Effects of Quercetin and EGCG on Mitochondrial Biogenesis and Immunity

Nieman, David C.; Henson, Dru A.; Maxwell, Kendra R.; Williams, Ashley S.; McAnulty, Steven R.; Jin, Fuxia; Shanely, R. Andrew; Lines, T.C.

doi:10.1249/mss.0b013e318199491f

Cited by 127 publications

(117 citation statements)

References 37 publications

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“…However, the post-exercise-induced decrease in oxidative burst was unaffected after bolus consumption of the same supplement [29, 30], when hydroethidine was used as probe [30]. Therefore our results confirm that the plasma membrane C-11 BODIPY is a suitable probe in the evaluation of the effects on the oxidative burst of flavonoids, which increase DHR123 accumulation [31].…”

Section: Discussionsupporting

confidence: 65%

“…We have found a nonsignificant decrease of PMA-induced lipoperoxidation after GTE consumption, contrarily with the increase of the oxidative burst of granulocyte, observed in cyclists when quercetin was administered with the tea flavanol epigallocatechin 3-gallate, by using dihydrorhodamine 123 (DHR123) as fluorescence probe [29]. However, the post-exercise-induced decrease in oxidative burst was unaffected after bolus consumption of the same supplement [29, 30], when hydroethidine was used as probe [30].…”

Section: Discussionmentioning

confidence: 99%

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The Peroxidation of Leukocytes Index Ratio Reveals the Prooxidant Effect of Green Tea Extract

Peluso

Manafikhi

Raguzzini

et al. 2016

Oxidative Medicine and Cellular Longevity

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Despite tea increased plasma nonenzymatic antioxidant capacity, the European Food Safety Administration (EFSA) denied claims related to tea and its protection from oxidative damage. Furthermore, the Supplement Information Expert Committee (DSI EC) expressed some doubts on the safety of green tea extract (GTE). We performed a pilot study in order to evaluate the effect of a single dose of two capsules of a GTE supplement (200 mg × 2) on the peroxidation of leukocytes index ratio (PLIR) in relation to uric acid (UA) and ferric reducing antioxidant potential (FRAP), as well as the sample size to reach statistical significance. GTE induced a prooxidant effect on leukocytes, whereas FRAP did not change, in agreement with the EFSA and the DSI EC conclusions. Besides, our results confirm the primary role of UA in the antioxidant defences. The ratio based calculation of the PLIR reduced the sample size to reach statistical significance, compared to the resistance to an exogenous oxidative stress and to the functional capacity of oxidative burst. Therefore, PLIR could be a sensitive marker of redox status.

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Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

The Peroxidation of Leukocytes Index Ratio Reveals the Prooxidant Effect of Green Tea Extract

Peluso

Manafikhi

Raguzzini

et al. 2016

Oxidative Medicine and Cellular Longevity

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“…In another study [61] the effects of quercetin on inflammation and exercise-induced muscle damage in 39 trained cyclists were evaluated. In this study quercetin was provided in association with Vitamin C, niacinamide, and folic acid (Q) or in association with Vitamin C, niacinamide, folic acid, catechin, isoquercetin, and PUFA (Q-EGCG) for 2 weeks before, during, and 1 week after a 3 days period in which the subject cycled for 3 h/die.…”

Section: Flavonoidsmentioning

confidence: 99%

Polyphenols in Exercise Performance and Prevention of Exercise-Induced Muscle Damage

Malaguti

Angeloni

Hrelia

2013

Oxidative Medicine and Cellular Longevity

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Although moderate physical exercise is considered an essential component of a healthy lifestyle that leads the organism to adapt itself to different stresses, exercise, especially when exhaustive, is also known to induce oxidative stress, inflammation, and muscle damage. Many efforts have been carried out to identify dietary strategies or micronutrients able to prevent or at least attenuate the exercise-induced muscle damage and stress. Unfortunately most studies have failed to show protection, and at the present time data supporting the protective effect of micronutrients, as antioxidant vitamins, are weak and trivial. This review focuses on those polyphenols, present in the plant kingdom, that have been recently suggested to exert some positive effects on exercise-induced muscle damage and oxidative stress. In the last decade flavonoids as quercetin, catechins, and other polyphenols as resveratrol have caught the scientists attention. However, at the present time drawing a clear and definitive conclusion seems to be untimely.

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“…Ingestion of a phytochemical-rich fruit juice or grape extracts can prevent post-prandial OSI induced by a high-fat meal challenge in healthy volunteers 10–12 . Similarly, positive health effects of phytochemicals have been demonstrated to attenuate the OSI associated with exercise in athletes 13, 14 .…”

Section: Introductionmentioning

confidence: 97%

Physicochemical properties of dietary phytochemicals can predict their passive absorption in the human small intestine

Selby-Pham

Miller

Howell

et al. 2017

Sci Rep

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A diet high in phytochemical-rich plant foods is associated with reducing the risk of chronic diseases such as cardiovascular and neurodegenerative diseases, obesity, diabetes and cancer. Oxidative stress and inflammation (OSI) is the common component underlying these chronic diseases. Whilst the positive health effects of phytochemicals and their metabolites have been demonstrated to regulate OSI, the timing and absorption for best effect is not well understood. We developed a model to predict the time to achieve maximal plasma concentration (Tmax) of phytochemicals in fruits and vegetables. We used a training dataset containing 67 dietary phytochemicals from 31 clinical studies to develop the model and validated the model using three independent datasets comprising a total of 108 dietary phytochemicals and 98 pharmaceutical compounds. The developed model based on dietary intake forms and the physicochemical properties lipophilicity and molecular mass accurately predicts Tmax of dietary phytochemicals and pharmaceutical compounds over a broad range of chemical classes. This is the first direct model to predict Tmax of dietary phytochemicals in the human body. The model informs the clinical dosing frequency for optimising uptake and sustained presence of dietary phytochemicals in circulation, to maximise their bio-efficacy for positively affect human health and managing OSI in chronic diseases.

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Effects of Quercetin and EGCG on Mitochondrial Biogenesis and Immunity

Abstract: Two-week supplementation with Q-EGCG was effective in augmenting GOBA andin countering inflammation after 3 d of heavy exertion in trained cyclists.

Cited by 127 publications

References 37 publications

The Peroxidation of Leukocytes Index Ratio Reveals the Prooxidant Effect of Green Tea Extract

The Peroxidation of Leukocytes Index Ratio Reveals the Prooxidant Effect of Green Tea Extract

Polyphenols in Exercise Performance and Prevention of Exercise-Induced Muscle Damage

Physicochemical properties of dietary phytochemicals can predict their passive absorption in the human small intestine

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