Effects of probiotic Lactobacillus salivarius WB21 on halitosis and oral health: an open-label pilot trial

Iwamoto, Tomoyuki; Suzuki, Nao; Tanabe, Kazunari; Takeshita, Toru; Hirofuji, Takao

doi:10.1016/j.tripleo.2010.03.032

Cited by 104 publications

(72 citation statements)

References 32 publications

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“…After taking L. salivarius WB21 and xylitol in tablet form daily, the scores of an organoleptic test and bleeding on probing significantly decreased after 4 weeks [77]. In a randomised doubleblind, placebo-controlled cross-over trail with 25 adults a probiotic chewing gum with L. reuteri DSM 17938 and L. reuteri ATCC PTA 5289 or placebo was used.…”

Section: Halitosismentioning

confidence: 99%

Lactobacilli for the Treatment of Oral Diseases

Hoffmann¹,

Daniels²

2017

J Prob Health

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Probiotics are defined as live microorganisms that beneficially affect the host. Probiotic bacteria have been used therapeutically for years to target gastrointestinal disease by rebalancing the complex microflora. Besides the gastrointestinal tract also the oral cavity is highly colonized by bacteria and many different bacterial species are part of the microbiota in the mouth, as it offers ideal conditions for bacteria with a stable temperature, moist surface with a relatively stable pH and regular supply of nutrients. By disturbing the balance of microorganisms in the oral cavity or by extensive accumulation of plaque, the ratio of pathogenic organisms can increase and lead to oral health problems. Probiotic bacteria, like lactobacilli, are a promising treatment strategy for oral diseases with a microbiological aetiology. Those include plaqueassociated diseases like dental caries, which is an infectious disease with microbial processes eroding and destroying the hard dental tissue or inflammation of periodontal tissue, namely gingivitis and the more severe periodontitis. Moreover, endodontic infections, and even fungal, viral and acute bacterial infections could be treated by a probiotic therapy. The interest of probiotics in the field of oral health is growing, although it is still in its infancy. The present review adresses criteria for the selection of probiotic lactobacilli strains. It encompasses existing evidence on the use of lactobacilli for caries, halitosis and candidiasis, as well as for periodontal disease like Gingivitis and periodontitis.

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Section: Halitosismentioning

confidence: 99%

Lactobacilli for the Treatment of Oral Diseases

Hoffmann¹,

Daniels²

2017

J Prob Health

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“…Weissella cibaria also competed with secondary colonizers for adhesion sites thereby slowing down the transmission to more pathogenic plaque 9 . When Lactobacillus salivarius WB12 and xylitol in tablet form were given daily to patients with genuine halitosis for a period of 4 weeks, a statistically significant reduction in the organoleptic scores of halitosis and bleeding on probing were observed 10 . Streptococcus salivarius is another microorganism that has the potential to reduce halitosis by virtue of its ability to produce bacteriocins and salivaricins that reduces the number of bacteria that produce volatile sulphur compounds.…”

Section: Probiotics and Halitosismentioning

confidence: 99%

Probiotics in Periodontal Diseases

Joseph¹

2014

IOSRJDMS

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“…Biological therapeutic agents, such as lactoferrin and probiotic bacteria, have been employed to control oral malodor [55,56]. These treatments may involve fewer side effects and are environmentally safe.…”

Section: Biological Therapeutic Approachmentioning

confidence: 99%

“…Recently, some studies concerning the effect of probiotic bacteria on maintaining oral health have been reported [60][61][62]. An open-label pilot trial using tablets containing Lactobacillus salivarius WB21 and xylitol reported that VSC levels (H 2 S and CH 3 SH) and OLS were significantly lower at two weeks in subjects with physiologic halitosis, and OLS and bleeding on probing were significantly lower at four weeks in subjects with oral pathologic halitosis [55]. Quantitative analysis by real-time PCR found that L. salivarius and P. intermedia numbers were significantly increased in subjects with oral pathologic halitosis at two weeks, but levels of other VSC-producing periodontal bacteria and total bacteria in the saliva were unchanged.…”

Section: Biological Therapeutic Approachmentioning

confidence: 99%