Effects of Prostaglandin E₂ and Cholinergic Drugs on Intraocular Pressure

Abstract

Effects of prostaglandin E₂ (PGE₂) and cholinergic drugs on intraocular pressure (IOP) have been studied in the rabbit. PGE₂ injected intracamerally in a dose of 5 µg produced a long-lasting increase in IOP. Topical pretreatment with carbachol, physostigmine and pilo-carpine abolished the rise of IOP after the intracameral injection of PGE₂. When the IOP had already been increased by PGE₂ topical application of pilocarpine and physostigmine did not change it. Carbachol even potentiated the pressor effect of PGE₂.