Effects of quercetin on the sleep–wake cycle in rats: Involvement of gamma-aminobutyric acid receptor type A in regulation of rapid eye movement sleep

Kambe, Daiji; Kotani, Makiko; Yoshimoto, Makoto; Kaku, Shinsuke; Chaki, Shigeyuki; Honda, Kazuo

doi:10.1016/j.brainres.2010.03.033

Cited by 34 publications

(19 citation statements)

References 37 publications

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“…Class II consisted of four groups (G6–G9; ten rats per group) orally administered 1 g/kg body weight/day for 5 days n-ZnO [25] and divided as follows:…”

Section: Methodsmentioning

confidence: 99%

Role of quercetin and arginine in ameliorating nano zinc oxide-induced nephrotoxicity in rats

Faddah

Baky

Al-Rasheed

et al. 2012

BMC Complement Altern Med

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BackgroundNanoparticles are small-scale substances (<100 nm) with unique properties. Therefore, nanoparticles pose complex health risk implications. The objective of this study was to detect whether treatment with quercetin (Qur) and/or arginine (Arg) ameliorated nephrotoxicity induced by two different doses of nano zinc oxide (n-ZnO) particles.MethodZnO nanoparticles were administered orally in two doses (either 600 mg or 1 g/Kg body weight/day for 5 conscutive days) to Wister albino rats. In order to detect the protective effects of the studied antioxidants against n-ZnO induced nepherotoxicity, different biochemical parameters were investigated. Moreover, histopathological examination of kidney tissue was performed.ResultsNano zinc oxide-induced nephrotoxicity was confirmed by the elevation in serum inflammatory markers including: tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6); and C-reactive protein (CRP). Moreover, immunoglobulin (IGg), vascular endothelium growth factor (VEGF), and nitric oxide (NO) were significantly increased in rat serum. Serum urea and creatinine levels were also significantly increased in rats intoxicated with n-ZnO particles compared with the control group. Additionally, a significant decrease in the non-enzymatic antioxidant reduced glutathione (GSH) was shown in kidney tissues and serum glucose levels were increased. These biochemical findings were supported by a histopathological examination of kidney tissues, which showed that in the animals that received a high dose of n-ZnO, numerous kidney glomeruli underwent atrophy and fragmentation. Moreover, the renal tubules showed epithelial desquamation, degeneration and necrosis. Some renal tubules showed casts in their lumina. Severe congestion was also observed in renal interstitium. These effects were dose dependent. Cotreatment of rats with Qur and/or Arg along with n-ZnO significantly improved most of the deviated tested parameters.ConclusionsThe data show that Qur has a beneficial effect against n-ZnO oxidative stress and related vascular complications. Also, its combination with Arg proved to be even more effective in ameliorating nano zinc oxide nephrotoxicity.

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“…Class II consisted of four groups (G6–G9; ten rats per group) orally administered 1 g/kg body weight/day for 5 days n-ZnO [25] and divided as follows:…”

Section: Methodsmentioning

confidence: 99%

Role of quercetin and arginine in ameliorating nano zinc oxide-induced nephrotoxicity in rats

Faddah

Baky

Al-Rasheed

et al. 2012

BMC Complement Altern Med

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“…After one week acclimation, the rats were kept fasting over night before treatment and randomly divided into two classes according to the dose of TiO2-nanoparticle administration to rats. Class I, consists of five groups (each of ten rats): G1, Normal healthy animals; G2-G4 groups of animals administered orally low dose (600 mg/ Kg body weight/day ) n-TiO2 for 5 constitutive days (Wang and Feng, 2008) and divided as follows: G2, nTiO2 intoxicated animals with oral low dose (600 mg/ Kg/day) daily for 5 constitutive days; G3, n-TiO2 intoxicated animals co-administered quercetin (200 mg/Kg) daily (Kambe et al, 2010); G4, n-TiO2-intoxicated animals coadministered idebenone (200 mg/Kg) daily (Kiyota et al, 2003). Class II consists of 4 groups (G5-G7), each of ten rats, administered orally high dose 1 g/Kg body weight/ day n-TiO2 for 5 constitutive days high (4) and divided as follows: G5, n-TiO2 treated animals with an oral high dose(1 g/Kg/day) daily for 5 days; G6, n-TiO2intoxicated animals co-administered quercetin (200 mg/Kg) daily; G7, n-TiO2-intoxicated animals co-administered idebenone (200 mg/Kg) daily.…”

Section: Animals and Treatmentsmentioning

confidence: 99%

Biochemical responses of nanosize titanium dioxide in the heart of rats following administration of idepenone and quercetin L.M. Faddah*, Nayira A. Abdel Baky, Nouf M. Al-Rasheed and Nawal M. Al-Rasheed

Faddah¹

2013

Afr. J. Pharm. Pharmacol.

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Concerns with the environmental and health risk of widely distributed, commonly used nanoparticles are increasing. As titanium dioxide nanoparticles (TiO 2 NPs) are widely used commercially, their potential toxicity on human health has attracted particular attention. In this paper the in vivo acute toxicity of nano-sized TiO 2 particles (80 nm) to adult rats was investigated before and after treatment with either idebenone or quercetin. Rat groups were orally administered at low (600 mg/kg bw) and a high dose (1 g/kg bw) n-TiO 2 , and the effect of these nanoparticles before and after treatment with either antioxidants was evaluated through measurement of serum tumour necrosis factor (TNF)-α, C-reactive protein, vascular endothelial growth factor (VEGF), immunoglobulin G (IgG), interleukin 6 (Il-6), troponin, myoglobin, creatine kinase-MB (CK-MB) and nitrite levels. In addition, Ca and caspase-3 were measured in the hearts of these animals. DNA damage was also detected using Comet assay. The results showed that both doses of n-TiO 2 caused an elevation in all serum and tissue parameters, which increased with increasing dose. Treatment with either idebenone or quercetin significantly reduced these elevated levels, the improvement being more pronounced with the lower dose. In conclusion, this study aims to give some insight on the toxicity and tissue distribution of orally administered TiO 2 nanoparticles through measurement of an extended set of biochemical parameters in serum and heart tissue to gain information on potential pathological changes after administration of NP-TiO 2. In addition, the protective role of idebenone and quercetin, as therapeutic agents to ameliorate these changes were evaluated.

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“…It has been shown that quercetin is able to cross the blood-brain barrier and to induce some effects in the central nervous system including neuroprotective and antioxidant actions (Paulke et al, 2006 ▶ ; Youdim et al, 2004 ▶ ; Ishisaka et al, 2011 ▶ ). Kambe et al (2010) ▶ demonstrated that quercetin increases non-rapid eye movement sleep in dark period in rats. The depressant activity of some terpenoids in the central nervous system has also been reported by Meckes et al (1996) ▶ .…”

Section: Discussionmentioning

confidence: 99%

Hydroalcoholic Extract of Cuscuta Epithymum Enhances Pentobarbitalinduced Sleep: Possible Involvement of GABAergic System

Forouzanfar

Vahedi

Aghaei

et al. 2020

CDDT

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Objective:Insomnia is accompanied by several health complications and the currently used soporific drugs can induce several side effects such as psychomotor impairment, amnesia, and tolerance. The present study was planned to investigate the sleep prolonging effect of Pinus eldarica.Materials and Methods:Hydroalcoholic extract (HAE) of P. eldarica, its water fraction (WF), ethyl acetate fraction (EAF) and n-butanol fraction (NBF) were injected (intraperitoneally) to mice 30 min before administration of pentobarbital. Then, the latent period and continuous sleeping time were recorded. Also, LD50 of P. eldarica extract was determined and the possible neurotoxicity of the extract was tested on neural PC12 cells.Results:The HAE and NBF decreased the latency of sleep (p<0.05) and significantly increased duration of sleep (p<0.05) induced by pentobarbital. These effects of P. eldarica were reversed by flumazenil. The LD50 value for HAE was found to be 4.8 g/Kg. HAE and its fractions did not show neurotoxic effects in cultured PC12-cell line. Conclusion:The present data indicate that P. eldarica potentiated pentobarbital hypnosis without major toxic effect. Most probably, the main components responsible for this effect are non-polar agents which are found in NBF of this plant.

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Effects of quercetin on the sleep–wake cycle in rats: Involvement of gamma-aminobutyric acid receptor type A in regulation of rapid eye movement sleep

Cited by 34 publications

References 37 publications

Role of quercetin and arginine in ameliorating nano zinc oxide-induced nephrotoxicity in rats

Role of quercetin and arginine in ameliorating nano zinc oxide-induced nephrotoxicity in rats

Biochemical responses of nanosize titanium dioxide in the heart of rats following administration of idepenone and quercetin L.M. Faddah*, Nayira A. Abdel Baky, Nouf M. Al-Rasheed and Nawal M. Al-Rasheed

Hydroalcoholic Extract of Cuscuta Epithymum Enhances Pentobarbitalinduced Sleep: Possible Involvement of GABAergic System

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