1990
DOI: 10.1111/j.1528-1157.1990.tb06110.x
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Effects of Removal of Phenytoin, Carbamazepine, and Valproate on Cognitive Function

Abstract: Changes in cognitive function were noted in a double-blind, prospective, placebo-controlled study of discontinuation of phenytoin (PHT), carbamazepine (CBZ), and valproate (VPA) in 58 patients with active epilepsy, receiving multiple antiepileptic drugs (AEDs). A control group of 25 patients continued with existing therapy. A simple test battery, which would be directly applicable to a clinical setting, with measures of mental speed, attention, performance of a learned skill, short-term memory, concentration, … Show more

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Cited by 77 publications
(45 citation statements)
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“…A double-blind trial reported deterioration in measures of information processing speed and attention [Wesnes et al 2009]. Other studies report poorer verbal fluency in adults with partial seizures than in control subjects [Aikiä et al 2006], detrimental effects on memory [Shehata et al 2009;Forsythe et al 1991], worse arithmetic performance [Kang et al 2007] and faster motor skills after discontinuation [Duncan et al 1990]. Impaired movement time, reaction time, finger tapping rate and number cancellation were seen in one study, but these effects remitted by 1 month after treatment commencement [Larkin et al 1992].…”
Section: Phenytoinmentioning
confidence: 99%
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“…A double-blind trial reported deterioration in measures of information processing speed and attention [Wesnes et al 2009]. Other studies report poorer verbal fluency in adults with partial seizures than in control subjects [Aikiä et al 2006], detrimental effects on memory [Shehata et al 2009;Forsythe et al 1991], worse arithmetic performance [Kang et al 2007] and faster motor skills after discontinuation [Duncan et al 1990]. Impaired movement time, reaction time, finger tapping rate and number cancellation were seen in one study, but these effects remitted by 1 month after treatment commencement [Larkin et al 1992].…”
Section: Phenytoinmentioning
confidence: 99%
“…Another study showed no relationship between plasma concentration and cognitive performance in children [Brouwer et al 1992]. One double-blind, placebo-controlled study reported more convincing evidence of improved motor skills after discontinuation [Duncan et al 1990]. Fortunately, the CAEs associated with valproate are likely to be reversible [Galassi et al 1990].…”
Section: Sodium Valproate and Ethosuximidementioning
confidence: 99%
“…25 Other studies found no difference in memory performance between children administered carbamazepine versus phenytoin. 26,27 Differences in findings may relate to many differences in study designs, including memory measures used and differences in participant characteristics. With respect to comparative effects on other neurocognitive functions, perceptual-motor coordination appears to be less affected by carbamazepine than phenytoin in children with newly diagnosed seizure disorders.…”
Section: Carbamazepinementioning
confidence: 99%
“…25 Carbamazepine treatment is not thought to be associated with greater difficulty with attention, Stroop performance, visual scanning, or speed of information processing than either phenytoin or valproate treatment. 26,27 Studies examining the impact of carbamazepine versus valproate on cognitive functioning generally conclude that if there is an impact of either medication, it is minimal. The results of only one study indicated that memory was adversely affected in children prescribed carbamazepine relative to children prescribed valproate.…”
Section: Carbamazepinementioning
confidence: 99%
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