Attenuation of the blood pressure response to exogenous angiotensin I after oral administration of benazepril to healthy adult horses

Abstract

Attenuation of the rise in SBP in response to ANG-I after administration of benazepril is modest in horses despite adequate serum ACE inhibition. A dose of 1 mg/kg bwt would be recommended for future investigations of benazepril for the management of cardiovascular diseases in horses.

Preliminary investigation of orally administered benazepril in horses with left‐sided valvular regurgitation

“…The level of serum ACE inhibition in horses with valvular regurgitation obtained in the present study is similar to that previously documented in healthy horses receiving the same dose of benazepril [15]. The mild but statistically significant decrease in ACE inhibition from day 7 to day 28 in the benazepril group was unexpected and suggests the possibility of resistance to ACE blockade over time.…”

“…The dose and dosing interval were based on the results of a prior study [15]. Horses (n = 11) were stratified based on primary haemodynamic abnormality (MR or AR) and horses in each stratum were randomised to receive benazepril or a placebo with the aid of a computer software (MedCalc Statistical Software) a .…”

“…Benazepril Hydrochloride c or placebo tablets were administered orally by owners or farm personnel at a dosage of 1 mg/kg q 12 h for 28 days. The dose and dosing interval were based on the results of a prior study [15]. Compliance by horse owners was monitored by providing a calendar with two check boxes per day.…”

“…Similarly, oral benazepril at the same dose was more effective at attenuating exercise-induced hypertension than enalapril, quinapril or ramipril [14]. More recently, oral benazepril at a dose of 1 mg/kg was superior to a dose of 0.5 mg/kg at attenuating the rise in blood pressure after administration of exogenous angiotensin I, whereas administration of higher dosages did not provide additional benefit [15].…”

Irregular hearts and performance horses

“…Afonso et al, 26,27 and Broux et al, 28 address some related questions in their hypothesis‐driven investigations of benazepril and sotalol, while Mitchell, 11 in a clinical commentary on the diagnosis and treatment of ventricular tachycardia, discusses the pros and cons of several medications. Benazepril is an ACE inhibitor with potential to reduce afterload on the left ventricle.…”