2014
DOI: 10.1111/evj.12206
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Effects of quinapril on angiotensin converting enzyme and plasma renin activity as well as pharmacokinetic parameters of quinapril and its active metabolite, quinaprilat, after intravenous and oral administration to mature horses

Abstract: These results suggest that, despite low plasma concentrations, quinapril has sufficient oral absorption to produce inhibition of ACE in healthy horses. Controlled studies in clinically affected horses are indicated. Quinapril provides a potential treatment alternative for horses with cardiovascular and renal disease.

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Cited by 10 publications
(9 citation statements)
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“…Angiotensin‐converting enzyme inhibitors have been recommended widely for the treatment of severe myxomatous degenerative valvular diseases and congestive heart failure (CHF) in horses, despite the paucity of available data regarding their efficacy. Enalapril is not detectable in plasma after oral administration to horses and the oral bioavailability of quinapril in horses is <5% .…”
Section: Introductionmentioning
confidence: 99%
“…Angiotensin‐converting enzyme inhibitors have been recommended widely for the treatment of severe myxomatous degenerative valvular diseases and congestive heart failure (CHF) in horses, despite the paucity of available data regarding their efficacy. Enalapril is not detectable in plasma after oral administration to horses and the oral bioavailability of quinapril in horses is <5% .…”
Section: Introductionmentioning
confidence: 99%
“…M A N U S C R I P T 4 quinapril and ramipril, respectively (Gardner et al, 2004;Davis et al, 2014;Gómez-Díez et al, 2014;Serrano-Rodríguez et al, 2016). To the authors' knowledge, there are three papers regarding benazepril, another ACEI.…”
Section: A C C E P T E Dmentioning
confidence: 99%
“…A C C E P T E D M A N U S C R I P T 9 the necessary amount for IV formulation was not available. Administration of IV benazepril, however, provides important information about the biotransformation to benazeprilat, as described for other ACEIs in horses (Davis et al, 2014;Serrano-Rodríguez et al, 2016).…”
Section: Accepted Manuscriptmentioning
confidence: 99%
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“…Plasma renin activity was determined by the rate of generation of angiotensin I using a radioenzymatic assay (GammaCoat Plasma Renin Activity Radioimmunoassay) e as previously described in horses [16,17]. Serum ACE activity was measured using a kinetic spectrophotometric method, as previously described [13].…”
Section: Blood Collection and Hormone Peptide And Ace Activity Measumentioning
confidence: 99%