Effects of pyruvate-enriched peritoneal dialysis solution on intestinal barrier in peritoneal resuscitation from hemorrhagic shock in rats

Effect of Intraperitoneal Resuscitation With Different Concentrations of Sodium Pyruvate on Intestinal Ischemia Reperfusion Injury in Hemorrhagic Shock Rat

“…Even though we did not observe splanchnic blood flow and survival rate in this study, other studies have already confirmed that the administration of PR using solutions containing pyruvate could significantly improve those indexes (13,14). Compared with lactate-based peritoneal dialysis solution, PR fluid of pyruvate showed significant protective advantages on its protective effect in cells and organs.…”

“…Pyruvate has protective effects on intestinal mucosal ischemia-reperfusion injury (15,21). When administering fluid resuscitation in HS, the addition of PR using pyruvate solution to VR can effectively inhibit the inflammatory response, scavenge oxygen-free radicals, protect the intestinal mucosal barrier, reduce intestinal ischemia-reperfusion injury following resuscitation, and prevent the occurrence of MODS (12)(13)(14). Zakaria et al attributed the beneficial effects of PR to the hypertonicity and the contained glucose of the peritoneal dialysis fluid used (5,6).…”

“…Pyruvate can protect cells and organs (9)(10)(11). In animal experiments, PR using fluid containing pyruvate combined with VR has proven better than normal saline or Lactated Ringer's solution fluid resuscitation and can prevent gut barrier dysfunction and improve survival and prognosis (12,13).…”

Pyruvate Is Superior to Citrate in Oral Rehydration Solution in the Protection of Intestine via Hypoxia‐Inducible Factor‐1 Activation in Rats With Burn Injury

“…This connection may be associated with the improvement of energy metabolism, preservation of IMBF and Na + -K + -ATP activity, and inhibition of oxidative stress. 16,17 Furthermore, pyruvate protection of a ZO-1 regulator protein might be also involved, based on recent experiments showing that pyruvate inhibition of intestinal phosphorylated vasodilator-stimulated phosphoprotein (p-VASP) potentially reversed VASP, a ZO-1 regulatory protein, 34 which may also be HIF-1α dependent. 35 Although there was no detection of the precise causal relationship between pyruvate and activation of HIF-1-EPO signal pathway in the experiment, the present data provide an additional piece of evidence that pyruvate organ protection is closely associated with activation of HIF-1 signaling cascades in the intestine.…”

Application of pulsed arterial resuscitation in a rabbit model of hemorrhagic shock

“…[1][2][3][4][5][6][7] However, while early mortality has been significantly reduced, long-term mortality rate remains high. The main causes of death secondary to hemorrhagic shock are tissue hypoperfusion, major bleeding, and reperfusion injury, which can lead to multiple organ dysfunction syndrome.…”