Effects of progressive resistance training and weight loss versus weight loss alone on inflammatory and endothelial biomarkers in older adults with type 2 diabetes

Miller, Eliza G.; Sethi, Parneet; Nowson, Caryl; Dunstan, David W.; Daly, Robin M.

doi:10.1007/s00421-017-3657-2

Cited by 32 publications

(23 citation statements)

References 54 publications

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“…Briefly, taking higher dose of vitamin D may be required to affect diabetes risk and control high levels of inflammatory factors in patients with T2D and vitamin D deficiency [1]. Consistent with that, Miller, et al [29] reported that in diabetic and overweight elderly patients participating in resistance training, 3 times a week for 12 weeks, some inflammatory markers significantly improved.…”

Section: Discussionmentioning

confidence: 84%

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Anti-inflammatory effects of vitamin D and resistance training in men with type 2 diabetes mellitus and vitamin D deficiency: a randomized, double-blinded, placebo-controlled clinical trial

Dadrass

Salamat

Hamidi

et al. 2019

J Diabetes Metab Disord

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Objectives The present study aimed to investigate the anti-inflammatory effects of vitamin D and resistance training in men with type 2 diabetes mellitus and vitamin D deficiency. Design This study was a randomized, placebo-controlled, double-blinded clinical trial. Trial registration code: IRCT20190204042621N1 Participants Forty-eight patients with type 2 diabetes aged 40-65 (from a total of 52 volunteers in Ardabil diabetes clinic) were randomly assigned to either the vitamin D supplementation with resistance training group (VD + RT: n = 12), the resistance training group (RT: n = 12), the vitamin D supplementation group (VD: n = 12), or the control group (CON: n = 12). Intervention The subjects in VD group took vitamin D supplements at 50000 IU per 2 weeks for 3 months; the subjects in RT group exercised 3 times per week for 12 weeks; and the subjects in VD + RT group participated in both treatments. Subjects in CON group were asked to maintain normal daily life pattern for the duration of the study. Measurements Serum Interleukin-6 (IL-6), Tumor Necrosis Factor-alpha (TNF-α) and C-reactive protein (CRP) levels were determined at pre and post-test and the data were compared among the four groups and between two tests (4 × 2) using two-way ANOVA with repeated measures. Results IL-6 decreased significantly (P = 0.001) in all groups (VD + RT = %-71.73, RT = %-65.85, VD = %-61.70). TNF-α decreased significantly (P = 0.001) in VD + RT (%-44.90) and RT (%-40) groups. CRP showed no significant change in any group (P > 0.05). Conclusion Results demonstrated that vitamin D supplementation in addition to resistance training had positive effects on some inflammatory markers in T2D and vitamin D deficient men. Vitamin D supplementation was especially effective when it was complemented with exercise training.

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Section: Discussionmentioning

confidence: 84%

“…As previously mentioned, both vitamin D [4] and physical activity [29] are believed to affect systemic inflammation in diabetic people. It has been reported that increased serum 25(OH) D levels in diabetics improves inflammatory markers and glycemic control [28].…”

Section: Discussionmentioning

confidence: 92%

Anti-inflammatory effects of vitamin D and resistance training in men with type 2 diabetes mellitus and vitamin D deficiency: a randomized, double-blinded, placebo-controlled clinical trial

Dadrass

Salamat

Hamidi

et al. 2019

J Diabetes Metab Disord

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“…After screening the titles of the rest of the 2421 articles, 288 were selected for the abstract and full-text assessment, and 37 of them were included in this study, which met the required inclusion criteria. Out of 37, 13 articles were excluded with the following reasons: control group was not diabetic in three trials [23,24,25], data presented as mean difference or no comparable diabetic control trial in seven studies [13,15,23,26,27,28,29], two articles with insufficient exercise intensity details [30,31] and same data used in different articles [32]. Finally, 24 articles [19,20,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54] were included in the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

Resistance Exercise Intensity is Correlated with Attenuation of HbA1c and Insulin in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis

Liu

Chen³

et al. 2019

IJERPH

131

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We investigated the influence of resistance exercise (RE) with different intensities on HbA1c, insulin and blood glucose levels in patients with type 2 diabetes (T2D). Diabetes trials that compared RE group with a control were included in meta-analysis. Exercise intensities were categorized into low-to-moderate-intensity and high-intensity subgroups. Intensity effect on glycemic control was determined by meta-regression analysis, and risk-of-bias was assessed using Cochrane Collaboration tool. 24 trials met the inclusion criteria, comprised of 962 patients of exercise (n = 491) and control (n = 471). Meta-regression analysis showed decreased HbA1c (p = 0.006) and insulin (p = 0.015) after RE was correlated with intensity. Subgroup analysis revealed decreased HbA1c was greater with high intensity (−0.61; 95% CI −0.90, −0.33) than low-to-moderate intensity (−0.23; 95% CI −0.41, −0.05). Insulin levels were significantly decreased only with high intensity (−4.60; 95% CI −7.53, −1.67), not with low-to-moderate intensity (0.07; 95% CI −3.28, 3.42). Notably, values between the subgroups were statistically significant for both HbA1c (p = 0.03) and insulin (p = 0.04), indicative of profound benefits of high-intensity RE. Pooled outcomes of 15 trials showed only a decreased trend in blood glucose with RE (p = 0.09), and this tendency was not associated with intensity. Our meta-analysis provides additional evidence that high-intensity RE has greater beneficial effects than low-to-moderate-intensity in attenuation of HbA1c and insulin in T2D patients.

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“…Mokhtarzade et al reported that leptin and tumor necrosis factor (TNF)-α levels significantly decreased subsequent to aerobic interval training [24]. Miller et al reported that serum adiponectin levels were increased, and serum interleukin 10 and TNF-α levels were decreased in a high-intensity progressive resistance training with moderate weight loss group, compared to the weight loss group, in older overweight adults with type 2 diabetes after 12 months [25]. This shows that long-term participation in exercise training, irrespective of change in weight, can improve certain inflammatory markers.…”

Section: Discussionmentioning

confidence: 99%

Effect of a 12-Week Aerobic Exercise Training on Serum Fetuin-A and Adipocytokine Levels in Type 2 Diabetes

Zhang

Liu

Teng

et al. 2017

Exp Clin Endocrinol Diabetes

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Effects of progressive resistance training and weight loss versus weight loss alone on inflammatory and endothelial biomarkers in older adults with type 2 diabetes

Abstract: Long-term participation in PRT, independent of change in weight, can result in some improvements in certain inflammatory markers in older overweight adults with type 2 diabetes.

Cited by 32 publications

References 54 publications

Anti-inflammatory effects of vitamin D and resistance training in men with type 2 diabetes mellitus and vitamin D deficiency: a randomized, double-blinded, placebo-controlled clinical trial

Anti-inflammatory effects of vitamin D and resistance training in men with type 2 diabetes mellitus and vitamin D deficiency: a randomized, double-blinded, placebo-controlled clinical trial

Resistance Exercise Intensity is Correlated with Attenuation of HbA1c and Insulin in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis

Effect of a 12-Week Aerobic Exercise Training on Serum Fetuin-A and Adipocytokine Levels in Type 2 Diabetes

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