Effects of probiotics on gastric microbiota and its precombination with quadruple regimen for Helicobacter pylori eradication

You, Wei; Dong, Xiaoli; Zhou, Xianzhu; Li, Zhao‐Shen; Du, Yiqi

doi:10.1111/1751-2980.13138

Cited by 3 publications

(2 citation statements)

References 47 publications

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“…However, probiotics administered in some studies also evaluated the same target strain as study outcome. Probiotic supplementation appears to reduce antibiotics-associated gut microbial imbalance and maintain a stable microbial ecosystem [59]. Probiotics alongside H. pylori therapy demonstrated a trend towards increased eradication consistent with the results from a previous meta-analysis [17].…”

Section: Discussionsupporting

confidence: 85%

Effects of Helicobacter pylori Therapy on Gut Microbiota: A Systematic Review and Meta-Analysis

Du¹,

Chen²,

Cheng³

et al. 2022

Dig Dis

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Background: Although indications for evaluation and treatment of Helicobacter pylori (H. pylori) infection are broadening to include primary prevention for gastric adenocarcinoma, potential adverse effects on gut microbiota have been raised. We performed a systematic review and meta-analysis to evaluate the effects of H. pylori therapy on gut microbiota. Methods: PubMed, EMBASE, Cochrane Library and Web of Science (to 4/2021) were searched for studies quantitatively evaluating microbiota before and after H. pylori therapy. Meta-analysis was performed to assess early (<1 year) and long-term (≥1 year) effects on gut microbiota after H. pylori treatment. Subgroup analysis evaluating the effects of H. pylori therapy with addition of probiotics on gut microbiota was also performed. Results: Thirty studies (N=1,218) met the criteria. Early after H. pylori therapy, intestinal microbial diversity was reduced in nearly all studies. At the genus level, reduction in the abundance of Enterococcus, while increase in Lactobacillus, Bifidobacterium, and Bacteroides counts were observed. However, Lactobacillus, Bifidobacterium, Bacteroides, and Enterococcus counts remained stable in patients who received probiotics with H. pylori therapy. At the phylum level, the relative abundance of Actinobacteria and Firmicutes increased after treatment. At ≥1 year, intestinal microbial diversity normalized in six of seven studies. No differences in the relative abundance of Actinobacteria, Firmicute, Bacteroidetes, and Proteobacteria were observed ≥1 year after therapy. Conclusion: The impact of H. pylori therapy on gut microbiota appears transient with early changes largely resolving after one year. Probiotics may reduce the early impact of H. pylori therapy on gut microbiota.

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Section: Discussionsupporting

confidence: 85%

Effects of Helicobacter pylori Therapy on Gut Microbiota: A Systematic Review and Meta-Analysis

Du¹,

Chen²,

Cheng³

et al. 2022

Dig Dis

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“…The benefit of the addition of probiotics in anti- H. pylori regimens could restore the alterations of gastrointestinal microbiota induced by antibiotics or proton pomp inhibitors in the regimens. Multiple studies have investigated the effects of probiotics on gastric[ 13 - 15 ], gastrointestinal[ 16 ], and gut[ 17 - 20 ] microbiota. Well-known probiotic microorganisms include various species of Bifidobacterium (B .…”

Section: Introductionmentioning

confidence: 99%

Probiotics and autoprobiotics for treatment of Helicobacter pylori infection

Baryshnikova,

Ilina,

Ermolenko

et al. 2023

World J Clin Cases

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Inflammatory myofibroblastic tumor (IMT) of the biliary tract is rare, and often difficult to diagnose or to distinguish from other tumors due to its atypical clinical presentation and nonspecific radiological features. Histologically, IMTs are (myo)fibroblastic neoplasms with a prominent inflammatory infiltrate. They are characterized by receptor tyrosine kinase gene rearrangements, most often involving an anaplastic lymphoma kinase (ALK ) translocation. The final diagnosis of IMT depends on histopathology and immunohistochemical examination. In this manuscript, we provide a clinical and morphomolecular overview of IMT and the difficulties that may arise in using immunohistochemical and molecular techniques in diagnosing IMT.

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Observation on the therapeutic effect of probiotics on early oral feeding in the treatment of severe acute pancreatitis

Zhao,

Zhang,

Wang

et al. 2024

Front. Med.

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ObjectivesTo evaluate the clinical efficacy of probiotics and early oral feeding in patients with severe acute pancreatitis.MethodsA prospective, randomized, controlled trial was conducted involving 66 patients, who were randomly divided into a control group (n = 32) receiving standard enteral nutrition and an observation group (n = 34) receiving additional Bifidobacterium quadruplex live bacterial tablets. Serum inflammatory markers, including white blood cells (WBC), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP), were measured on days 1, 3, and 7 post-admission. Abdominal pain scores, the computed tomography severity index (CTSI), and the Bedside Index for Severity in Acute Pancreatitis (BISAP) scores were also assessed. Additionally, defecation time and the total duration of hospitalization were compared between the two groups.ResultsInflammatory markers declined in all groups by the third day post-admission, with the observation group exhibiting a significantly greater reduction compared to the control group (p < 0.05). Similarly, from the first day to the third day, both groups experienced a decrease in abdominal pain scores, CTSI, and BISAP scores, with the observation group showing a significantly more pronounced decrease in BISAP scores compared to the control group (p < 0.05). By the seventh day of admission, inflammatory markers continued to decline in all groups compared to the third day, except for TNF-α levels, and the observation group demonstrated a significantly greater decrease compared to the control group (p < 0.05). Abdominal pain scores, CTSI, and BISAP scores also decreased further in both groups compared to the third day, with the observation group again showing a significantly greater improvement than the control group (p < 0.05). Additionally, the observation group had a significantly shorter time to bowel movement resumption (38.23 ± 2.31 h vs. 43.43 ± 2.75 h, p = 0.013) and total hospital stay compared to the control group (10.97 ± 0.35 days vs. 13.40 ± 0.50 days, p < 0.001).ConclusionEarly oral ingestion combined with probiotics can reduce the levels of inflammatory factors, improve abdominal pain symptoms, alleviate pancreatic edema and shorten defecation time and hospital stay in patients with severe acute pancreatitis.

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Effects of probiotics on gastric microbiota and its precombination with quadruple regimen for Helicobacter pylori eradication

Cited by 3 publications

References 47 publications

Effects of <b><i>Helicobacter pylori</i></b> Therapy on Gut Microbiota: A Systematic Review and Meta-Analysis

Effects of <b><i>Helicobacter pylori</i></b> Therapy on Gut Microbiota: A Systematic Review and Meta-Analysis

Probiotics and autoprobiotics for treatment of Helicobacter pylori infection

Observation on the therapeutic effect of probiotics on early oral feeding in the treatment of severe acute pancreatitis

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