Effects of pyrethroid insecticides on hypothalamic-pituitary-gonadal axis: A reproductive health perspective

Ye, Xiaoqing; Liu, Jing

doi:10.1016/j.envpol.2018.11.031

Cited by 73 publications

(28 citation statements)

References 124 publications

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“…E. Kilian et al. focused on the effect of deltamethrin and phytoestrogens on rat reproductive parameters, and the results suggested that they both influenced sperm count and testis mass; the authors hypothesized that deltamethrin may have estrogenic effects ( 13 , 14 ).…”

Section: Introductionmentioning

confidence: 99%

Pyrethroids Toxicity to Male Reproductive System and Offspring as a Function of Oxidative Stress Induction: Rodent Studies

Zhang

Ren

et al. 2021

Front. Endocrinol.

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Pyrethroids may be related to male reproductive system damage. However, the results of many previous studies are contradictory and uncertain. Therefore, a systematic review and a meta-analysis were performed to assess the relationship between pyrethroid exposure and male reproductive system damage. A total of 72 articles were identified, among which 57 were selected for meta-analysis, and 15 were selected for qualitative analysis. Pyrethroid exposure affected sperm count (SMD= -2.0424; 95% CI, -2.4699 to -1.6149), sperm motility (SMD=-3.606; 95% CI, -4.5172 to -2.6948), sperm morphology (SMD=2.686; 95% CI, 1.9744 to 3.3976), testis weight (SMD=-1.1591; 95% CI, -1.6145 to -0.7038), epididymal weight (SMD=-1.1576; 95% CI, -1.7455 to -0.5697), and serum testosterone level (SMD=-1.9194; 95% CI, -2.4589 to -1.3798) in the studies of rats. We found that gestational and lactational exposure to pyrethroids can reduce sperm count (SMD=1.8469; 95% CI, -2.9010 to -0.7927), sperm motility (SMD=-2.7151; 95% CI, -3.9574 to -1.4728), testis weight (SMD=-1.4361; 95% CI, -1.8873 to -0.9848), and epididymal weight (SMD=-0.6639; 95% CI, -0.9544 to -0.3733) of F1 offspring. Exposure to pyrethroids can increase malondialdehyde (SMD=3.3451; 95% CI 1.9914 to 4.6988) oxide in testes and can reduce the activities of glutathione (SMD=-2.075; 95% CI -3.0651 to -1.0848), superoxide dismutase (SMD=-2.4856; 95% CI -3.9612 to -1.0100), and catalase (SMD=-2.7564; 95% CI -3.9788 to -1.5340). Pyrethroid exposure and oxidative stress could damage male sperm quality. Gestational and lactational pyrethroid exposure affects the reproductive system of F1 offspring.

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Section: Introductionmentioning

confidence: 99%

Pyrethroids Toxicity to Male Reproductive System and Offspring as a Function of Oxidative Stress Induction: Rodent Studies

Zhang

Ren

et al. 2021

Front. Endocrinol.

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“…Odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of POI in association with TEQs levels were calculated by unconditional logistic regression models. The covariates included age, BMI, parity, history of breast-feeding, age at menarche, smoking, alcohol intake, education and annual household income [5], [6]. POPs concentration variables that were detected in >40% samples were subjected to principal components analysis (PCA) to produce a few number of summary PCA predictor variables.…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

Supporting dataset and methods for serum concentrations of selected persistent organic pollutants measured in women with primary ovarian insufficiency

Pan

Yin

et al. 2019

Data in Brief

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The dataset presented in this article supports “Selected persistent organic pollutants associated with the risk of primary ovarian insufficiency in women” (Pan et al., 2019). The supplementary data were as follows: (1) Detailed information regarding pretreatment methods, instrumental analysis and methods validation of quantification of serum concentrations of persistent organic pollutants (POPs). (2) The total dioxin equivalents (TEQs) levels of dioxin-like PCBs (DL-PCBs) in primary ovarian insufficiency (POI) cases and controls, as well as the association of TEQ levels with the risk of POI. (3) The results of principal components analyses (PCA) about 20 POPs that were detected in >40% samples.

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“…gonadotropin releasing hormone (GnRH) levels. There are few studies demonstrating that gonadotropic cells' function and expression of LH and FSH coding genes have changed with pyrethroids exposure [20]. Dohlman et al [21] reported that permethrin caused reduction in progesterone levels in beef heifers.…”

Section: Hormonal System Disruptionmentioning

confidence: 99%

Reproductive Toxicity of Insecticides

Kara¹,

Öztaş²

2021

Animal Reproduction in Veterinary Medicine

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Pesticides include several classes such as insecticides, herbicides, fungicides, and have widespread usage in agriculture. Different type of pesticides and their combinations affect dairy animals through their lifetime and the livestock industry. Under chronic exposure conditions, hormonal and cellular systems of animals, which play a role in reproduction, are affected dramatically. Some of the insecticides act as endocrine disruptors and impair reproductive hormone metabolic pathways via the hypothalamic-pituitary-gonadal (HPG) axis. Additionally, insecticides could have harmful effects on reproductive organs that may cause infertility. The aim of this chapter is review the toxic effects of insecticides on animal reproductive system focusing on molecular mechanisms.

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Effects of pyrethroid insecticides on hypothalamic-pituitary-gonadal axis: A reproductive health perspective

Cited by 73 publications

References 124 publications

Pyrethroids Toxicity to Male Reproductive System and Offspring as a Function of Oxidative Stress Induction: Rodent Studies

Pyrethroids Toxicity to Male Reproductive System and Offspring as a Function of Oxidative Stress Induction: Rodent Studies

Supporting dataset and methods for serum concentrations of selected persistent organic pollutants measured in women with primary ovarian insufficiency

Reproductive Toxicity of Insecticides

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