“…Thus, through the use Response Surface Method (RSM), one can optimize all the major parameters and eliminate the limitations of oneparameter optimization (Choudhury and El-Baradie, 1999). RSM has been used in various fields such as machining techniques (Choudhury and El-Baradie, 1999), chemical reactions (Sultania et al, 2011;Setiabudi et al, 2013) enzyme and catalytic reactions (Hosseinpour et al, 2011;Thouchprasitchai et al, 2011;Yüksel and Yeşilçubuk, 2012) and with recent broader application extended to the optimization of water and water treatment processes (Güven et al, 2008;Körbahti and Tanyolaç, 2008;Trinh and Kang, 2011;Kumar and Pal, 2012;Yuliwati et al, 2012), in biochemistry (Wang et al, 2012) toxicology studies (Carter et al, 1985;Kiran and Thanasekaran, 2011;Jeong et al, 2012) and in biotechnology for studying biodegradation of phenol (Sheeja and Murugesan, 2002). However, a limited number of studies (Jo et al, 2008;Jin et al, 2013) were reported on the optimization of BTEX's removal efficiency.…”