Effects of probiotic supplementation on the regulation of blood lipid levels in overweight or obese subjects: a meta-analysis

Yan, Shoumeng; Tian, Zhen-Wei; Li, Meng; Li, Bo; Cui, Weiwei

doi:10.1039/c8fo02163e

Cited by 43 publications

(31 citation statements)

References 50 publications

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“…Dyslipidemia increases the global disease burden, and elevated plasma LDL-C levels are the main risk factors for cardiovascular and cerebrovascular diseases [28]. Supplementing probiotics can improve the lipid metabolism of obese or overweight people, and can significantly reduce TC and LDL levels especially [29]. The mechanisms of probiotics regulating lipid metabolism mainly include reducing the absorption of lipids in organisms, reducing fat intake, and inhibiting the activity of key enzymes in fatty acid synthesis and metabolism.…”

Section: Discussionmentioning

confidence: 99%

Preventive Effect and Molecular Mechanism of Lactobacillus rhamnosus JL1 on Food-Borne Obesity in Mice

et al. 2021

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Probiotics can prevent obesity and related metabolic complications. In our study, the protective effect and molecular mechanism of Lactobacillus rhamnosus JL1 (separated from the feces of healthy infants) on high-fat diet mice were investigated. After 10 weeks of dietary intervention with L. rhamnosus JL1 intervention, the body weight of the JL1 group (23.78 g) was significantly lower than that of the HFD group (26.59 g, p < 0.05) and the liver index was reduced. Serum biochemical analysis showed that the TC, TG and LDL-C contents of JL1 group mice were significantly decreased (p < 0.05). Histological images of the mice livers showed that the degree of lipid action and damage of hepatic cells were improved. L. rhamnosus JL1 activated the AMPK pathway, and reduced the gene expression of PPAR-γ, LXR-α and SREBP-1C. In addition, the protein expression of PPAR-γ and LXR-α were reduced. After dietary intervention with L. rhamnosus JL1, the concentration of acetic acid, propionic acid, and butyric acid were increased significantly, especially the concentration of butyric acid, which was 63.16% higher than that of the HFD group (p < 0.05). In conclusion, this study provided a theoretical reference for the development and application of probiotics derived from healthy infant feces in health products and functional foods.

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Section: Discussionmentioning

confidence: 99%

Preventive Effect and Molecular Mechanism of Lactobacillus rhamnosus JL1 on Food-Borne Obesity in Mice

et al. 2021

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“…Probiotics are one group of dietary ingredients or food supplements that are widely used to modify the gut microbiota. In several recent meta-analyses including subjects with mild to moderate hypercholesterolemia, these agents have been demonstrated to improve lipid metabolism, particularly to lower the total and LDL-cholesterol [64][65][66][67]. Another group of nutraceuticals that has been of interest with regard to cardiovascular health is fish oil.…”

Section: Dietary Interventionsmentioning

confidence: 99%

How strong is the evidence that gut microbiota composition can be influenced by lifestyle interventions in a cardio-protective way?

et al. 2020

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“…Another meta-analysis also observed a slightly greater effect on SBP in hypertensive participants compared with normotensive ones [41]. Considering studies evaluating the effects of probiotics on lipid profile, recent meta-analyses revealed a statistically greater reduction in TC and LDL-col in trials with longer duration (>8 weeks) [31,67], using multiple probiotics strains [31,68], conducted in individuals with higher baseline TC [67,69] and presenting overweight or obesity [68].…”

Section: Discussionmentioning

confidence: 97%

Rationale and Design of a Randomized Controlled Trial to Evaluate the Effects of Probiotics during Energy Restriction on Blood Pressure, Body Composition, Metabolic Profile and Vascular Function in Obese Hypertensive Individuals

Guedes¹,

Pontes²,

Valença³

et al. 2020

Artery Res

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Hypertension often clusters with other CVDs risk factors such as overweight/obesity, dyslipidemia and glucose intolerance [6,7]. The relationship between hypertension and other CVDs risk factors is complex [6]. A nearly linear relationship exists between BP and indices of obesity. Excessive weight gain, especially when associated with visceral obesity, raises BP and is the most important known risk factor for primary (essential) hypertension [8]. The mechanisms of obesity induced hypertension have not been fully elucidated. However, several consequences of obesity may interact synergistically with hypertension favoring CVDs. These consequences include increased activity of sympathetic nervous system and of renin-angiotensin system, metabolic abnormalities (dyslipidemia and insulin resistance), inflammation, lipotoxicity, endothelial dysfunction and arterial stiffness [8][9][10][11].

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Effects of probiotic supplementation on the regulation of blood lipid levels in overweight or obese subjects: a meta-analysis

Abstract: Obesity is a risk factor for many deadly diseases.

Cited by 43 publications

References 50 publications

Preventive Effect and Molecular Mechanism of Lactobacillus rhamnosus JL1 on Food-Borne Obesity in Mice

Preventive Effect and Molecular Mechanism of Lactobacillus rhamnosus JL1 on Food-Borne Obesity in Mice

How strong is the evidence that gut microbiota composition can be influenced by lifestyle interventions in a cardio-protective way?

Rationale and Design of a Randomized Controlled Trial to Evaluate the Effects of Probiotics during Energy Restriction on Blood Pressure, Body Composition, Metabolic Profile and Vascular Function in Obese Hypertensive Individuals

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