Effects of quaternization on the morphological stability and antibacterial activity of electrospun poly(DMAEMA-co-AMA) nanofibers

Xu, Jiancai; Wang, Yao; Yang, Yong; Ye, Xiang-Yu; Yao, Ke; Ji, Jian; Xu, Zhi‐Kang

doi:10.1016/j.colsurfb.2015.06.002

Cited by 26 publications

(13 citation statements)

References 47 publications

(69 reference statements)

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Section: Inhibitory Biological Process On Bacteriamentioning

confidence: 99%

“…Triclosan Inhibits the fatty acid synthesis of bacteria [226] Cinnamaldehyde Leads to a depletion of the proton gradient and a subsequent disruption of ATP synthesis or bacteria lysis [227] Ethylene oxide Oxidates the zymoprotein of bacteria inducing its inactivation [227] Chitosan Inhibits the RNA synthesis of bacteria [228,229] Quaternary ammonium salt Disrupts the bacterial cell membrane [230,231] Ciprofloxacin Inhibits the activity of bacterial DNA gyrase [232,233] Quercetin Disrupts the bacterial cell wall and membrane [232] Mupirocin Inhibits the RNA and protein synthesis of bacteria [234] Amoxicillin Prevents the synthesis of the bacterial cell wall [235] Vancomycin Prevents the synthesis of the bacterial cell wall in Gram-positive bacteria [236] (Continued) www.advancedsciencenews.com www.advtherap.com Table 2. Continued.…”

Section: Structural Formula Mechanism Referencementioning

confidence: 99%

“…Similarly, Xu et al utilized benzyl chloride (BC) and p-xylylene dichloride (XDC) to quaternize an electrospun poly(dimethylamino ethyl methacrylate-co-alkyl methacrylates) nanofibrous scaffold by generating surface cations ( Figure 10C). [231] They discovered that the BC-quaternized fibers displayed stronger bactericidal behavior against E. coli and S. aureus than the XDC-quaternized fibers due to the inhibitory effect of crosslinking on the chain mobility of cations, indicating that cation chain mobility was essential for their antiseptic capacity. In conclusion, the high efficacy and availability of antibacterial agents, including biocides and surface topography, functioned as a basis for fabricating electrospun nanofibers with high potential for inhibiting bacteria surface viability.…”

Section: Doxycyclinementioning

confidence: 99%

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Two Sides of Electrospun Fiber in Promoting and Inhibiting Biomedical Processes

Wang

Cui

2020

Advanced Therapeutics

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Electrospinning is a versatile technique for generating ultrathin fibers, which is widely applied in various biomedical applications. The properties and structures of the fibers are specifically engineered to meet the needs of particular applications. The impact of nanofibrous scaffolds on biological processes is related to the promotion or inhibition of specific cell or bioactive substance functions. Here, a novel analysis of the diverse roles of electrospun nanofibrous scaffolds is provided and recent advances in exploiting their binary attributes for applications in biomedicine are summarized. This review initially introduces the development techniques for electrospinning, specifically the engineering of electrospun nanofibers. Then, scaffold applications for cell migration, adhesion, proliferation, and accelerating regeneration in cardiac, nerve, skeletal muscle, bone tissue, and wound healing are presented. Moreover, their inhibitory properties in cancer treatments, antibacterial applications, anti‐adhesion, anti‐scarring, and inhibition of thrombus formation are summarized. Eventually, the potential for future work using multifunctional, electrospun, nanofibrous scaffolds, in order to further inspire the development of scaffolds for biomedical treatments is summarized and discussed.

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Section: Inhibitory Biological Process On Bacteriamentioning

confidence: 99%

Section: Structural Formula Mechanism Referencementioning

confidence: 99%

Section: Doxycyclinementioning

confidence: 99%

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Two Sides of Electrospun Fiber in Promoting and Inhibiting Biomedical Processes

Wang

Cui

2020

Advanced Therapeutics

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“…Hydroxyapatite (HA) is well known as a bioactive ceramic added to many artificial bone tissues and implants for orthopedic surgeries [14][15][16]. Not only polymer/HA composites exhibit the chemical and mechanical stability of natural bones [17,18], but also they can be designed in the form of porous materials that accelerate the circulation of essential biochemical agents such as VD 3 [19]. Given the significant chemical (e.g.…”

Section: Introductionmentioning

confidence: 99%

Effect of HA Nanoparticles on Adsorption of Vitamin D3 on Super-Hydrophobic PA6 Nanofibrous Scaffold

Esfahani

Ghiyasi

2020

Matéria (Rio J.)

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Vitamin D 3 has significant roles in bone growth and the prevention of osteoporotic fractures. The present study investigated the effect of hydroxyapatite nanoparticles decoration onto polyamide-6 nanofibrous scaffold on adsorption behaviour of Vitamin D 3. To synthesize the nanofibrous scaffold, an electrospinning device was used, and the surface of the scaffold was characterized by scanning electron microscopy, energy dispersive spectrometry, Fourier transform infrared spectroscopy, and measurement of the water contact angle. The antibacterial activity test against E. coli and S. aureus bacteria indicated no such activity of pristine and hydroxyapatite decorated scaffold. The results demonstrated that a hydrophobic and high porous scaffold was formed, and hydroxyapatite nanoparticles were distributed inside the polyamide-6 nanofibers homogenously. Results showed that the hydroxyapatite nanoparticles improved the adsorption efficiency of polyamide-6 scaffold. It was found that the amount of adsorbed Vitamin D 3 molecules onto the polyamide-6/HA scaffold was rapid during the first hour of immersion (24.4 ng.cm-3), then declined over the next 3 h, and eventually reached a stable percentage of about 10.3 ng.cm-3. This phenomenon appears to be related to the high adsorption potential of porosities and the hydrophobic nanofibers during the first stage of immersion and non-occupied hydroxyapatite ceramic sites during the final stage of immersion.

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“…Via the electrostatic interactions between the cationic quaternary ammonium group and the negatively-charged bacteria cell membrane, the QAC side chain could disrupt the construction and lead to leakage of cytoplasmic material and cellular lysis. In the past decades, QACs had been covalent modified onto material surfaces by various methods and revealed to be an effective approach for rendering surfaces permanent contact-active antibacterial activity [28,29,30,31,32]. However, few papers have reported surface modification of polyethersulfone (PES) membranes with QACs to improve the antifouling activity and discussed the effect of modification to membrane flux.…”

Section: Introductionmentioning

confidence: 99%

Surface Functionalization of Polyethersulfone Membrane with Quaternary Ammonium Salts for Contact-Active Antibacterial and Anti-Biofouling Properties

Lin

Zhao

et al. 2016

Materials

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Biofilm is a significant cause for membrane fouling. Antibacterial-coated surfaces can inhibit biofilm formation by killing bacteria. In this study, polyethersulfone (PES) microfiltration membrane was photografted by four antibiotic quaternary ammonium compounds (QACs) separately, which were synthesized from dimethylaminoethyl methacrylate (DMAEMA) by quaternization with butyl bromide (BB), octyl bromide (OB), dodecyl bromide (DB), or hexadecyl bromide (HB). XPS, ATR-FTIR, and SEM were used to confirm the surfaces’ composition and morphology. After modification, the pores on PES-g-DMAEMA-BB and PES-g-DMAEMA-OB were blocked, while PES-g-DMAEMA-DB and PES-g-DMAEMA-HB were retained. We supposed that DMAEMA-BB and DMAEMA-OB aggregated on the membrane surface due to the activities of intermolecular or intramolecular hydrogen bonds. Bacteria testing found the antibacterial activities of the membranes increased with the length of the substituted alkyl chain. Correspondingly, little bacteria were observed on PES-g-DMAEMA-DB and PES-g-DMAEMA-HB by SEM. The antifouling properties were investigated by filtration of a solution of Escherichia coli. Compared with the initial membrane, PES-g-DMAEMA-DB and PES-g-DMAEMA-HB showed excellent anti-biofouling performance with higher relative flux recovery (RFR) of 88.3% and 92.7%, respectively. Thus, surface functionalization of the PES membrane with QACs can prevent bacteria adhesion and improve the anti-biofouling activity by the contact-active antibacterial property.

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Effects of quaternization on the morphological stability and antibacterial activity of electrospun poly(DMAEMA-co-AMA) nanofibers

Cited by 26 publications

References 47 publications

Two Sides of Electrospun Fiber in Promoting and Inhibiting Biomedical Processes

Two Sides of Electrospun Fiber in Promoting and Inhibiting Biomedical Processes

Effect of HA Nanoparticles on Adsorption of Vitamin D3 on Super-Hydrophobic PA6 Nanofibrous Scaffold

Surface Functionalization of Polyethersulfone Membrane with Quaternary Ammonium Salts for Contact-Active Antibacterial and Anti-Biofouling Properties

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