Effects of rebamipide on nephrotoxicity associated with selected NSAIDs in rats

Wood, Robert C.; Wyatt, Jarrett E.; Bullins, Kenny W.; Hanley, Angela; Hanley, Gregory P.; Denham, James W.; Panus, Peter C.; Harirforoosh, Sam

doi:10.1016/j.ejphar.2013.10.035

Cited by 16 publications

(9 citation statements)

References 40 publications

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“…Rebamipide urine analysis was carried out using samples obtained from a previous study [5]. In the study, male Sprague-Dawley rats were dosed with rebamipide (30 mg/kg) twice daily for two days via gastric intubation.…”

Section: Methods Detailsmentioning

confidence: 99%

A simple high performance liquid chromatography method for determination of rebamipide in rat urine

Cooper

Harirforoosh

2014

MethodsX

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Section: Methods Detailsmentioning

confidence: 99%

A simple high performance liquid chromatography method for determination of rebamipide in rat urine

Cooper

Harirforoosh

2014

MethodsX

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“…Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed for the treatment of acute and chronic inflammation, pain, and fever [6]. However, long-term clinical usage of NSAIDs is associated with significant side effects such as gastro-intestinal lesions, bleeding, and nephrotoxicity [7]; therefore, discovery of new safer anti-inflammatory agent presents a challenging goal.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and investigation of the anti-inflammatory effect of 2,3-disubstituted quinazoline-4(1H)-one

Ghodge

Kshirsagar

Navghare

2020

Beni-Suef Univ J Basic Appl Sci

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Background: Quinazolin-4(1H)-one nucleus has attracted the attention of medicinal chemists due to their clinical uses. Modification of quinazolinone ring for the development of pharmaceutical and clinical compound for its antiinflammatory potential. Results: In vitro anti-inflammatory activity of the synthesized compounds was performed by using egg albumin protein denaturation assay, while in vivo anti-inflammatory activity was performed by using carrageenan-induced rat paw edema and cotton pellet-induced granuloma pouch model. In the present study, we synthesized a new series of 2,3-disubstituted quinazolin-4(1H)-one derivatives and evaluated their in vivo, in vitro anti-inflammatory effect. Their chemical structures are confirmed by FTIR, 1 HNMR, and mass spectrum. Among all the synthesized compounds, G1 and G3 exhibit the significant anti-inflammatory activity by inhibiting release of inflammatory mediators like prostaglandin, histamine, and serotonin. in both in vivo and in vitro models as compared to compound G2. Conclusion: These synthesized compounds showed anti-inflammatory activity by inhibiting prostaglandins and COX enzymes. So, all test compounds may be used for both inflammation as well as inflammation-induced cancer therapy. Future various screening method related with inflammation and inflammation-induced cancer needs to be evaluated pre-clinically and clinically.

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“…Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed to lessen the pain and inflammation associated with arthritic diseases 1 , 2 , 3 , 4 . NSAIDs function through the inhibition of cyclooxygenase (primarily COX-1 and COX-2) reducing the production of prostaglandin (PG), a mediator of both pain and inflammation 3 , 5 , 6 . COX-1 is known to be primarily involved in homeostatic physiological processes and constitutively produced in numerous tissues; while the COX-2 isoform is inducible and found principally in association with inflammation 7 , 8 , 9 , 10 .…”

Section: Introductionmentioning

confidence: 99%

Histopathology and oxidative stress analysis of concomitant misoprostol and celecoxib administration

2015

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Nonsteroidal anti-inflammatory drugs (NSAIDs), non-selective or selective inhibitors of cyclooxygenase (COX-1 and -2), reduce pain and inflammation associated with arthritic diseases. Celecoxib, a COX-2-selective inhibitor providing decreased gastric injury relative to non-selective NSAIDs, is commonly prescribed. Misoprostol, a prostaglandin analog, supplements NSAID-inhibited prostaglandin levels. As concomitant celecoxib and misoprostol administration has been shown to intensify renal adverse effects, this article examined the influence of concomitant administration on hepatic histopathology, oxidative stress, and celecoxib concentration. On days 1 and 2, rat groups (n = 6) were gavaged twice daily (two groups with vehicle and two groups with 100 μg/kg misoprostol). From day 3 to day 9, one celecoxib dose (40 mg/kg) replaced a vehicle dose of one group and one group received celecoxib in addition to misoprostol. Livers were harvested on day 10. No hepatic abnormalities were observed denoting a lack of influence by either drug. Also no change in mean biomarker levels was detected. The changes in hepatic celecoxib concentration in the misoprostol-receiving group compared to control were not significant. Thus misoprostol does not influence hepatic celecoxib effects in terms of histopathology, oxidative stress, or celecoxib concentration level at the dosage and duration examined.

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Effects of rebamipide on nephrotoxicity associated with selected NSAIDs in rats

Cited by 16 publications

References 40 publications

A simple high performance liquid chromatography method for determination of rebamipide in rat urine

A simple high performance liquid chromatography method for determination of rebamipide in rat urine

Synthesis, characterization, and investigation of the anti-inflammatory effect of 2,3-disubstituted quinazoline-4(1H)-one

Histopathology and oxidative stress analysis of concomitant misoprostol and celecoxib administration

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