among schoolchildren from Colombia: The FUPRECOL study

Cited by 25 publications

References 24 publications

Resultados preliminares del análisis de bajo peso al nacer, nacimiento pretérmino y pequeño para la edad gestacional, reportados en la base de datos del Instituto Nacional Materno Perinatal durante los años 2012-2017

Resultados preliminares del análisis de bajo peso al nacer, nacimiento pretérmino y pequeño para la edad gestacional, reportados en la base de datos del Instituto Nacional Materno Perinatal durante los años 2012-2017

Small for gestational age and obesity related comorbidities

The SLC25A42 Transcript Is a Biomarker for Fetal Reprogramming in Response to Placental Insufficiency in Preterm Newborns Under 32 Weeks Gestation—A Pilot Study

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