Effect of a 12-Week Aerobic Exercise Training on Serum Fetuin-A and Adipocytokine Levels in Type 2 Diabetes

Zhang, Lingyun; Liu, Tao; Teng, Yaqin; Yao, Xiaoyan; Zhao, Tiantian; Lin, Liangyan; Jin, Qingsong; Jin, Yongjun

doi:10.1055/s-0043-115904

Cited by 27 publications

(31 citation statements)

References 32 publications

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“…A recent meta-analysis indicated that exercise, particularly aerobic exercise, significantly increased the ADP levels compared to no exercise as well as control in overweight and obese individuals [68], consistent with the finding in T2DM [69]. However, some studies is contrary to the results presented before suggested that the plasma ADP levels were not altered after 12 weeks' combined training in overweight and obese children [70].…”

Section: Adp and Exercisesupporting

confidence: 59%

Physical Exercise as Therapy for Type 2 Diabetes Mellitus: From Mechanism to Orientation

Yang

et al. 2019

Ann Nutr Metab

110

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Background: Exercise therapy plays an important role in the prevention and treatment of type 2 diabetes (T2DM). The mechanism of exercise therapy in the improvement of glycolipid metabolism of T2DM is very complex and not completely clear. Summary: Exercise training improves the whole body metabolic health in patients with T2DM, leading to an increase in glycolipid uptake and utilization, improved insulin sensitivity, optimized body mass index, and modulated DNA methylation, etc. Recent findings support that some cytokines such as irisin, osteocalcin, and adiponectin are closely related to exercise and metabolic diseases. This study briefly reviews the physiological mechanisms of exercise therapy in diabetes and the potential role of these cytokines in exercise. Key Messages: More high-quality, targeted, randomized controlled studies are needed urgently, from mechanism study to treatment direction, to provide a more theoretical basis for exercise therapy and to explore new therapeutic targets for diabetes.

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Section: Adp and Exercisesupporting

confidence: 59%

Physical Exercise as Therapy for Type 2 Diabetes Mellitus: From Mechanism to Orientation

Yang

et al. 2019

Ann Nutr Metab

110

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“…Fourthly, some other potential confounders, such as eating habits, alcohol consumption and exercise, have not been collected in this study, which may have moderating effects on the relationship between F/A ratio and MS. Specifically, calorie restriction and exercise can result in decreased fetuin-A levels and increased adiponectin expressions [29,30], and moderate alcohol consumption has been proven to be inversely associated with fetuin-A in men [31].…”

Section: Discussionmentioning

confidence: 99%

Fetuin-a to adiponectin ratio is a sensitive indicator for evaluating metabolic syndrome in the elderly

et al. 2020

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Background: Fetuin-A and adiponectin present significant associations, supported by recent evidence, with metabolic syndrome (MS) featuring hyperglycemia, central obesity and insulin resistance as the main components, but their biological functions are opposite. The aim of this study was to verify whether fetuin-A/adiponectin ratio (F/A ratio) is a more sensitive indicator for evaluation of MS than either fetuin-A or adiponectin. Methods: In this cross-sectional study, 465 elderly subjects were selected from the physical examination database. Serum levels of fetuin-A and adiponectin were measured using an enzyme-linked immunosorbent assay (ELISA) method. Spearman's rank correlation coefficient, linear regression and logistic regression analysis were adopted to estimate the correlations of fetuin-A, adiponectin and F/A ratio with MS and its components, and receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive values of the aforesaid indices. Results: Compared with fetuin-A or adiponectin, F/A ratio was significantly associated with all the components of MS, and this correlation was significant even after adjusting potential confounding factors (P < 0.05). Logistic regression analysis indicated that F/A ratio presented a stronger correlation with incident MS (adjusted OR: 1.466; 95% CI: 1.189-1.808) than fetuin-A (adjusted OR: 1.100; 95% CI: 1.020-1.186) and adiponectin (adjusted OR: 0.760; 95% CI: 0.664-0.871) alone. ROC analysis revealed that F/A ratio achieved a larger area under curve (AUC) than fetuin-A and adiponectin, with their AUC values of 0.755, 0.709 and 0.708, respectively. Conclusion: F/A ratio is a more sensitive index for evaluating MS than either fetuin-A or adiponectin in the elderly.

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“…A clinical study confirmed a positive correlation between circulating fetuin-A concentrations and insulin resistance ( 114 ). Exercise training including aerobic exercise using an ergometer or walking generally reduces ( 115 – 117 ) or tends to reduce ( 118 , 119 ) circulating fetuin-A in subjects with type 2 diabetes and NAFLD. Improvements in hepatic insulin resistance correlated with decreasing levels of blood fetuin-A ( 116 ).…”

Section: Mechanisms By Which Exercise Improves Nafld; a Narrative Revmentioning

confidence: 99%

Therapeutic Approaches to Nonalcoholic Fatty Liver Disease: Exercise Intervention and Related Mechanisms

et al. 2018

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Exercise training ameliorates nonalcoholic fatty liver disease (NAFLD) as well as obesity and metabolic syndrome. Although it is difficult to eliminate the effects of body weight reduction and increased energy expenditure—some pleiotropic effects of exercise training—a number of studies involving either aerobic exercise training or resistance training programs showed ameliorations in NAFLD that are independent of the improvements in obesity and insulin resistance. In vivo studies have identified effects of exercise training on the liver, which may help to explain the “direct” or “independent” effect of exercise training on NAFLD. Exercise training increases peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) expression, improves mitochondrial function and leads to reduced hepatic steatosis, inflammation, fibrosis, and tumor genesis. Crosstalk between the liver and adipose tissue, skeletal muscle and the microbiome is also a possible mechanism for the effect of exercise training on NAFLD. Although numerous studies have reported benefits of exercise training on NAFLD, the optimal duration and intensity of exercise for the prevention or treatment of NAFLD have not been established. Maintaining adherence of patients with NAFLD to exercise training regimes is another issue to be resolved. The use of comprehensive analytical approaches to identify biomarkers such as hepatokines that specifically reflect the effect of exercise training on liver functions might help to monitor the effect of exercise on NAFLD, and thereby improve adherence of these patients to exercise training. Exercise training is a robust approach for alleviating the pathogenesis of NAFLD, although further clinical and experimental studies are required.

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Effect of a 12-Week Aerobic Exercise Training on Serum Fetuin-A and Adipocytokine Levels in Type 2 Diabetes

Abstract: Aerobic exercise significantly decreased serum fetuin-A levels in type 2 diabetes mellitus, which can be attributed to weight loss and related to increased adiponectin levels.

Cited by 27 publications

References 32 publications

Physical Exercise as Therapy for Type 2 Diabetes Mellitus: From Mechanism to Orientation

Physical Exercise as Therapy for Type 2 Diabetes Mellitus: From Mechanism to Orientation

Fetuin-a to adiponectin ratio is a sensitive indicator for evaluating metabolic syndrome in the elderly

Therapeutic Approaches to Nonalcoholic Fatty Liver Disease: Exercise Intervention and Related Mechanisms

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