Effects of prostacyclin during cardiopulmonary bypass in men on plasma levels of β-thromboglobulin, platelet factor 4, thromboxane B2, 6-keto-prostaglandin F1α and heparin

Ditter, H; Heinrich, D.; Fr, Matthias; Sellmann-Richter, R.; Wagner, W.; Hehrlein, F. W.

doi:10.1016/0049-3848(83)90092-0

Cited by 18 publications

(4 citation statements)

References 31 publications

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“…Studies such as these which measure blood levels rather than directly assessing kinetics and/or production and release of prostaglandins do not provide definitive proof that the vascular endothelium is chronically injured and constantly releasing small quantities of PGI2 into the circulation. (22), and this mechanical process might be expected to elicit PGI2 release (3,15) and ultimately result in intimal proliferation and arterial narrowing and/or occlusion (16).…”

Section: Discussionmentioning

confidence: 99%

Plasma Levels of Platelet and Vascular Prostaglandin Derivatives in Children with Sickle Cell Anaemia

Buchanan

Holtkamp

1985

Thromb Haemost

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SummaryPlatelet and vascular endothelial prostaglandin derivatives were measured by radioimmunoassay in the plasma of 39 children with homozygous sickle cell anaemia and 27 control subjects. The levels of both thromboxane B2 and 6-keto-PGF1α, the stable endproducts of platelet and vascular prostaglandin metabolism, were significantly (p <0.001) greater in sickle cell anaemia plasma than in the plasma of the controls. There were no differences in levels of either 6-keto-PGF1α or thromboxane B2 between steady state and vaso-occlusive crisis in the sickle cell patients. Injury to the endothelial lining of blood vessels may occur in sickle cell anaemia as a consequence of contact with the abnormal erythrocytes.

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Section: Discussionmentioning

confidence: 99%

Plasma Levels of Platelet and Vascular Prostaglandin Derivatives in Children with Sickle Cell Anaemia

Buchanan

Holtkamp

1985

Thromb Haemost

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“…Nagaoka [16] reported therapeutic interventions in platelet release reaction during CPB, including the use of antiaggregatory vasodilator prostacyclin [17,18], and use of the platelet activation inhibitor aprotinin [19]. The use of PGl 2 -infusion during CPB remains controversial.…”

Section: Discussionmentioning

confidence: 99%

“…The use of PGl 2 -infusion during CPB remains controversial. Some investigators [17,18] have suggested that PGl 2 -treated patients had less platelet loss, b-TG, and PF 4 production than those of untreated patients indicating the protective effects of prostacyclin infusion on platelets in open heart surgery. In contrast, others [19] have not only failed to find any beneficial effect of prostacyclin on platelet count or function, but have also found some adverse results.…”

Section: Discussionmentioning

confidence: 99%

Elastase Release Following Myocardial Ischemia during Extracorporeal Circulation (ECC) - Marker of Ongoing Systemic Inflammation?

Boeken

Feindt²,

Schulte³

et al. 2002

Thorac cardiovasc Surg

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Our results indicate that CPB initiates an elastase release that can be suppressed by prostacyclin. Increased intraoperative elastase levels in patients with PPS show that elastase may be an indicator of ongoing systemic inflammation, possibly causing complications due to a hypercoagulatory state. Myocardial ischemia seems to be one reason for this elastase release. It can be speculated that early PGl2-infusion could be a therapeutic option in inflammatory diseases caused by ECC.

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“…On the other hand, vasodilator substances would reduce vasodilatory reserve at normal pressure, thus also limiting the ability of the RC to maintain flow as RCP is reduced. These vasoactive substances have not been completely characterized but include vasoconstrictory thromboxane (7,25) and vasodilatory prostacyclin (8,23,25). Accordingly, some investigators have administered ibuprofen in studies of LC autoregulation (3,5,21).…”

Section: H173mentioning

confidence: 99%

Right coronary autoregulation in conscious, chronically instrumented dogs

Bian

Williams

Gwirtz

et al. 1998

American Journal of Physiology-Heart and Circulatory Physiology

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Right coronary (RC) autoregulation and right ventricular (RV) function were assessed in conscious dogs, chronically instrumented to measure RC flow and RC pressure (RCP) as a hydraulic occluder on the RC was inflated. Dogs were then anesthetized, and RC autoregulation and RV function were again assessed. In the conscious state, moderate RC autoregulation was present with closed loop gains (Gc) of 0.59–0.27 as RCP was reduced from 100 to 40 mmHg. In the anesthetized state, Gc was not significantly less than in the conscious state at RCP >50 mmHg. The range and potency of RV autoregulation were greater in both groups than for previously reported findings in anesthetized dogs with RC perfused by an extracorporeal system. RV contractile function was well maintained in conscious and anesthetized dogs at RCP >45 mmHg. We conclude the following: 1) modest RC autoregulation is present in the conscious dog, 2) anesthesia limits the range but not the degree of RC autoregulation, 3) extracorporeal perfusion systems appear to depress RC autoregulation, and 4) RV contractile function remains constant in both conscious and anesthetized dogs until RCP falls below 50 mmHg.

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Effects of prostacyclin during cardiopulmonary bypass in men on plasma levels of β-thromboglobulin, platelet factor 4, thromboxane B2, 6-keto-prostaglandin F1α and heparin

Cited by 18 publications

References 31 publications

Plasma Levels of Platelet and Vascular Prostaglandin Derivatives in Children with Sickle Cell Anaemia

Plasma Levels of Platelet and Vascular Prostaglandin Derivatives in Children with Sickle Cell Anaemia

Elastase Release Following Myocardial Ischemia during Extracorporeal Circulation (ECC) - Marker of Ongoing Systemic Inflammation?

Right coronary autoregulation in conscious, chronically instrumented dogs

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