Effects of pyridoxine of male fertility.

Tsutsumi, Shunsuke; Tanaka, Toshimitsu; Gotoh, Kohsei; Akiyama, Masashi

doi:10.2131/jts.20.351

Cited by 10 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The clinical signs of toxicity after 200-300 mg vitamin B 6 /kg body weight regress within 3 months after the withdrawal of these massive doses, but sensory nerve conduction velocity, which decreases during the development of the neuropathy, does not recover fully (Schaeppi & Krinke, 1982). At even higher doses (500 or 1000 mg/kg body weight by intraperitoneal injection) pyridoxine has been shown to cause a decrease in testis weight, histological changes in the testes and reduced spermatogenesis and sperm motility (Mori et al 1992;Tsutsumi et al 1995). The relevance of this, in terms of either the route of administration or the massive doses involved, to high oral intakes of the vitamin in human beings is doubtful.…”

Section: Toxicity Of Vitamin Bmentioning

confidence: 99%

Non-nutritional uses of vitamin B₆

Bender

1999

Br J Nutr

102

View full text Add to dashboard Cite

Vitamin B6is a water-soluble vitamin, and is readily metabolized and excreted, so it has generally been assumed to have negligible toxicity, although at very high levels of intake it can cause peripheral nerve damage. Nutritional deficiency disease is extremely rare, although a significant proportion of the population shows biochemical evidence of inadequate status, despite apparently adequate levels of intake. The vitamin has been used to treat a wide variety of conditions, which may or may not be related to inadequate intake. In some conditions use of vitamin B6supplements has been purely empirical; in other conditions there is a reasonable physiological or metabolic mechanism to explain why supplements of the vitamin many times greater than average requirements may have therapeutic uses. However, even in such conditions there is little evidence of efficacy from properly conducted controlled trials.

show abstract

Section: Toxicity Of Vitamin Bmentioning

confidence: 99%

Non-nutritional uses of vitamin B₆

Bender

1999

Br J Nutr

102

View full text Add to dashboard Cite

show abstract

“…e e i x j m x 1 i j (12) where m represents the number of samples; y i and yî are actual and predicted values of the ith sample, respectively; and f(z i ) represents the output of the ith neuron. S6).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…For instance, pyridoxine at 0.5 or 1 g/kg is associated with a decrease in the formation and motility of sperms. Also, the weight and the histology of the testes can be changed. , It is important to note that the normal daily allowance of vitamin B 6 for adults is approximately between 1 and 2 mg . Of note, the derivatives of vitamin B 6 include pyridoxine, pyridoxal, pyridoxamine, pyridoxal 5′-phosphate, and pyridoxamine 5′-phosphate. , Pyridoxine and phosphorylated derivatives are considered the main dietary forms of VB6Ds .…”

Section: Introductionmentioning

confidence: 99%

Deep Learning-Based Sensor Array: 3D Fluorescence Spectra of Gold Nanoclusters for Qualitative and Quantitative Analysis of Vitamin B₆ Derivatives

Noreldeen

Huang

et al. 2022

Anal. Chem.

View full text Add to dashboard Cite

Vitamin B6 derivatives (VB6Ds) are of great importance for all living organisms to complete their physiological processes. However, their excess in the body can cause serious problems. What is more, the qualitative and quantitative analysis of different VB6Ds may present significant challenges due to the high similarity of their chemical structures. Also, the transfer of deep learning model from one task to a similar task needs to be present more in the fluorescence-based biosensor. Therefore, to address these problems, two deep learning models based on the intrinsic fingerprint of 3D fluorescence spectra have been developed to identify five VB6Ds. The accuracy ranges of a deep neural network (DNN) and a convolutional neural network (CNN) were 94.44–97.77% and 97.77–100%, respectively. After that, the developed models were transferred for quantitative analysis of the selected VB6Ds at a broad concentration range (1–100 μM). The determination coefficient (R 2) values of the test set for DNN and CNN were 93.28 and 97.01%, respectively, which also represents the outperformance of CNN over DNN. Therefore, our approach opens new avenues for qualitative and quantitative sensing of small molecules, which will enrich fields related to deep learning, analytical chemistry, and especially sensor array chemistry.

show abstract

“…An excess-VB6 diet induced neurological damage in an animal experiment (23). It was also reported that the administration of VB6 at 250 or 500 mg/kg BW intraperitoneally induced abnormal spermatogenesis and testis atrophy after 2 or 4 wk of treatment (24,25). On the other hand, Fukuwatari et al reported that a 1% VB6 diet (about 1,400 times the normal level) decreased body weight but did not infl uence testes weight of rats (26).…”

Section: Discussionmentioning

confidence: 97%

The Interactive Effect of Dietary Water-Soluble Vitamin Levels on the Depression of Gonadal Development in Growing Male Rats Kept under Disturbed Daily Rhythm

Hanai

ESASHI

2012

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

230The number of people living under disturbed daily rhythm has been increasing due to the globalization of business and social activities as well as the diversifi cation of the forms of labor. Such irregularities in daily rhythm adversely affect bio-regulatory mechanisms, resulting in an abnormal diurnal rhythm that can impede biological activities structurally and functionally. However, there is currently no source of collected basic data on the nutritional aspects of maintaining or promoting health under the condition of disturbed daily rhythm. The perspective behind this research is as follows: as basic data on the relationship between nutritional status and gonadal development in rats with disturbed daily rhythm accumulate, these data can be used for human research, and fi nally, dietary reference intakes can be compiled for persons living under disturbed daily rhythm.Lighting is one of the key external factors for the formation of daily rhythm. Rats kept under constant darkness develop disturbances in their feeding and motoractivity rhythms, and suffer from altered rhythms of hormone secretion and enzyme activity (1, 2). Esashi et al. (3,4) have reported that rats kept under constant darkness showed depressed gonadal development and a decreased delivery rate. The depression of gonadal development in these rats was accelerated by a low-protein diet (4). These fi ndings indicate that the gonads have high sensitivity to constant darkness and nutrients.In previous papers, we have reported the effects on rat gonadal development of protein, methionine, vitamins, minerals and oil (5), minerals (6), amino acids, an AIN-76 diet and an AIN-93G diet (7), the interaction between protein and vitamins (8), water-and fat-soluble vitamins (9) and each of the fat-soluble vitamins (10). We have demonstrated that a high level (three times the normal (AIN-93G)) of water-soluble vitamin and a low level (1/3.3 of normal) of fat-soluble vitamin diet mitigated the depression of gonadal development in rats kept under constant darkness (9). Therefore, as a next step, we attempted to clarify the effects on gonadal development of nine kinds of water-soluble vitamins under a diet with a low level of fat-soluble vitamins. In this experiment, the content of each water-soluble vitamin was normal or six times the normal content. This study was divided into two experiments, because a single experiment to test all nine water-soluble vitamins couldn't be done. In the fi rst experiment (Ex. 1) we examined seven water-soluble vitamins, and in the second experiment (Ex. 2) we examined two water-soluble vitamins. Experiment 1 was carried out using an orthogonal array (11, 12), which is the experimental design we applied in previous studies (5-7, 10), and Ex. Summary The purpose of this study was to clarify the effects of nutrients on the gonadal development of male rats kept under constant darkness as a model of disturbed daily rhythm. In the present study we examined the effects of nine water-soluble vitamins. We selected 7 water-soluble vitam...

show abstract

Effects of pyridoxine of male fertility.

Cited by 10 publications

References 13 publications

Non-nutritional uses of vitamin B₆

Non-nutritional uses of vitamin B₆

Deep Learning-Based Sensor Array: 3D Fluorescence Spectra of Gold Nanoclusters for Qualitative and Quantitative Analysis of Vitamin B₆ Derivatives

The Interactive Effect of Dietary Water-Soluble Vitamin Levels on the Depression of Gonadal Development in Growing Male Rats Kept under Disturbed Daily Rhythm

Contact Info

Product

Resources

About

Effects of pyridoxine of male fertility.

Cited by 10 publications

References 13 publications

Non-nutritional uses of vitamin B6

Non-nutritional uses of vitamin B6

Deep Learning-Based Sensor Array: 3D Fluorescence Spectra of Gold Nanoclusters for Qualitative and Quantitative Analysis of Vitamin B6 Derivatives

The Interactive Effect of Dietary Water-Soluble Vitamin Levels on the Depression of Gonadal Development in Growing Male Rats Kept under Disturbed Daily Rhythm

Contact Info

Product

Resources

About

Non-nutritional uses of vitamin B₆

Non-nutritional uses of vitamin B₆

Deep Learning-Based Sensor Array: 3D Fluorescence Spectra of Gold Nanoclusters for Qualitative and Quantitative Analysis of Vitamin B₆ Derivatives